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• W2018954884 abstract "Purpose To analyze the relationship between storage time of split donor tissue and outcomes after deep anterior lamellar keratoplasty (DALK) and Descemet's membrane endothelial keratoplasty (DMEK). Design Retrospective analysis of a nonrandomized, consecutive, interventional case series. Participants One hundred ten eyes with anterior stromal disease suitable for DALK and 110 eyes with endothelial disease suitable for DMEK underwent surgically successful split cornea transplantation combining both procedures within 7 days after splitting. Methods Split donor storage times (splitting to grafting) and total storage times (death to grafting) were correlated with the 1-year functional and morphologic outcomes after DALK and DMEK surgery using a Spearman correlation coefficient and a Mann–Whitney U test. Main Outcome Measures Best spectacle-corrected visual acuity (BSCVA), endothelial cell density, and complication rates within 12 months of follow-up. Results The mean split donor storage time was 35±47 hours (range, 0–162 hours) after splitting for anterior donor grafts and 21±40 hours (range, 0–158 hours) for posterior grafts. The mean total storage time was 352±108 hours (range, 108–678 hours) for anterior lamellas and 339±109 hours (range, 96–630 hours) for posterior lamellas. One year after DALK, the mean BSCVA was 20/30 (range, 20/50–20/20), endothelial cell loss was 8% (range, 2%–16%), and the complication rate (Descemet's folds, epitheliopathy, loose sutures) was 18%. One year after DMEK, the mean BSCVA was 20/25 (range, 20/40–20/16), endothelial cell loss was 41% (range, 17%–63%), and the complication rate (partial graft detachment) was 62%. For DALK and DMEK, no significant association was observed between split donor storage time as well as total storage time and BSCVA (P≥0.409), endothelial cell loss (P≥0.236), or complication rate (P≥0.647) within 1 year of follow-up. Conclusions Anterior and posterior donor tissue may be stored safely for up to 1 week in organ culture before use in DALK and DMEK surgery. This simplifies the clinical feasibility of split cornea transplantation to reduce donor shortage and cost in corneal transplantation in the future. Financial Disclosure(s) The author(s) have no proprietary or commercial interest in any materials discussed in this article. To analyze the relationship between storage time of split donor tissue and outcomes after deep anterior lamellar keratoplasty (DALK) and Descemet's membrane endothelial keratoplasty (DMEK). Retrospective analysis of a nonrandomized, consecutive, interventional case series. One hundred ten eyes with anterior stromal disease suitable for DALK and 110 eyes with endothelial disease suitable for DMEK underwent surgically successful split cornea transplantation combining both procedures within 7 days after splitting. Split donor storage times (splitting to grafting) and total storage times (death to grafting) were correlated with the 1-year functional and morphologic outcomes after DALK and DMEK surgery using a Spearman correlation coefficient and a Mann–Whitney U test. Best spectacle-corrected visual acuity (BSCVA), endothelial cell density, and complication rates within 12 months of follow-up. The mean split donor storage time was 35±47 hours (range, 0–162 hours) after splitting for anterior donor grafts and 21±40 hours (range, 0–158 hours) for posterior grafts. The mean total storage time was 352±108 hours (range, 108–678 hours) for anterior lamellas and 339±109 hours (range, 96–630 hours) for posterior lamellas. One year after DALK, the mean BSCVA was 20/30 (range, 20/50–20/20), endothelial cell loss was 8% (range, 2%–16%), and the complication rate (Descemet's folds, epitheliopathy, loose sutures) was 18%. One year after DMEK, the mean BSCVA was 20/25 (range, 20/40–20/16), endothelial cell loss was 41% (range, 17%–63%), and the complication rate (partial graft detachment) was 62%. For DALK and DMEK, no significant association was observed between split donor storage time as well as total storage time and BSCVA (P≥0.409), endothelial cell loss (P≥0.236), or complication rate (P≥0.647) within 1 year of follow-up. Anterior and posterior donor tissue may be stored safely for up to 1 week in organ culture before use in DALK and DMEK surgery. This simplifies the clinical feasibility of split cornea transplantation to reduce donor shortage and cost in corneal transplantation in the future." @default.
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• W2018954884 date "2013-05-01" @default.
• W2018954884 modified "2023-10-12" @default.
• W2018954884 title "Split Cornea Transplantation" @default.
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