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• W2018948302 endingPage "209" @default.
• W2018948302 startingPage "199" @default.
• W2018948302 abstract "Intestinal homeostasis is dependent on the proper host/microbiota interaction via pattern recognition receptors. Toll-like receptors are a specialised group of membrane receptors which detect pathogen-associated conserved structures. They are present in the intestinal tract and are required for intestinal homeostasis. Dysregulation in the Toll-like receptor signalling can conceivably result in a dysregulated immune response which could contribute to major intestinal pathologies including colorectal cancer. Evidence for the role of microbiota and toll-like receptors in colorectal cancer is emerging. In this report the evidence for the contribution of toll-like receptors to the pathogenesis of colorectal cancer; potential mechanisms affecting toll-like receptor signalling; and their therapeutic targeting in colorectal cancer are reviewed." @default.
• W2018948302 created "2016-06-24" @default.
• W2018948302 creator A5020678911 @default.
• W2018948302 creator A5043880029 @default.
• W2018948302 date "2013-06-01" @default.
• W2018948302 modified "2023-09-25" @default.
• W2018948302 title "Toll-like receptor signalling and their therapeutic targeting in colorectal cancer" @default.
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