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- W2018898660 abstract "Abstract Rationale Excessive crying and distress (colic) affects 10 to 20% of infants. Breast milk contains trace amounts of maternally ingested dietary antigens. We hypothesized hypersensitivity to trace amounts of proteins in breast milk elicits infantile colic. Methods Breast-fed infants, diet which excluded milk, egg, wheat, peanut, tree nuts and fish or a control diet which contained these foods. Based on our previous studies 45 patients in each low-allergen and control diet group would detect an 80% probability of a significant effect at the 0.05 level. The response to diet intervention was assessed using previously validated infant distress score charts. The primary criteria of a response was a fall in distress scores ≥25% after 7 days. Results Of 107 infants who entered the study 90 completed the program; 47 received the and 43 control diet. Distress was reduced by ≥25% in 74% of the group vs 34% of the control group (p group had 128 minutes less distress than the control group (p=0.01). Including non-completers (drop-out's) as either responders or non-responders did not affect the conclusions. Conclusions Colic in breast fed infants, less than 6 weeks of age is associated with intolerance to dietary proteins excreted in breast milk and responds to a maternal diet." @default.
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- W2018898660 date "2004-02-01" @default.
- W2018898660 modified "2023-09-27" @default.
- W2018898660 title "Colic in breast fed infants is due to hypersensitivity to dietary proteins excreted in breast milk*1" @default.
- W2018898660 doi "https://doi.org/10.1016/j.jaci.2004.01.724" @default.
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