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- W2018967352 abstract "Photoacoustic spectroscopy has the potential to make non-invasive, spatially resolved measurements of absolute chromophore concentrations. This has a wide range of possible applications, for example the mapping of endogenous chromophores such as oxy- (HbO 2 ) and deoxyhaemoglobin (HHb) or externally administered contrast agents designed to target specific tissues or molecular processes. In this study we used near-infrared photoacoustic spectroscopy to determine the absolute concentrations of HbO 2 and HHb in a tissue phantom. The phantom consisted of three blood filled capillaries (O460microns) suspended at depths between 3mm and 9mm in a 2.5% Intralipid solution which also contained 2% blood in order to simulate the background optical attenuation in biological tissue. The blood oxygen saturation (SO 2 ) of the blood circulating in the capillaries was varied using a membrane oxygenator. At each SO 2 level, nanosecond pulses emitted by an OPO laser system that was tuneable over the wavelength range from 740nm to 1040nm illuminated the phantom. The generated photoacoustic waves were recorded using a single Fabry-Perot ultrasound detector and used to obtain a depth profile of the location of the tubes. The amplitudes of the part of the photoacoustic signal that corresponded to the capillaries and the surface of the Intralipid/blood mixture were plotted as a function of wavelength. The output of a diffusion theory based model of the wavelength dependence of the photoacoustic signal amplitude was then fitted to these spectra. This enabled the quantitative determination of absolute HbO 2 and HHb concentrations in the capillaries and the Intralipid/blood mixture from which the total haemoglobin concentrations and blood SO 2 were calculated. Based on these measurements, the smallest chromophore concentrations that can be detected in biological tissue were estimated." @default.
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- W2018967352 date "2006-02-09" @default.
- W2018967352 modified "2023-09-23" @default.
- W2018967352 title "Absolute measurements of local chromophore concentrations using pulsed photoacoustic spectroscopy" @default.
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- W2018967352 doi "https://doi.org/10.1117/12.657372" @default.
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