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- W2018934996 abstract "Cocrystals have been increasingly recognized as an attractive alternative for solid forms of drug products. In this work, nicotinamide (NCT) was employed as a cocrystal former with the active pharmaceutical ingredient theophylline (TP). The theophylline−nicotinamide cocrystal (hereafter TP-NCT cocrystal) was prepared by solid-state grinding and slow evaporation from ethanol, and was characterized by differential scanning calorimetry (DSC), thermogravimetric analysis (TGA), hot-stage optical microscopy (HSM), Raman spectroscopy, and powder X-ray diffraction (PXRD) techniques. Pharmaceutically relevant properties such as powder dissolution rate, solubility and dynamic vapour sorption (DVS) of the TP-NCT cocrystal were evaluated. The results show that, the TP-NCT cocrystal, obtained in a 1:1 molar ratio of theophylline and nicotinamide, possesses unique thermal, spectroscopic, and X-ray diffraction properties. In addition, the solubility and hygroscopicity of the TP-NCT cocrystal were considerably higher than those of anhydrous theophylline." @default.
- W2018934996 created "2016-06-24" @default.
- W2018934996 creator A5014090175 @default.
- W2018934996 creator A5028846514 @default.
- W2018934996 date "2009-05-28" @default.
- W2018934996 modified "2023-09-23" @default.
- W2018934996 title "Preparation and Characterization of Theophylline−Nicotinamide Cocrystal" @default.
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- W2018934996 doi "https://doi.org/10.1021/op900047r" @default.
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