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• W2018927139 startingPage "646" @default.
• W2018927139 abstract "Lipid sensing and insulin signaling in the brain independently triggers a negative feedback system to lower glucose production and food intake. Here, we discuss the underlying molecular and neuronal mechanisms of lipid sensing and insulin signaling in the hypothalamus and how these mechanisms are affected in response to high-fat feeding. We propose that high-fat feeding concurrently disrupts hypothalamic insulin-signaling and lipid-sensing mechanisms and that experiments aimed to restore both insulin action and lipid sensing in the brain could effectively lower glucose production and food intake to restore metabolic homeostasis in type 2 diabetes and obesity. Lipid sensing and insulin signaling in the brain independently triggers a negative feedback system to lower glucose production and food intake. Here, we discuss the underlying molecular and neuronal mechanisms of lipid sensing and insulin signaling in the hypothalamus and how these mechanisms are affected in response to high-fat feeding. We propose that high-fat feeding concurrently disrupts hypothalamic insulin-signaling and lipid-sensing mechanisms and that experiments aimed to restore both insulin action and lipid sensing in the brain could effectively lower glucose production and food intake to restore metabolic homeostasis in type 2 diabetes and obesity." @default.
• W2018927139 created "2016-06-24" @default.
• W2018927139 creator A5050303972 @default.
• W2018927139 creator A5087801204 @default.
• W2018927139 date "2012-05-01" @default.
• W2018927139 modified "2023-10-18" @default.
• W2018927139 title "Lipid Sensing and Insulin Resistance in the Brain" @default.
• W2018927139 cites W1548938601 @default.
• W2018927139 cites W1577348758 @default.
• W2018927139 cites W1772857860 @default.
• W2018927139 cites W1866620858 @default.
• W2018927139 cites W1963957834 @default.
• W2018927139 cites W1964532167 @default.
• W2018927139 cites W1964562779 @default.
• W2018927139 cites W1965019847 @default.
• W2018927139 cites W1971604081 @default.
• W2018927139 cites W1973181474 @default.
• W2018927139 cites W1975369894 @default.
• W2018927139 cites W1975862819 @default.
• W2018927139 cites W1977275538 @default.
• W2018927139 cites W1978248654 @default.
• W2018927139 cites W1985224848 @default.
• W2018927139 cites W1986673931 @default.
• W2018927139 cites W1989528677 @default.
• W2018927139 cites W1993353490 @default.
• W2018927139 cites W1993642953 @default.
• W2018927139 cites W1997192581 @default.
• W2018927139 cites W2012295774 @default.
• W2018927139 cites W2016526819 @default.
• W2018927139 cites W2016850962 @default.
• W2018927139 cites W2017712441 @default.
• W2018927139 cites W2021699445 @default.
• W2018927139 cites W2021729437 @default.
• W2018927139 cites W2022362070 @default.
• W2018927139 cites W2024138018 @default.
• W2018927139 cites W2024376388 @default.
• W2018927139 cites W2027065972 @default.
• W2018927139 cites W2028035581 @default.
• W2018927139 cites W2029875505 @default.
• W2018927139 cites W2030111077 @default.
• W2018927139 cites W2037226098 @default.
• W2018927139 cites W2040750115 @default.
• W2018927139 cites W2040917885 @default.
• W2018927139 cites W2040973524 @default.
• W2018927139 cites W2042144976 @default.
• W2018927139 cites W2043394717 @default.
• W2018927139 cites W2044734540 @default.
• W2018927139 cites W2048715566 @default.
• W2018927139 cites W2050548172 @default.
• W2018927139 cites W2051037127 @default.
• W2018927139 cites W2052985185 @default.
• W2018927139 cites W2054716401 @default.
• W2018927139 cites W2055382292 @default.
• W2018927139 cites W2056448740 @default.
• W2018927139 cites W2057182111 @default.
• W2018927139 cites W2057386105 @default.
• W2018927139 cites W2061980259 @default.
• W2018927139 cites W2064182395 @default.
• W2018927139 cites W2065676791 @default.
• W2018927139 cites W2067242542 @default.
• W2018927139 cites W2067378751 @default.
• W2018927139 cites W2067875627 @default.
• W2018927139 cites W2070072467 @default.
• W2018927139 cites W2072556905 @default.
• W2018927139 cites W2073656642 @default.
• W2018927139 cites W2075792687 @default.
• W2018927139 cites W2076637814 @default.
• W2018927139 cites W2077033935 @default.
• W2018927139 cites W2078940647 @default.
• W2018927139 cites W2079395662 @default.
• W2018927139 cites W2081561618 @default.
• W2018927139 cites W2082113374 @default.
• W2018927139 cites W2085184474 @default.
• W2018927139 cites W2088777766 @default.
• W2018927139 cites W2089541211 @default.
• W2018927139 cites W2090556647 @default.
• W2018927139 cites W2090642832 @default.
• W2018927139 cites W2090699565 @default.
• W2018927139 cites W2094419252 @default.
• W2018927139 cites W2095260583 @default.
• W2018927139 cites W2097535416 @default.
• W2018927139 cites W2098465489 @default.
• W2018927139 cites W2099584401 @default.
• W2018927139 cites W2101782891 @default.
• W2018927139 cites W2106270379 @default.
• W2018927139 cites W2106866775 @default.
• W2018927139 cites W2110058008 @default.
• W2018927139 cites W2111160635 @default.
• W2018927139 cites W2111509554 @default.
• W2018927139 cites W2115138453 @default.
• W2018927139 cites W2116141391 @default.
• W2018927139 cites W2120276257 @default.
• W2018927139 cites W2121614675 @default.
• W2018927139 cites W2123226457 @default.
• W2018927139 cites W2126317966 @default.
• W2018927139 cites W2126909426 @default.
• W2018927139 cites W2128679037 @default.
• W2018927139 cites W2133966719 @default.

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