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• W2018906759 abstract "Model Maillard reaction (MR) products (MRPs) employing lysine with an aldohexose (e.g., glucose), ketohexose (e.g., fructose), and aldopentose (e.g., ribose) sugars were generated (e.g., pH 9.0; over 2h heating at 120 degrees ) and fractionated with ethanol into low (LMW) and high (HMW) molecular weight fractions. Characteristically different temporal patterns of fluorescence and ultraviolet/visible absorption spectra were obtained from the three distinct sugar-lysine MRPs, and corresponded to different yields of total and dialyzable carbon, indicating that relative reaction rates and degree of polymerization favored the Rib-Lys MRP, compared to Glu-Lys and Fru-Lys MRPs, respectively (p<0.05). Further characterization of antioxidant activity of the sugar specific-lysine MRPs in chemical (e.g., hydrophobic (1,1,-diphenyl-2-picryl-hydrazyl radical (DPPH) and hydrophilic (Fenton reaction-induced hydroxyl radical) in vitro scavenging assays showed that Rib-Lys HMW MRPs had the highest (p<0.05) affinity to scavenge free radicals. All sugar-Lys MRPs, however, displayed similar protection of cultured Caco-2 cells from exposure to H(2)O(2)-, 2,2'-azobis-(2-amidinopropane) dihydrochloride (AAPH)-, ferrous (Fe(2+))-, and cupric (Cu(2+))-induced cytotoxicity, evaluated both from redox (e.g., MTT response) and cell membrane integrity (e.g., LDH secretion). HMW-MRPs exhibited stronger (p<0.05) antioxidant activity to scavenge hydroxyl and DPPH radicals, and a greater (p<0.05) protective effect against both Fe(2+)- and Cu(2+)-induced cytotoxicity in Caco-2 cells than corresponding LMW-MRPs. We conclude that HMW MRPs possess affective antioxidant protection against oxidizable substrates; however, the degree of polymerization of this product, characteristic to the source of monosaccharide used in the reaction, is not a distinguishable factor for this bioactivity." @default.
• W2018906759 created "2016-06-24" @default.
• W2018906759 creator A5001687616 @default.
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• W2018906759 date "2004-09-01" @default.
• W2018906759 modified "2023-10-01" @default.
• W2018906759 title "Antioxidant activity of sugar–lysine Maillard reaction products in cell free and cell culture systems" @default.
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• W2018906759 doi "https://doi.org/10.1016/j.abb.2004.06.019" @default.
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