Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018950190> ?p ?o ?g. }
Showing items 1 to 79 of
79
with 100 items per page.
- W2018950190 abstract "Nitric oxide (NO) is an important second messenger, involved in the implementation of various cell functions. It regulates various physiological and pathological processes such as neurotransmission, cell responses to stress, and neurodegeneration. NO synthase is a family of enzymes that synthesize NO from L-arginine. The activity of different NOS isoforms depends both on endogenous and exogenous factors. In particular, it is modulated by oxidative stress, induced by photodynamic therapy (PDT). We have studied the possible role of NOS in the regulation of survival and death of neurons and surrounding glial cells under photo-oxidative stress induced by photodynamic treatment (PDT). The crayfish stretch receptor consisting of a single identified sensory neuron enveloped by glial cells is a simple but informative model object. It was photosensitized with alumophthalocyanine photosens (10 nM) and irradiated with a laser diode (670 nm, 0.4 W/cm2). Antinecrotic and proapoptotic effects of NO on the glial cells were found using inhibitory analysis. We have shown the role of inducible NO synthase in photoinduced apoptosis and involvement of neuronal NO synthase in photoinduced necrosis of glial cells in the isolated crayfish stretch receptor. The activation of NO synthase was evaluated using NADPH-diaphorase histochemistry, a marker of neurons expressing the enzyme. The activation of NO synthase in the isolated crayfish stretch receptor was evaluated as a function of time after PDT. Photodynamic treatment induced transient increase in NO synthase activity and then slowly inhibited this enzyme." @default.
- W2018950190 created "2016-06-24" @default.
- W2018950190 creator A5023647654 @default.
- W2018950190 creator A5025436392 @default.
- W2018950190 creator A5068349825 @default.
- W2018950190 date "2015-03-19" @default.
- W2018950190 modified "2023-09-23" @default.
- W2018950190 title "The role of NO synthase isoforms in PDT-induced injury of neurons and glial cells" @default.
- W2018950190 cites W1969213104 @default.
- W2018950190 cites W2005494498 @default.
- W2018950190 cites W2033360475 @default.
- W2018950190 cites W2035464530 @default.
- W2018950190 cites W2039435441 @default.
- W2018950190 cites W2043005431 @default.
- W2018950190 cites W2043749799 @default.
- W2018950190 cites W2076824965 @default.
- W2018950190 cites W2080456397 @default.
- W2018950190 cites W2091739837 @default.
- W2018950190 cites W2096680191 @default.
- W2018950190 cites W2115914766 @default.
- W2018950190 cites W4236184533 @default.
- W2018950190 cites W4241255428 @default.
- W2018950190 cites W4244997660 @default.
- W2018950190 doi "https://doi.org/10.1117/12.2179702" @default.
- W2018950190 hasPublicationYear "2015" @default.
- W2018950190 type Work @default.
- W2018950190 sameAs 2018950190 @default.
- W2018950190 citedByCount "0" @default.
- W2018950190 crossrefType "proceedings-article" @default.
- W2018950190 hasAuthorship W2018950190A5023647654 @default.
- W2018950190 hasAuthorship W2018950190A5025436392 @default.
- W2018950190 hasAuthorship W2018950190A5068349825 @default.
- W2018950190 hasConcept C112243037 @default.
- W2018950190 hasConcept C126322002 @default.
- W2018950190 hasConcept C169760540 @default.
- W2018950190 hasConcept C170493617 @default.
- W2018950190 hasConcept C181199279 @default.
- W2018950190 hasConcept C185592680 @default.
- W2018950190 hasConcept C2776151105 @default.
- W2018950190 hasConcept C2776925932 @default.
- W2018950190 hasConcept C2777622882 @default.
- W2018950190 hasConcept C2778794669 @default.
- W2018950190 hasConcept C2779134260 @default.
- W2018950190 hasConcept C55493867 @default.
- W2018950190 hasConcept C71924100 @default.
- W2018950190 hasConcept C86803240 @default.
- W2018950190 hasConcept C95444343 @default.
- W2018950190 hasConceptScore W2018950190C112243037 @default.
- W2018950190 hasConceptScore W2018950190C126322002 @default.
- W2018950190 hasConceptScore W2018950190C169760540 @default.
- W2018950190 hasConceptScore W2018950190C170493617 @default.
- W2018950190 hasConceptScore W2018950190C181199279 @default.
- W2018950190 hasConceptScore W2018950190C185592680 @default.
- W2018950190 hasConceptScore W2018950190C2776151105 @default.
- W2018950190 hasConceptScore W2018950190C2776925932 @default.
- W2018950190 hasConceptScore W2018950190C2777622882 @default.
- W2018950190 hasConceptScore W2018950190C2778794669 @default.
- W2018950190 hasConceptScore W2018950190C2779134260 @default.
- W2018950190 hasConceptScore W2018950190C55493867 @default.
- W2018950190 hasConceptScore W2018950190C71924100 @default.
- W2018950190 hasConceptScore W2018950190C86803240 @default.
- W2018950190 hasConceptScore W2018950190C95444343 @default.
- W2018950190 hasLocation W20189501901 @default.
- W2018950190 hasOpenAccess W2018950190 @default.
- W2018950190 hasPrimaryLocation W20189501901 @default.
- W2018950190 hasRelatedWork W1990738873 @default.
- W2018950190 hasRelatedWork W1997198091 @default.
- W2018950190 hasRelatedWork W2075259586 @default.
- W2018950190 hasRelatedWork W2088627748 @default.
- W2018950190 hasRelatedWork W2133064681 @default.
- W2018950190 hasRelatedWork W2159169453 @default.
- W2018950190 hasRelatedWork W2379517149 @default.
- W2018950190 hasRelatedWork W2780192089 @default.
- W2018950190 hasRelatedWork W3008542738 @default.
- W2018950190 hasRelatedWork W4327811798 @default.
- W2018950190 isParatext "false" @default.
- W2018950190 isRetracted "false" @default.
- W2018950190 magId "2018950190" @default.
- W2018950190 workType "article" @default.