FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018947904> ?p ?o ?g. }

• W2018947904 endingPage "63" @default.
• W2018947904 startingPage "55" @default.
• W2018947904 abstract "The 3p14.2 chromosome region, which contains the FHIT gene and the FRA3B fragile site, is frequently altered in carcinomas. We analyzed the expression of the FHIT gene in 21 Burkitt's lymphoma cell lines and normal lymphoid populations. Seventeen (80%) of these cell lines had a common aberrant FHIT transcript as well as the normal transcript. Exon 2 was often aberrantly spliced to several coding exons, skipping exons 3 and 4, which overlap FRA3B. Other aberrant transcripts lacked exons 4–7 or exons 5–8. Exon 5, which has the initiation codon, was the most commonly affected. In two cell lines, Raji and KK124, there were aberrant transcripts retaining only the coding exons, which were able to make a normal protein, as demonstrated by in vitro transcription-translation analysis. In these aberrant messages, the additional deletion of 11 nucleotides at the beginning of exon 10 resulted in loss of translation. The cell line Ramos did not have a normal transcript. Some transcripts had common insertions of unknown origin that replaced coding exons, mainly exons 6 and 7. None of these aberrant messages coded for a protein, whether normal or aberrant. Within an individual cell line, aberrant messages appeared to result from sequential splicing reactions of a transcriptional unit derived from one allele. There was no correlation between aberrant FHIT transcription and the type of Burkitt's lymphoma regarding chromosomal translocation or presence of Epstein-Barr virus. In normal tonsils, spleen, and peripheral blood lymphocytes, aberrant transcripts were not detected and might represent a very minor subpopulation if detectable. Mol. Carcinog. 25:55–63, 1999. © 1999 Wiley-Liss, Inc." @default.
• W2018947904 created "2016-06-24" @default.
• W2018947904 creator A5005503867 @default.
• W2018947904 creator A5011280844 @default.
• W2018947904 creator A5063810021 @default.
• W2018947904 date "1999-05-01" @default.
• W2018947904 modified "2023-09-30" @default.
• W2018947904 title "Expression of aberrant functional and nonfunctional transcripts of theFHIT gene in Burkitt's lymphomas" @default.
• W2018947904 cites W1853273344 @default.
• W2018947904 cites W1964408981 @default.
• W2018947904 cites W1966502640 @default.
• W2018947904 cites W1968553547 @default.
• W2018947904 cites W1969418387 @default.
• W2018947904 cites W1969817641 @default.
• W2018947904 cites W1977715435 @default.
• W2018947904 cites W1989951007 @default.
• W2018947904 cites W2003240475 @default.
• W2018947904 cites W2017384019 @default.
• W2018947904 cites W2025382405 @default.
• W2018947904 cites W2038567850 @default.
• W2018947904 cites W2039105952 @default.
• W2018947904 cites W2042486508 @default.
• W2018947904 cites W2045396129 @default.
• W2018947904 cites W2051311335 @default.
• W2018947904 cites W2061445402 @default.
• W2018947904 cites W2067238706 @default.
• W2018947904 cites W2084899119 @default.
• W2018947904 cites W2094010209 @default.
• W2018947904 cites W2107202569 @default.
• W2018947904 cites W2141370108 @default.
• W2018947904 cites W2154930974 @default.
• W2018947904 cites W2443960935 @default.
• W2018947904 cites W4241815073 @default.
• W2018947904 doi "https://doi.org/10.1002/(sici)1098-2744(199905)25:1<55::aid-mc7>3.0.co;2-3" @default.
• W2018947904 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10331745" @default.
• W2018947904 hasPublicationYear "1999" @default.
• W2018947904 type Work @default.
• W2018947904 sameAs 2018947904 @default.
• W2018947904 citedByCount "8" @default.
• W2018947904 crossrefType "journal-article" @default.
• W2018947904 hasAuthorship W2018947904A5005503867 @default.
• W2018947904 hasAuthorship W2018947904A5011280844 @default.
• W2018947904 hasAuthorship W2018947904A5063810021 @default.
• W2018947904 hasConcept C104317684 @default.
• W2018947904 hasConcept C138885662 @default.
• W2018947904 hasConcept C143589142 @default.
• W2018947904 hasConcept C153911025 @default.
• W2018947904 hasConcept C156446351 @default.
• W2018947904 hasConcept C179926584 @default.
• W2018947904 hasConcept C180754005 @default.
• W2018947904 hasConcept C194583182 @default.
• W2018947904 hasConcept C2778264664 @default.
• W2018947904 hasConcept C2780646079 @default.
• W2018947904 hasConcept C30481170 @default.
• W2018947904 hasConcept C36823959 @default.
• W2018947904 hasConcept C41895202 @default.
• W2018947904 hasConcept C54355233 @default.
• W2018947904 hasConcept C54458228 @default.
• W2018947904 hasConcept C555283112 @default.
• W2018947904 hasConcept C60449816 @default.
• W2018947904 hasConcept C67705224 @default.
• W2018947904 hasConcept C86803240 @default.
• W2018947904 hasConceptScore W2018947904C104317684 @default.
• W2018947904 hasConceptScore W2018947904C138885662 @default.
• W2018947904 hasConceptScore W2018947904C143589142 @default.
• W2018947904 hasConceptScore W2018947904C153911025 @default.
• W2018947904 hasConceptScore W2018947904C156446351 @default.
• W2018947904 hasConceptScore W2018947904C179926584 @default.
• W2018947904 hasConceptScore W2018947904C180754005 @default.
• W2018947904 hasConceptScore W2018947904C194583182 @default.
• W2018947904 hasConceptScore W2018947904C2778264664 @default.
• W2018947904 hasConceptScore W2018947904C2780646079 @default.
• W2018947904 hasConceptScore W2018947904C30481170 @default.
• W2018947904 hasConceptScore W2018947904C36823959 @default.
• W2018947904 hasConceptScore W2018947904C41895202 @default.
• W2018947904 hasConceptScore W2018947904C54355233 @default.
• W2018947904 hasConceptScore W2018947904C54458228 @default.
• W2018947904 hasConceptScore W2018947904C555283112 @default.
• W2018947904 hasConceptScore W2018947904C60449816 @default.
• W2018947904 hasConceptScore W2018947904C67705224 @default.
• W2018947904 hasConceptScore W2018947904C86803240 @default.
• W2018947904 hasIssue "1" @default.
• W2018947904 hasLocation W20189479041 @default.
• W2018947904 hasLocation W20189479042 @default.
• W2018947904 hasOpenAccess W2018947904 @default.
• W2018947904 hasPrimaryLocation W20189479041 @default.
• W2018947904 hasRelatedWork W1573549078 @default.
• W2018947904 hasRelatedWork W1984349060 @default.
• W2018947904 hasRelatedWork W1993051407 @default.
• W2018947904 hasRelatedWork W2005929266 @default.
• W2018947904 hasRelatedWork W2018947904 @default.
• W2018947904 hasRelatedWork W2046690258 @default.
• W2018947904 hasRelatedWork W2085975240 @default.
• W2018947904 hasRelatedWork W2090999728 @default.
• W2018947904 hasRelatedWork W2147652847 @default.
• W2018947904 hasRelatedWork W2520430930 @default.
• W2018947904 hasVolume "25" @default.
• W2018947904 isParatext "false" @default.

• next