Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018935611> ?p ?o ?g. }
Showing items 1 to 98 of
98
with 100 items per page.
- W2018935611 endingPage "362" @default.
- W2018935611 startingPage "357" @default.
- W2018935611 abstract "The in vitro activity of A21978C1, a novel cyclic polypeptide antibiotic, was compared with those of vancomycin, teichomycin, and several beta-lactam antibiotics against gram-positive bacteria. The new drug was at least as active as vancomycin against all species of streptococci and staphylococci tested, including methicillin-resistant Staphylococcus aureus and penicillin-resistant pneumococci. Activity of the drug was found to be strongly correlated with the calcium concentration in test media. Against enterococci, A21978C1 was bactericidal at concentrations near the MIC (MIC for 100% of the strains, 2 micrograms/ml), but combining that drug with gentamicin resulted in bactericidal synergism by time-kill methods. Studies were undertaken to examine the mechanism of action of the drug. A21978C1 did not interact with penicillin-binding proteins of bacterial cell membranes. No direct effect of the drug on the synthesis of DNA, RNA, or protein by a susceptible strain of Streptococcus faecalis could be demonstrated. However, A21978C1 inhibited peptidoglycan synthesis in early-log-phase cultures of both Streptococcus faecalis and Staphylococcus aureus." @default.
- W2018935611 created "2016-06-24" @default.
- W2018935611 creator A5002504257 @default.
- W2018935611 creator A5012266980 @default.
- W2018935611 creator A5017444673 @default.
- W2018935611 creator A5041580031 @default.
- W2018935611 date "1985-03-01" @default.
- W2018935611 modified "2023-10-14" @default.
- W2018935611 title "In vitro activity and mechanism of action of A21978C1, a novel cyclic lipopeptide antibiotic" @default.
- W2018935611 cites W1501707669 @default.
- W2018935611 cites W1775749144 @default.
- W2018935611 cites W1855093475 @default.
- W2018935611 cites W1970387257 @default.
- W2018935611 cites W1972922048 @default.
- W2018935611 cites W1984726206 @default.
- W2018935611 cites W2005683797 @default.
- W2018935611 cites W2030371182 @default.
- W2018935611 cites W2032783304 @default.
- W2018935611 cites W2039063878 @default.
- W2018935611 cites W2042976182 @default.
- W2018935611 cites W2132050847 @default.
- W2018935611 cites W2211457795 @default.
- W2018935611 doi "https://doi.org/10.1128/aac.27.3.357" @default.
- W2018935611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/176277" @default.
- W2018935611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/3994349" @default.
- W2018935611 hasPublicationYear "1985" @default.
- W2018935611 type Work @default.
- W2018935611 sameAs 2018935611 @default.
- W2018935611 citedByCount "94" @default.
- W2018935611 countsByYear W20189356112012 @default.
- W2018935611 countsByYear W20189356112013 @default.
- W2018935611 countsByYear W20189356112014 @default.
- W2018935611 countsByYear W20189356112015 @default.
- W2018935611 countsByYear W20189356112016 @default.
- W2018935611 countsByYear W20189356112017 @default.
- W2018935611 countsByYear W20189356112018 @default.
- W2018935611 countsByYear W20189356112019 @default.
- W2018935611 crossrefType "journal-article" @default.
- W2018935611 hasAuthorship W2018935611A5002504257 @default.
- W2018935611 hasAuthorship W2018935611A5012266980 @default.
- W2018935611 hasAuthorship W2018935611A5017444673 @default.
- W2018935611 hasAuthorship W2018935611A5041580031 @default.
- W2018935611 hasBestOaLocation W20189356111 @default.
- W2018935611 hasConcept C174802600 @default.
- W2018935611 hasConcept C202751555 @default.
- W2018935611 hasConcept C2775832221 @default.
- W2018935611 hasConcept C2776634448 @default.
- W2018935611 hasConcept C2777425210 @default.
- W2018935611 hasConcept C2778276568 @default.
- W2018935611 hasConcept C2778980435 @default.
- W2018935611 hasConcept C2779306812 @default.
- W2018935611 hasConcept C2779489039 @default.
- W2018935611 hasConcept C2779895986 @default.
- W2018935611 hasConcept C501593827 @default.
- W2018935611 hasConcept C523546767 @default.
- W2018935611 hasConcept C54355233 @default.
- W2018935611 hasConcept C55493867 @default.
- W2018935611 hasConcept C86803240 @default.
- W2018935611 hasConcept C89423630 @default.
- W2018935611 hasConceptScore W2018935611C174802600 @default.
- W2018935611 hasConceptScore W2018935611C202751555 @default.
- W2018935611 hasConceptScore W2018935611C2775832221 @default.
- W2018935611 hasConceptScore W2018935611C2776634448 @default.
- W2018935611 hasConceptScore W2018935611C2777425210 @default.
- W2018935611 hasConceptScore W2018935611C2778276568 @default.
- W2018935611 hasConceptScore W2018935611C2778980435 @default.
- W2018935611 hasConceptScore W2018935611C2779306812 @default.
- W2018935611 hasConceptScore W2018935611C2779489039 @default.
- W2018935611 hasConceptScore W2018935611C2779895986 @default.
- W2018935611 hasConceptScore W2018935611C501593827 @default.
- W2018935611 hasConceptScore W2018935611C523546767 @default.
- W2018935611 hasConceptScore W2018935611C54355233 @default.
- W2018935611 hasConceptScore W2018935611C55493867 @default.
- W2018935611 hasConceptScore W2018935611C86803240 @default.
- W2018935611 hasConceptScore W2018935611C89423630 @default.
- W2018935611 hasIssue "3" @default.
- W2018935611 hasLocation W20189356111 @default.
- W2018935611 hasLocation W20189356112 @default.
- W2018935611 hasLocation W20189356113 @default.
- W2018935611 hasOpenAccess W2018935611 @default.
- W2018935611 hasPrimaryLocation W20189356111 @default.
- W2018935611 hasRelatedWork W1893905942 @default.
- W2018935611 hasRelatedWork W2008352426 @default.
- W2018935611 hasRelatedWork W2017741425 @default.
- W2018935611 hasRelatedWork W2052779789 @default.
- W2018935611 hasRelatedWork W2071136414 @default.
- W2018935611 hasRelatedWork W2109148136 @default.
- W2018935611 hasRelatedWork W2123750465 @default.
- W2018935611 hasRelatedWork W2331932260 @default.
- W2018935611 hasRelatedWork W2920362644 @default.
- W2018935611 hasRelatedWork W3159841555 @default.
- W2018935611 hasVolume "27" @default.
- W2018935611 isParatext "false" @default.
- W2018935611 isRetracted "false" @default.
- W2018935611 magId "2018935611" @default.
- W2018935611 workType "article" @default.