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- W2018974154 abstract "A major component of Alzheimer's disease plaque amyloid β protein (βAP) showed the cytolytic activity to rat pheochromocytoma PC12 cells. Nuclear morphological study revealed that βAP-induced cytolytic activity is due to necrotic cell death, rather than apoptotic cell death. To examine the molecular machinery of βAP-induced necrotic cell death in detail, I investigated the direct involvement of caspase. When nerve growth factor-treated and -untreated PC12 cells were incubated with the synthesized tetrapeptide inhibitors of caspase, YVAD-CHO (Ac-Tyr-Val-Ala-Asp-CHO) or DEVD-CHO (Ac-Asp-Glu-Val-Asp-CHO), βAP-induced necrotic cell death was prevented. In addition, the interleukin-1β converting enzyme (ICE) subfamily activation preceded CPP32 subfamily activation during βAP-induced necrotic cell death. On the basis of these findings, I suggest that βAP induces necrotic cell death mediated by the ICE cascade and that the ICE cascade may possibly be involved in Alzheimer's disease." @default.
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- W2018974154 title "Amyloid β-protein Induces Necrotic Cell Death Mediated by ICE Cascade in PC12 Cells" @default.
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- W2018974154 doi "https://doi.org/10.1006/excr.1997.3639" @default.
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