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- W2018950721 abstract "Abstract Triglycerides of deuterium‐labeled trans ‐11‐, trans ‐11‐ cis ‐11‐ and cis ‐9‐octadecenoic acid (11t‐18∶1‐ 2 H, 11c‐18∶1‐ 2 H) were simultaneously fed to two young adult male subjects. Plasma lipids from blood samples collected periodically for 48 hr were analyzed by gas chromatography‐mass spectroscopy. The results indicate (i) the Δ11‐18∶1‐ 2 H acids and 9c‐18∶1‐ 2 H were equally well absorbed; (ii) relative turnover rates were higher for the Δ11‐18‐1‐ 2 H acids in plasma triglycerides; (iii) incorporation of the Δ11‐18∶1‐ 2 H acids into plasma phosphatidylcholine was similar to 9c‐18∶1‐ 2 H, but distribution at the 1‐and 2‐acyl positions was substantially different; (iv) esterification of cholesterol with 11t‐18∶1 was extremely low; (v) chain shortening of the Δ11‐18∶1‐ 2 H acids was 2–3 times greater than for 9c‐18∶1‐ 2 H; (vi) no evidence for desaturation or elongation of the 18∶1‐ 2 H acids was detected; and (vii) a 40% isotopic dilution of the 18∶1‐ 2 H acids in the chylomicron triglyceride fraction indicated the presence of a substantial intestinal triglyceride pool. Based on our present knowledge, these metabolic results for Δ11‐18∶1 acids present in hydrogenated oils and animal fats indicate that the Δ11 isomers are no more likely than 9c‐18∶1 to contribute to dietary fat‐related health problems." @default.
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- W2018950721 date "1986-09-01" @default.
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- W2018950721 title "Absorption and distribution of deuterium-labeledtrans- andcis-11-octadecenoic acid in human plasma and lipoprotein lipids" @default.
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