FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018960097> ?p ?o ?g. }

• W2018960097 endingPage "3073" @default.
• W2018960097 startingPage "3065" @default.
• W2018960097 abstract "A group of proteins with cell membrane remodeling properties is also able to change dramatically the morphology of liposomes in vitro, frequently inducing tubulation. For a number of these proteins, the mechanism by which this effect is exerted has been proposed to be the embedding of amphipathic helices into the lipid bilayer. For proteins presenting BAR domains, removal of an N-terminal amphipathic alpha-helix (H0-NBAR) results in much lower membrane tubulation efficiency, pointing to a fundamental role of this protein segment. Here, we studied the interaction of a peptide corresponding to H0-NBAR with model lipid membranes. H0-NBAR bound avidly to anionic liposomes but partitioned weakly to zwitterionic bilayers, suggesting an essentially electrostatic interaction with the lipid bilayer. Interestingly, it is shown that after membrane incorporation, the peptide oligomerizes as an antiparallel dimer, suggesting a potential role of H0-NBAR in the mediation of BAR domain oligomerization. Through monitoring the effect of H0-NBAR on liposome shape by cryoelectron microscopy, it is clear that membrane morphology is not radically changed. We conclude that H0-NBAR alone is not able to induce vesicle curvature, and its function must be related to the promotion of the scaffold effect provided by the concave surface of the BAR domain." @default.
• W2018960097 created "2016-06-24" @default.
• W2018960097 creator A5047677063 @default.
• W2018960097 creator A5048872989 @default.
• W2018960097 creator A5055251025 @default.
• W2018960097 creator A5060925042 @default.
• W2018960097 creator A5084450822 @default.
• W2018960097 creator A5087922737 @default.
• W2018960097 date "2008-04-01" @default.
• W2018960097 modified "2023-10-12" @default.
• W2018960097 title "Role of Helix 0 of the N-BAR Domain in Membrane Curvature Generation" @default.
• W2018960097 cites W1968827252 @default.
• W2018960097 cites W1975423157 @default.
• W2018960097 cites W1977292998 @default.
• W2018960097 cites W1977951612 @default.
• W2018960097 cites W1986516374 @default.
• W2018960097 cites W1997719326 @default.
• W2018960097 cites W2005312734 @default.
• W2018960097 cites W2007483105 @default.
• W2018960097 cites W2011200499 @default.
• W2018960097 cites W2018852886 @default.
• W2018960097 cites W2042776102 @default.
• W2018960097 cites W2043288164 @default.
• W2018960097 cites W2055843630 @default.
• W2018960097 cites W2066978513 @default.
• W2018960097 cites W2069113791 @default.
• W2018960097 cites W2071877471 @default.
• W2018960097 cites W2072167784 @default.
• W2018960097 cites W2078009233 @default.
• W2018960097 cites W2107016928 @default.
• W2018960097 cites W2108454910 @default.
• W2018960097 cites W2108586733 @default.
• W2018960097 cites W2114628856 @default.
• W2018960097 cites W2117649547 @default.
• W2018960097 cites W2132606840 @default.
• W2018960097 cites W2138532798 @default.
• W2018960097 cites W2147572547 @default.
• W2018960097 cites W2169857435 @default.
• W2018960097 cites W31206901 @default.
• W2018960097 doi "https://doi.org/10.1529/biophysj.107.113118" @default.
• W2018960097 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2275701" @default.
• W2018960097 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18199667" @default.
• W2018960097 hasPublicationYear "2008" @default.
• W2018960097 type Work @default.
• W2018960097 sameAs 2018960097 @default.
• W2018960097 citedByCount "56" @default.
• W2018960097 countsByYear W20189600972012 @default.
• W2018960097 countsByYear W20189600972013 @default.
• W2018960097 countsByYear W20189600972014 @default.
• W2018960097 countsByYear W20189600972015 @default.
• W2018960097 countsByYear W20189600972016 @default.
• W2018960097 countsByYear W20189600972017 @default.
• W2018960097 countsByYear W20189600972018 @default.
• W2018960097 countsByYear W20189600972019 @default.
• W2018960097 countsByYear W20189600972020 @default.
• W2018960097 countsByYear W20189600972021 @default.
• W2018960097 countsByYear W20189600972022 @default.
• W2018960097 crossrefType "journal-article" @default.
• W2018960097 hasAuthorship W2018960097A5047677063 @default.
• W2018960097 hasAuthorship W2018960097A5048872989 @default.
• W2018960097 hasAuthorship W2018960097A5055251025 @default.
• W2018960097 hasAuthorship W2018960097A5060925042 @default.
• W2018960097 hasAuthorship W2018960097A5084450822 @default.
• W2018960097 hasAuthorship W2018960097A5087922737 @default.
• W2018960097 hasBestOaLocation W20189600971 @default.
• W2018960097 hasConcept C115260700 @default.
• W2018960097 hasConcept C121332964 @default.
• W2018960097 hasConcept C125501631 @default.
• W2018960097 hasConcept C12554922 @default.
• W2018960097 hasConcept C130316041 @default.
• W2018960097 hasConcept C142089489 @default.
• W2018960097 hasConcept C185154212 @default.
• W2018960097 hasConcept C185592680 @default.
• W2018960097 hasConcept C18903297 @default.
• W2018960097 hasConcept C192157962 @default.
• W2018960097 hasConcept C2777278457 @default.
• W2018960097 hasConcept C2778530040 @default.
• W2018960097 hasConcept C2779281246 @default.
• W2018960097 hasConcept C2779965526 @default.
• W2018960097 hasConcept C39944091 @default.
• W2018960097 hasConcept C41625074 @default.
• W2018960097 hasConcept C55493867 @default.
• W2018960097 hasConcept C62520636 @default.
• W2018960097 hasConcept C8010536 @default.
• W2018960097 hasConcept C86803240 @default.
• W2018960097 hasConceptScore W2018960097C115260700 @default.
• W2018960097 hasConceptScore W2018960097C121332964 @default.
• W2018960097 hasConceptScore W2018960097C125501631 @default.
• W2018960097 hasConceptScore W2018960097C12554922 @default.
• W2018960097 hasConceptScore W2018960097C130316041 @default.
• W2018960097 hasConceptScore W2018960097C142089489 @default.
• W2018960097 hasConceptScore W2018960097C185154212 @default.
• W2018960097 hasConceptScore W2018960097C185592680 @default.
• W2018960097 hasConceptScore W2018960097C18903297 @default.
• W2018960097 hasConceptScore W2018960097C192157962 @default.
• W2018960097 hasConceptScore W2018960097C2777278457 @default.
• W2018960097 hasConceptScore W2018960097C2778530040 @default.
• W2018960097 hasConceptScore W2018960097C2779281246 @default.

• next