FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018976166> ?p ?o ?g. }

• W2018976166 endingPage "212" @default.
• W2018976166 startingPage "207" @default.
• W2018976166 abstract "Extracellular-superoxide dismutase (EC-SOD) is the major SOD isozyme in the blood vessel walls and may be important for antioxidant capability of the vascular walls. Expression of EC-SOD is known to be regulated by numerous substances such as cytokines and vasoactive factors. Recently, we found that the plasma EC-SOD levels in type 2 diabetic patients were significantly and inversely related to indices of insulin resistance, whereas they were strongly and positively related to adiponectin. Administration of pioglitazone significantly increased the plasma level of EC-SOD and adiponectin. Transcription factors such as CCAAT/enhancer-binding proteins (C/EBPs) and peroxisome proliferator-activated receptors (PPARs) are known to regulate genes associated with insulin resistance. The aim of this study was to assess the contribution of these transcription factors on the EC-SOD level. We found that a C/EBPβ enhancer, prolactin, significantly induced the EC-SOD mRNA and protein levels in cultured fibroblast cell lines, but PPARγ ligands, pioglitazone and other thiazolidinedione agents did not. Deletion analysis of the EC-SOD promoter-luciferase construct showed that an important element responsible for prolactin is located between –242 and –178 in the promoter region of the EC-SOD gene in which a known C/EBPβ-binding site is located. Increasing the EC-SOD expression by treatment with ligands of transcription factors might be one approach to ameliorate the pathological conditions of insulin resistance." @default.
• W2018976166 created "2016-06-24" @default.
• W2018976166 creator A5016553000 @default.
• W2018976166 creator A5027506482 @default.
• W2018976166 creator A5035237000 @default.
• W2018976166 creator A5081038450 @default.
• W2018976166 date "2004-08-01" @default.
• W2018976166 modified "2023-10-08" @default.
• W2018976166 title "Effects of PPARγ ligands and C/EBPβ enhancer on expression of extracellular-superoxide dismutase" @default.
• W2018976166 cites W1482472937 @default.
• W2018976166 cites W1580883143 @default.
• W2018976166 cites W1898389524 @default.
• W2018976166 cites W1970637755 @default.
• W2018976166 cites W1970928392 @default.
• W2018976166 cites W1973792525 @default.
• W2018976166 cites W1974126557 @default.
• W2018976166 cites W1982806380 @default.
• W2018976166 cites W2003132777 @default.
• W2018976166 cites W2018522666 @default.
• W2018976166 cites W2020949125 @default.
• W2018976166 cites W2022377100 @default.
• W2018976166 cites W2026933757 @default.
• W2018976166 cites W2034289151 @default.
• W2018976166 cites W2042669405 @default.
• W2018976166 cites W2051370085 @default.
• W2018976166 cites W2072881410 @default.
• W2018976166 cites W2075231392 @default.
• W2018976166 cites W2079793296 @default.
• W2018976166 cites W2090399640 @default.
• W2018976166 cites W2096188544 @default.
• W2018976166 cites W2102844001 @default.
• W2018976166 cites W2108931588 @default.
• W2018976166 cites W2113553969 @default.
• W2018976166 cites W2117157033 @default.
• W2018976166 cites W2120612885 @default.
• W2018976166 cites W2127934772 @default.
• W2018976166 cites W2133813163 @default.
• W2018976166 cites W2138750223 @default.
• W2018976166 cites W2167866149 @default.
• W2018976166 doi "https://doi.org/10.1179/135100004225005985" @default.
• W2018976166 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15479564" @default.
• W2018976166 hasPublicationYear "2004" @default.
• W2018976166 type Work @default.
• W2018976166 sameAs 2018976166 @default.
• W2018976166 citedByCount "15" @default.
• W2018976166 countsByYear W20189761662012 @default.
• W2018976166 countsByYear W20189761662014 @default.
• W2018976166 countsByYear W20189761662018 @default.
• W2018976166 countsByYear W20189761662019 @default.
• W2018976166 crossrefType "journal-article" @default.
• W2018976166 hasAuthorship W2018976166A5016553000 @default.
• W2018976166 hasAuthorship W2018976166A5027506482 @default.
• W2018976166 hasAuthorship W2018976166A5035237000 @default.
• W2018976166 hasAuthorship W2018976166A5081038450 @default.
• W2018976166 hasConcept C104317684 @default.
• W2018976166 hasConcept C126322002 @default.
• W2018976166 hasConcept C134018914 @default.
• W2018976166 hasConcept C153911025 @default.
• W2018976166 hasConcept C170493617 @default.
• W2018976166 hasConcept C185592680 @default.
• W2018976166 hasConcept C187345961 @default.
• W2018976166 hasConcept C2775838275 @default.
• W2018976166 hasConcept C2776151105 @default.
• W2018976166 hasConcept C2776782570 @default.
• W2018976166 hasConcept C2777180221 @default.
• W2018976166 hasConcept C2777391703 @default.
• W2018976166 hasConcept C2778384471 @default.
• W2018976166 hasConcept C2779306644 @default.
• W2018976166 hasConcept C55493867 @default.
• W2018976166 hasConcept C555293320 @default.
• W2018976166 hasConcept C71924100 @default.
• W2018976166 hasConcept C86339819 @default.
• W2018976166 hasConcept C86803240 @default.
• W2018976166 hasConceptScore W2018976166C104317684 @default.
• W2018976166 hasConceptScore W2018976166C126322002 @default.
• W2018976166 hasConceptScore W2018976166C134018914 @default.
• W2018976166 hasConceptScore W2018976166C153911025 @default.
• W2018976166 hasConceptScore W2018976166C170493617 @default.
• W2018976166 hasConceptScore W2018976166C185592680 @default.
• W2018976166 hasConceptScore W2018976166C187345961 @default.
• W2018976166 hasConceptScore W2018976166C2775838275 @default.
• W2018976166 hasConceptScore W2018976166C2776151105 @default.
• W2018976166 hasConceptScore W2018976166C2776782570 @default.
• W2018976166 hasConceptScore W2018976166C2777180221 @default.
• W2018976166 hasConceptScore W2018976166C2777391703 @default.
• W2018976166 hasConceptScore W2018976166C2778384471 @default.
• W2018976166 hasConceptScore W2018976166C2779306644 @default.
• W2018976166 hasConceptScore W2018976166C55493867 @default.
• W2018976166 hasConceptScore W2018976166C555293320 @default.
• W2018976166 hasConceptScore W2018976166C71924100 @default.
• W2018976166 hasConceptScore W2018976166C86339819 @default.
• W2018976166 hasConceptScore W2018976166C86803240 @default.
• W2018976166 hasIssue "4" @default.
• W2018976166 hasLocation W20189761661 @default.
• W2018976166 hasLocation W20189761662 @default.
• W2018976166 hasOpenAccess W2018976166 @default.
• W2018976166 hasPrimaryLocation W20189761661 @default.
• W2018976166 hasRelatedWork W1979252938 @default.

• next