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- W2018969908 abstract "Met-enkephalin (Met-enk) and substance P (SP) were measured by a combined high-performance liquid chromatography/radioimmunoanalysis method in medial (GPM) and lateral globus pallidus (GPL) from controls and from Parkinson's disease (PD) patients. All patients showed a similar marked (> 90%) reduction in dopamine (DA) levels in putamen compared with controls. However, based on DA levels in the caudate nucleus, two subgroups of PD patients were differentiated. In patients with > 80% decrease in caudate nucleus DA content, there was a three-fold increase in both Met-enk and SP levels in GPM. In contrast, in patients showing an approximately 50% reduction in DA content in caudate, levels of both peptides were markedly reduced (approximately 80%). Met-enk and SP levels in GPL were unchanged in PD. These results suggest that neurons containing Met-enk and SP projecting to GPM adapt according to the extent of degeneration in the substantia nigra in PD." @default.
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- W2018969908 date "1993-10-01" @default.
- W2018969908 modified "2023-09-28" @default.
- W2018969908 title "Parallel alterations in Met-enkephalin and substance P levels in medial globus pallidus in Parkinson's disease patients" @default.
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- W2018969908 doi "https://doi.org/10.1016/0304-3940(93)90404-9" @default.
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