FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018966412> ?p ?o ?g. }

• W2018966412 endingPage "366" @default.
• W2018966412 startingPage "357" @default.
• W2018966412 abstract "Rats with neonatal ventral hippocampal lesions (NVHL) have been studied as a neurodevelopmental animal model of schizophrenia. NVHL rats exhibit postpubertal emergence of hyperresponsiveness to stress, suggesting increased mesolimbic dopamine (DA) activity. However, previous studies have not yielded clear evidence of this. Disturbances in the gamma-amino-butyric acid (GABA)-ergic system as well as the dopaminergic system are thought to be present in schizophrenia. To determine whether GABA(A) receptors play a role in the abnormal postpubertal behavior in NVHL rats, we compared changes in expression of mRNA of GABA(A) receptor subunits and in [(35)S] t-butylbicyclophosphorothionate ([(35)S] TBPS) binding in the prepubertal and postpubertal periods. Male pups were lesioned with ibotenic acid at postnatal day 7 (PD 7), and in situ hybridization and quantitative autoradiography were then performed. In NVHL rats, alpha1 subunit mRNA expression in prefrontal cortex was decreased at PD 35 (prepubertal period; by 21.7%), but increased at PD 56 (postpubertal period; by 21.4%) when compared with sham controls. beta2 subunit mRNA expression was increased in PFC in the postpubertal period (by 24.3%). beta3 subunit mRNA expression was increased in the caudate-putamen in the postpubertal period (by 37.2%). [(35)S] TBPS binding was increased in PFC only in the postpubertal period (by 17.7%). These findings suggest that dysfunction of the GABAergic system exists in NVHL rats. Furthermore, developmental and regional changes in GABA(A) receptor expression appear to occur in compensation for the attenuation of GABAergic system activity in NVHL rats." @default.
• W2018966412 created "2016-06-24" @default.
• W2018966412 creator A5011996204 @default.
• W2018966412 creator A5031394499 @default.
• W2018966412 creator A5064840727 @default.
• W2018966412 creator A5067266617 @default.
• W2018966412 date "2007-01-01" @default.
• W2018966412 modified "2023-10-18" @default.
• W2018966412 title "Alterations in GABAA receptor expression in neonatal ventral hippocampal lesioned rats: Comparison of prepubertal and postpubertal periods" @default.
• W2018966412 cites W1524203275 @default.
• W2018966412 cites W1551663317 @default.
• W2018966412 cites W1570185216 @default.
• W2018966412 cites W1879000632 @default.
• W2018966412 cites W1882365212 @default.
• W2018966412 cites W1964240411 @default.
• W2018966412 cites W1967979754 @default.
• W2018966412 cites W1975682905 @default.
• W2018966412 cites W1975723323 @default.
• W2018966412 cites W1989993438 @default.
• W2018966412 cites W1990153313 @default.
• W2018966412 cites W1995384788 @default.
• W2018966412 cites W1999943185 @default.
• W2018966412 cites W2002782021 @default.
• W2018966412 cites W2003289804 @default.
• W2018966412 cites W2004425853 @default.
• W2018966412 cites W2004881650 @default.
• W2018966412 cites W2005432794 @default.
• W2018966412 cites W2005771695 @default.
• W2018966412 cites W2012245779 @default.
• W2018966412 cites W2012955582 @default.
• W2018966412 cites W2014188597 @default.
• W2018966412 cites W2026147700 @default.
• W2018966412 cites W2028747258 @default.
• W2018966412 cites W2030928110 @default.
• W2018966412 cites W2037628564 @default.
• W2018966412 cites W2040181871 @default.
• W2018966412 cites W2044533253 @default.
• W2018966412 cites W2050078067 @default.
• W2018966412 cites W2056372896 @default.
• W2018966412 cites W2065989494 @default.
• W2018966412 cites W2066474203 @default.
• W2018966412 cites W2066882561 @default.
• W2018966412 cites W2072060777 @default.
• W2018966412 cites W2072621056 @default.
• W2018966412 cites W2074564608 @default.
• W2018966412 cites W2077679777 @default.
• W2018966412 cites W2079524104 @default.
• W2018966412 cites W2083876585 @default.
• W2018966412 cites W2085875247 @default.
• W2018966412 cites W2088015625 @default.
• W2018966412 cites W2089912569 @default.
• W2018966412 cites W2092724863 @default.
• W2018966412 cites W2106001183 @default.
• W2018966412 cites W2111304405 @default.
• W2018966412 cites W2112444339 @default.
• W2018966412 cites W2154169426 @default.
• W2018966412 cites W2158137297 @default.
• W2018966412 cites W4298407382 @default.
• W2018966412 doi "https://doi.org/10.1002/syn.20393" @default.
• W2018966412 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17372969" @default.
• W2018966412 hasPublicationYear "2007" @default.
• W2018966412 type Work @default.
• W2018966412 sameAs 2018966412 @default.
• W2018966412 citedByCount "31" @default.
• W2018966412 countsByYear W20189664122012 @default.
• W2018966412 countsByYear W20189664122013 @default.
• W2018966412 countsByYear W20189664122014 @default.
• W2018966412 countsByYear W20189664122015 @default.
• W2018966412 countsByYear W20189664122016 @default.
• W2018966412 countsByYear W20189664122022 @default.
• W2018966412 crossrefType "journal-article" @default.
• W2018966412 hasAuthorship W2018966412A5011996204 @default.
• W2018966412 hasAuthorship W2018966412A5031394499 @default.
• W2018966412 hasAuthorship W2018966412A5064840727 @default.
• W2018966412 hasAuthorship W2018966412A5067266617 @default.
• W2018966412 hasConcept C104317684 @default.
• W2018966412 hasConcept C121332964 @default.
• W2018966412 hasConcept C126322002 @default.
• W2018966412 hasConcept C134018914 @default.
• W2018966412 hasConcept C137183658 @default.
• W2018966412 hasConcept C148762608 @default.
• W2018966412 hasConcept C150194340 @default.
• W2018966412 hasConcept C15744967 @default.
• W2018966412 hasConcept C168258287 @default.
• W2018966412 hasConcept C169760540 @default.
• W2018966412 hasConcept C169900460 @default.
• W2018966412 hasConcept C170493617 @default.
• W2018966412 hasConcept C17077164 @default.
• W2018966412 hasConcept C24890656 @default.
• W2018966412 hasConcept C2777681179 @default.
• W2018966412 hasConcept C2779177108 @default.
• W2018966412 hasConcept C2781161787 @default.
• W2018966412 hasConcept C2781195155 @default.
• W2018966412 hasConcept C2781291010 @default.
• W2018966412 hasConcept C513476851 @default.
• W2018966412 hasConcept C529278444 @default.
• W2018966412 hasConcept C55493867 @default.
• W2018966412 hasConcept C71924100 @default.

• next