Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018958047> ?p ?o ?g. }
- W2018958047 endingPage "1105" @default.
- W2018958047 startingPage "1095" @default.
- W2018958047 abstract "Inflammation appears to play a key role in the development of colorectal cancer (CRC). In this study we examine factors involved in the regulation of inflammation and risk of CRC. Data from a multi-center case–control study of colon (N = 1579 cases and N = 1977 controls) and rectal (N = 794 cases and N = 1005 controls) cancer were used to evaluate the association between the rs1800795 and rs1800796 IL6 polymorphisms and CRC. We evaluated the joint effects of IL6 single nucleotide polymorphisms and regular use of aspirin/NSAIDs and vitamin D receptor (VDR) genotype. Having a C allele of the rs1800796 IL6 polymorphisms and the GG genotype of the rs1800795 IL6 polymorphisms was associated with a statistically significantly reduced the risk of colon (OR 0.76 95% CI 0.57, 1.00), but not rectal (OR 1.49 95% CI 1.02,2.16) cancer. Both IL6 polymorphisms were associated with significant interaction with current use of aspirin/NSAIDs to alter risk of colon cancer: individuals with a C allele in either polymorphism who were current users of aspirin/NSAIDs had the lowest colon cancer risk. CRC risk also was associated with an interaction between VDR and IL6 genotypes that was modified by current use of aspirin/NSAIDs. This study provides further support for inflammation-related factors in the etiology of CRC. Other studies are needed to explore other genes in this and other inflammation-related pathways." @default.
- W2018958047 created "2016-06-24" @default.
- W2018958047 creator A5048819576 @default.
- W2018958047 creator A5059108165 @default.
- W2018958047 creator A5060833617 @default.
- W2018958047 creator A5073774490 @default.
- W2018958047 creator A5082578863 @default.
- W2018958047 date "2007-08-13" @default.
- W2018958047 modified "2023-10-07" @default.
- W2018958047 title "IL6 genotypes and colon and rectal cancer" @default.
- W2018958047 cites W1517245545 @default.
- W2018958047 cites W173769312 @default.
- W2018958047 cites W1928411162 @default.
- W2018958047 cites W1967809201 @default.
- W2018958047 cites W1975217765 @default.
- W2018958047 cites W1982826185 @default.
- W2018958047 cites W1985297370 @default.
- W2018958047 cites W1988738875 @default.
- W2018958047 cites W1989554921 @default.
- W2018958047 cites W1999534333 @default.
- W2018958047 cites W1999654100 @default.
- W2018958047 cites W2011672691 @default.
- W2018958047 cites W2011924809 @default.
- W2018958047 cites W2016170751 @default.
- W2018958047 cites W2028194167 @default.
- W2018958047 cites W2031418790 @default.
- W2018958047 cites W2031637294 @default.
- W2018958047 cites W2038833705 @default.
- W2018958047 cites W2046072702 @default.
- W2018958047 cites W204661247 @default.
- W2018958047 cites W2047005855 @default.
- W2018958047 cites W2051153504 @default.
- W2018958047 cites W2056117410 @default.
- W2018958047 cites W2078052483 @default.
- W2018958047 cites W2080436457 @default.
- W2018958047 cites W2085615121 @default.
- W2018958047 cites W2085757616 @default.
- W2018958047 cites W2085866528 @default.
- W2018958047 cites W2087991334 @default.
- W2018958047 cites W2089022749 @default.
- W2018958047 cites W2089325126 @default.
- W2018958047 cites W2090291235 @default.
- W2018958047 cites W2098388063 @default.
- W2018958047 cites W2099691945 @default.
- W2018958047 cites W2105677103 @default.
- W2018958047 cites W2106044877 @default.
- W2018958047 cites W2107131154 @default.
- W2018958047 cites W2111275015 @default.
- W2018958047 cites W2111952114 @default.
- W2018958047 cites W2113184924 @default.
- W2018958047 cites W2121484716 @default.
- W2018958047 cites W2124732757 @default.
- W2018958047 cites W2133327838 @default.
- W2018958047 cites W2135088652 @default.
- W2018958047 cites W2136083733 @default.
- W2018958047 cites W2141035073 @default.
- W2018958047 cites W2154902953 @default.
- W2018958047 cites W2162288503 @default.
- W2018958047 cites W2167304096 @default.
- W2018958047 cites W2168458974 @default.
- W2018958047 cites W2188798267 @default.
- W2018958047 cites W2189513341 @default.
- W2018958047 cites W2192080449 @default.
- W2018958047 cites W2243911249 @default.
- W2018958047 cites W2324962687 @default.
- W2018958047 cites W238827458 @default.
- W2018958047 cites W2418985901 @default.
- W2018958047 cites W4246592598 @default.
- W2018958047 doi "https://doi.org/10.1007/s10552-007-9049-x" @default.
- W2018958047 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2442470" @default.
- W2018958047 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17694420" @default.
- W2018958047 hasPublicationYear "2007" @default.
- W2018958047 type Work @default.
- W2018958047 sameAs 2018958047 @default.
- W2018958047 citedByCount "100" @default.
- W2018958047 countsByYear W20189580472012 @default.
- W2018958047 countsByYear W20189580472013 @default.
- W2018958047 countsByYear W20189580472014 @default.
- W2018958047 countsByYear W20189580472015 @default.
- W2018958047 countsByYear W20189580472016 @default.
- W2018958047 countsByYear W20189580472017 @default.
- W2018958047 countsByYear W20189580472018 @default.
- W2018958047 countsByYear W20189580472019 @default.
- W2018958047 countsByYear W20189580472020 @default.
- W2018958047 countsByYear W20189580472021 @default.
- W2018958047 countsByYear W20189580472022 @default.
- W2018958047 countsByYear W20189580472023 @default.
- W2018958047 crossrefType "journal-article" @default.
- W2018958047 hasAuthorship W2018958047A5048819576 @default.
- W2018958047 hasAuthorship W2018958047A5059108165 @default.
- W2018958047 hasAuthorship W2018958047A5060833617 @default.
- W2018958047 hasAuthorship W2018958047A5073774490 @default.
- W2018958047 hasAuthorship W2018958047A5082578863 @default.
- W2018958047 hasBestOaLocation W20189580472 @default.
- W2018958047 hasConcept C104317684 @default.
- W2018958047 hasConcept C121608353 @default.
- W2018958047 hasConcept C124490489 @default.
- W2018958047 hasConcept C126322002 @default.