FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018974033> ?p ?o ?g. }

• W2018974033 endingPage "1832" @default.
• W2018974033 startingPage "1827" @default.
• W2018974033 abstract "We examined the long-term sensitivity of uterus and bone to low-dose 17β-estradiol in a 4-month experiment in OVX rats and found that a dose of estradiol that fully protected against uterine atrophy did not protect against bone loss. Our results suggest higher estrogen sensitivity of the uterus compared with bone. Introduction: Estrogen is essential for the function of reproductive tissues and for the normal acquisition and maintenance of bone mass in females. This study was designed to examine the long-term sensitivity of the uterus and bone to low-dose estrogen. Materials and Methods: In preliminary experiments, we determined the lowest subcutaneous dose of 17β-estradiol able to fully protect against uterine atrophy in ovariectomized (OVX) rats. This dose was found to be 1.5 μg/kg, given five times per week. Subsequently, groups of sham-operated (SHAM) or OVX 6-month-old rats (n = 8 each) were subcutaneously injected with vehicle or 1.5 μg/kg 17β-estradiol five times per week. All animals were killed 4 months after surgery. Serum osteocalcin and urinary deoxypyridinoline were measured as biochemical markers of bone turnover. Bones were analyzed by bone histomorphometry and pQCT. Results and Conclusions: Our study clearly showed that a dose of estradiol that restores physiological estradiol serum levels, fully maintains uterine weight in OVX rats at the SHAM control level, and suppresses serum follicle-stimulating hormone (FSH) by 67% relative to OVX vehicle controls does not provide significant protection against OVX-induced bone loss at different cancellous and cortical bone sites. We conclude that the long-term sensitivity of the uterus and the hypothalamus/pituitary axis to 17β-estradiol is higher than that of bone in rats." @default.
• W2018974033 created "2016-06-24" @default.
• W2018974033 creator A5019562429 @default.
• W2018974033 creator A5036072779 @default.
• W2018974033 creator A5062610054 @default.
• W2018974033 date "2004-08-23" @default.
• W2018974033 modified "2023-10-10" @default.
• W2018974033 title "Long-Term Sensitivity of Uterus and Hypothalamus/Pituitary Axis to 17β-Estradiol Is Higher Than That of Bone in Rats" @default.
• W2018974033 cites W1562125623 @default.
• W2018974033 cites W1918671369 @default.
• W2018974033 cites W1928979506 @default.
• W2018974033 cites W1964815707 @default.
• W2018974033 cites W1965234498 @default.
• W2018974033 cites W1968327793 @default.
• W2018974033 cites W1970350174 @default.
• W2018974033 cites W1973795818 @default.
• W2018974033 cites W2001406070 @default.
• W2018974033 cites W2002987351 @default.
• W2018974033 cites W2015950286 @default.
• W2018974033 cites W2027093084 @default.
• W2018974033 cites W2032180255 @default.
• W2018974033 cites W2035409182 @default.
• W2018974033 cites W2040448057 @default.
• W2018974033 cites W2042065870 @default.
• W2018974033 cites W2044129473 @default.
• W2018974033 cites W2078888308 @default.
• W2018974033 cites W2104394944 @default.
• W2018974033 cites W2107131674 @default.
• W2018974033 cites W2124372891 @default.
• W2018974033 cites W2135678589 @default.
• W2018974033 cites W2149215117 @default.
• W2018974033 cites W2170484174 @default.
• W2018974033 doi "https://doi.org/10.1359/jbmr.040815" @default.
• W2018974033 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15476583" @default.
• W2018974033 hasPublicationYear "2004" @default.
• W2018974033 type Work @default.
• W2018974033 sameAs 2018974033 @default.
• W2018974033 citedByCount "14" @default.
• W2018974033 countsByYear W20189740332012 @default.
• W2018974033 countsByYear W20189740332015 @default.
• W2018974033 countsByYear W20189740332017 @default.
• W2018974033 countsByYear W20189740332022 @default.
• W2018974033 crossrefType "journal-article" @default.
• W2018974033 hasAuthorship W2018974033A5019562429 @default.
• W2018974033 hasAuthorship W2018974033A5036072779 @default.
• W2018974033 hasAuthorship W2018974033A5062610054 @default.
• W2018974033 hasBestOaLocation W20189740331 @default.
• W2018974033 hasConcept C105702510 @default.
• W2018974033 hasConcept C126322002 @default.
• W2018974033 hasConcept C131075544 @default.
• W2018974033 hasConcept C134018914 @default.
• W2018974033 hasConcept C160160445 @default.
• W2018974033 hasConcept C170033053 @default.
• W2018974033 hasConcept C181199279 @default.
• W2018974033 hasConcept C185592680 @default.
• W2018974033 hasConcept C2776350087 @default.
• W2018974033 hasConcept C2777164284 @default.
• W2018974033 hasConcept C2778575703 @default.
• W2018974033 hasConcept C2779066055 @default.
• W2018974033 hasConcept C2780787237 @default.
• W2018974033 hasConcept C2781172350 @default.
• W2018974033 hasConcept C2781451080 @default.
• W2018974033 hasConcept C55493867 @default.
• W2018974033 hasConcept C71315377 @default.
• W2018974033 hasConcept C71924100 @default.
• W2018974033 hasConcept C8264082 @default.
• W2018974033 hasConceptScore W2018974033C105702510 @default.
• W2018974033 hasConceptScore W2018974033C126322002 @default.
• W2018974033 hasConceptScore W2018974033C131075544 @default.
• W2018974033 hasConceptScore W2018974033C134018914 @default.
• W2018974033 hasConceptScore W2018974033C160160445 @default.
• W2018974033 hasConceptScore W2018974033C170033053 @default.
• W2018974033 hasConceptScore W2018974033C181199279 @default.
• W2018974033 hasConceptScore W2018974033C185592680 @default.
• W2018974033 hasConceptScore W2018974033C2776350087 @default.
• W2018974033 hasConceptScore W2018974033C2777164284 @default.
• W2018974033 hasConceptScore W2018974033C2778575703 @default.
• W2018974033 hasConceptScore W2018974033C2779066055 @default.
• W2018974033 hasConceptScore W2018974033C2780787237 @default.
• W2018974033 hasConceptScore W2018974033C2781172350 @default.
• W2018974033 hasConceptScore W2018974033C2781451080 @default.
• W2018974033 hasConceptScore W2018974033C55493867 @default.
• W2018974033 hasConceptScore W2018974033C71315377 @default.
• W2018974033 hasConceptScore W2018974033C71924100 @default.
• W2018974033 hasConceptScore W2018974033C8264082 @default.
• W2018974033 hasIssue "11" @default.
• W2018974033 hasLocation W20189740331 @default.
• W2018974033 hasLocation W20189740332 @default.
• W2018974033 hasOpenAccess W2018974033 @default.
• W2018974033 hasPrimaryLocation W20189740331 @default.
• W2018974033 hasRelatedWork W1967422973 @default.
• W2018974033 hasRelatedWork W2049146993 @default.
• W2018974033 hasRelatedWork W2053638911 @default.
• W2018974033 hasRelatedWork W2070386770 @default.
• W2018974033 hasRelatedWork W2128714854 @default.
• W2018974033 hasRelatedWork W2138014802 @default.
• W2018974033 hasRelatedWork W2156499301 @default.
• W2018974033 hasRelatedWork W2158977547 @default.

• next