Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018902003> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2018902003 endingPage "612" @default.
- W2018902003 startingPage "607" @default.
- W2018902003 abstract "Thirty-one patients with IgG antibodies to cardiolipin (ACLA) were studied to determine their in vivo formation of the platelet aggregating and vasoconstricting substance thromboxane A2 (TxA2) and the platelet inhibiting and vasodilating substance prostacyclin (PGI2). This was done by measurements in urine of their enzymatically formed metabolites 2,3-dinor-TxB2 and 2,3-dinor-6-keto-PGF1 alpha, respectively, using gas chromatography-mass spectrometry. It is demonstrated that patients with IgG ACLA have a highly significant increase in the biosynthesis of TxA2 compared with age-matched healthy controls (807 +/- 163 [SEM] vs. 230 +/- 15 pg mg-1 creatinine, P = 0.0000005). A significant increment of the formation of PGI2 was also found (189 +/- 23 (SEM) vs. 125 +/- 11 pg mg-1 creatinine, P = 0.03), although this was much less pronounced than that for TxA2. We conclude that the highly increased formation of TxA2, reflecting platelet activation, in patients with IgG ACLA is of pathophysiologic relevance for their tendency to arterial and venous thrombosis and hence that they should be considered for prophylactic treatment with inhibitors of TxA2 formation, like aspirin." @default.
- W2018902003 created "2016-06-24" @default.
- W2018902003 creator A5062754976 @default.
- W2018902003 creator A5079075269 @default.
- W2018902003 creator A5081165719 @default.
- W2018902003 creator A5038236628 @default.
- W2018902003 date "2008-06-28" @default.
- W2018902003 modified "2023-09-26" @default.
- W2018902003 title "Increased thromboxane formation in patients with antiphospholipid syndrome" @default.
- W2018902003 cites W1973343984 @default.
- W2018902003 cites W1974759983 @default.
- W2018902003 cites W1990157378 @default.
- W2018902003 cites W1992453746 @default.
- W2018902003 cites W2000055469 @default.
- W2018902003 cites W2002936140 @default.
- W2018902003 cites W2003584270 @default.
- W2018902003 cites W2007361354 @default.
- W2018902003 cites W2030087792 @default.
- W2018902003 cites W2034536826 @default.
- W2018902003 cites W2046771483 @default.
- W2018902003 cites W2065710903 @default.
- W2018902003 cites W2069885733 @default.
- W2018902003 cites W2070695546 @default.
- W2018902003 cites W2138858884 @default.
- W2018902003 cites W2146203649 @default.
- W2018902003 cites W2149567495 @default.
- W2018902003 cites W2153006626 @default.
- W2018902003 cites W2397976183 @default.
- W2018902003 cites W2443941861 @default.
- W2018902003 cites W4231797090 @default.
- W2018902003 cites W4245466284 @default.
- W2018902003 doi "https://doi.org/10.1111/j.1365-2362.1990.tb01908.x" @default.
- W2018902003 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2127750" @default.
- W2018902003 hasPublicationYear "2008" @default.
- W2018902003 type Work @default.
- W2018902003 sameAs 2018902003 @default.
- W2018902003 citedByCount "37" @default.
- W2018902003 countsByYear W20189020032013 @default.
- W2018902003 countsByYear W20189020032015 @default.
- W2018902003 countsByYear W20189020032019 @default.
- W2018902003 countsByYear W20189020032021 @default.
- W2018902003 crossrefType "journal-article" @default.
- W2018902003 hasAuthorship W2018902003A5038236628 @default.
- W2018902003 hasAuthorship W2018902003A5062754976 @default.
- W2018902003 hasAuthorship W2018902003A5079075269 @default.
- W2018902003 hasAuthorship W2018902003A5081165719 @default.
- W2018902003 hasConcept C10162356 @default.
- W2018902003 hasConcept C126322002 @default.
- W2018902003 hasConcept C134018914 @default.
- W2018902003 hasConcept C185592680 @default.
- W2018902003 hasConcept C2776785769 @default.
- W2018902003 hasConcept C2776874634 @default.
- W2018902003 hasConcept C2777628954 @default.
- W2018902003 hasConcept C2780026642 @default.
- W2018902003 hasConcept C2780306776 @default.
- W2018902003 hasConcept C2780868729 @default.
- W2018902003 hasConcept C2781024287 @default.
- W2018902003 hasConcept C2781080829 @default.
- W2018902003 hasConcept C2781128415 @default.
- W2018902003 hasConcept C3018697912 @default.
- W2018902003 hasConcept C71924100 @default.
- W2018902003 hasConcept C89560881 @default.
- W2018902003 hasConceptScore W2018902003C10162356 @default.
- W2018902003 hasConceptScore W2018902003C126322002 @default.
- W2018902003 hasConceptScore W2018902003C134018914 @default.
- W2018902003 hasConceptScore W2018902003C185592680 @default.
- W2018902003 hasConceptScore W2018902003C2776785769 @default.
- W2018902003 hasConceptScore W2018902003C2776874634 @default.
- W2018902003 hasConceptScore W2018902003C2777628954 @default.
- W2018902003 hasConceptScore W2018902003C2780026642 @default.
- W2018902003 hasConceptScore W2018902003C2780306776 @default.
- W2018902003 hasConceptScore W2018902003C2780868729 @default.
- W2018902003 hasConceptScore W2018902003C2781024287 @default.
- W2018902003 hasConceptScore W2018902003C2781080829 @default.
- W2018902003 hasConceptScore W2018902003C2781128415 @default.
- W2018902003 hasConceptScore W2018902003C3018697912 @default.
- W2018902003 hasConceptScore W2018902003C71924100 @default.
- W2018902003 hasConceptScore W2018902003C89560881 @default.
- W2018902003 hasIssue "6" @default.
- W2018902003 hasLocation W20189020031 @default.
- W2018902003 hasLocation W20189020032 @default.
- W2018902003 hasOpenAccess W2018902003 @default.
- W2018902003 hasPrimaryLocation W20189020031 @default.
- W2018902003 hasRelatedWork W1574451752 @default.
- W2018902003 hasRelatedWork W2090866746 @default.
- W2018902003 hasRelatedWork W2091233247 @default.
- W2018902003 hasRelatedWork W2120301728 @default.
- W2018902003 hasRelatedWork W2317069681 @default.
- W2018902003 hasRelatedWork W2397984585 @default.
- W2018902003 hasRelatedWork W2405084813 @default.
- W2018902003 hasRelatedWork W2412382344 @default.
- W2018902003 hasRelatedWork W2417996629 @default.
- W2018902003 hasRelatedWork W3140773452 @default.
- W2018902003 hasVolume "20" @default.
- W2018902003 isParatext "false" @default.
- W2018902003 isRetracted "false" @default.
- W2018902003 magId "2018902003" @default.
- W2018902003 workType "article" @default.