FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018982004> ?p ?o ?g. }

• W2018982004 endingPage "40" @default.
• W2018982004 startingPage "31" @default.
• W2018982004 abstract "Incubation of Chinese hamster lung (Dede) cells in medium containing 25-hydroxycholesterol resulted in the suppression of cellular cholesterol biosynthesis and a decrease in the cellular concentration of cholesterol so that the cholesterol/phospholipid molar ratio was reduced to approx. 50% of the control value. When these ‘sterol-depleted’ cells were allowed to attach to a serum-coated glass substratum, an inhibition of the rate and extent of attachment relative to the controls was observed. After 1 h incubation, only 10–25% of the 25-hydroxycholesterol-treated cells were attached, compared with virtually 100% of the control cells. Similar results were obtained with Chinese hamster ovary cells and with mouse L cells. Inhibition of adhesion was dependent upon the dose of—and time of exposure to—the oxygenated sterol. This inhibition was prevented when either cholesterol or mevalonic acid (the product of the enzymatic reaction inhibited by 25-hydroxycholesterol) was added with the 25-hydroxycholesterol, indicating that the effect of the sterol was primarily due to suppression of cholesterol synthesis. In addition, the inhibitor had no effect on the growth of a 25-hydroxycholesterol-resistant mutant or on the rate or extent of its adhesion to the substratum. Other oxygenated sterols (e.g. 22-ketocholesterol, 7β-hydroxycholesterol, 20α-hydryxycholesterol and 5α-cholest-8(14)-en-3β-ol-15-one) effected qualitatively similar inhibitions of the rates of sterol synthesis and cell-substratum attachment. The decreased adhesion observed when cultures were treated with inhibitors of cholesterol synthesis was not alleviated at low temperatures, suggesting that the effects of the inhibitor could not be overcome by a temperature-dependent increase in membrane viscosity. The rate and extent of adhesion of either Chinese hamster lung cells or L cell to several cell monolayers was also reduced in response to sterol depletion. These results suggest that membrane lipids, particularly cholesterol, play a significant role in cell-substratum and cell-cell adhesion." @default.
• W2018982004 created "2016-06-24" @default.
• W2018982004 creator A5038629754 @default.
• W2018982004 creator A5072507966 @default.
• W2018982004 creator A5081383773 @default.
• W2018982004 date "1981-01-01" @default.
• W2018982004 modified "2023-10-14" @default.
• W2018982004 title "Cell-substratum and cell-monolayer adhesion are dependent upon cellular cholesterol biosynthesis" @default.
• W2018982004 cites W1479976113 @default.
• W2018982004 cites W1497990315 @default.
• W2018982004 cites W1514004257 @default.
• W2018982004 cites W1520109431 @default.
• W2018982004 cites W1543557070 @default.
• W2018982004 cites W1544394834 @default.
• W2018982004 cites W1546119880 @default.
• W2018982004 cites W1757328638 @default.
• W2018982004 cites W1972677139 @default.
• W2018982004 cites W1980872330 @default.
• W2018982004 cites W1981861949 @default.
• W2018982004 cites W1985073282 @default.
• W2018982004 cites W1988954938 @default.
• W2018982004 cites W2009241314 @default.
• W2018982004 cites W2015559599 @default.
• W2018982004 cites W2032883933 @default.
• W2018982004 cites W2049291821 @default.
• W2018982004 cites W2068923686 @default.
• W2018982004 cites W2076165573 @default.
• W2018982004 cites W2078406520 @default.
• W2018982004 cites W2093366573 @default.
• W2018982004 cites W2094569055 @default.
• W2018982004 cites W2120225939 @default.
• W2018982004 cites W2135806900 @default.
• W2018982004 cites W2181876800 @default.
• W2018982004 cites W2410338837 @default.
• W2018982004 cites W2611993210 @default.
• W2018982004 doi "https://doi.org/10.1016/0014-4827(81)90402-x" @default.
• W2018982004 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/7447988" @default.
• W2018982004 hasPublicationYear "1981" @default.
• W2018982004 type Work @default.
• W2018982004 sameAs 2018982004 @default.
• W2018982004 citedByCount "16" @default.
• W2018982004 crossrefType "journal-article" @default.
• W2018982004 hasAuthorship W2018982004A5038629754 @default.
• W2018982004 hasAuthorship W2018982004A5072507966 @default.
• W2018982004 hasAuthorship W2018982004A5081383773 @default.
• W2018982004 hasConcept C1491633281 @default.
• W2018982004 hasConcept C153911025 @default.
• W2018982004 hasConcept C170493617 @default.
• W2018982004 hasConcept C175656101 @default.
• W2018982004 hasConcept C178790620 @default.
• W2018982004 hasConcept C181199279 @default.
• W2018982004 hasConcept C185592680 @default.
• W2018982004 hasConcept C25642318 @default.
• W2018982004 hasConcept C2778163477 @default.
• W2018982004 hasConcept C2778575167 @default.
• W2018982004 hasConcept C2778718757 @default.
• W2018982004 hasConcept C2778918659 @default.
• W2018982004 hasConcept C2780361610 @default.
• W2018982004 hasConcept C41625074 @default.
• W2018982004 hasConcept C553450214 @default.
• W2018982004 hasConcept C55493867 @default.
• W2018982004 hasConcept C84416704 @default.
• W2018982004 hasConcept C85789140 @default.
• W2018982004 hasConcept C86803240 @default.
• W2018982004 hasConceptScore W2018982004C1491633281 @default.
• W2018982004 hasConceptScore W2018982004C153911025 @default.
• W2018982004 hasConceptScore W2018982004C170493617 @default.
• W2018982004 hasConceptScore W2018982004C175656101 @default.
• W2018982004 hasConceptScore W2018982004C178790620 @default.
• W2018982004 hasConceptScore W2018982004C181199279 @default.
• W2018982004 hasConceptScore W2018982004C185592680 @default.
• W2018982004 hasConceptScore W2018982004C25642318 @default.
• W2018982004 hasConceptScore W2018982004C2778163477 @default.
• W2018982004 hasConceptScore W2018982004C2778575167 @default.
• W2018982004 hasConceptScore W2018982004C2778718757 @default.
• W2018982004 hasConceptScore W2018982004C2778918659 @default.
• W2018982004 hasConceptScore W2018982004C2780361610 @default.
• W2018982004 hasConceptScore W2018982004C41625074 @default.
• W2018982004 hasConceptScore W2018982004C553450214 @default.
• W2018982004 hasConceptScore W2018982004C55493867 @default.
• W2018982004 hasConceptScore W2018982004C84416704 @default.
• W2018982004 hasConceptScore W2018982004C85789140 @default.
• W2018982004 hasConceptScore W2018982004C86803240 @default.
• W2018982004 hasIssue "1" @default.
• W2018982004 hasLocation W20189820041 @default.
• W2018982004 hasLocation W20189820042 @default.
• W2018982004 hasOpenAccess W2018982004 @default.
• W2018982004 hasPrimaryLocation W20189820041 @default.
• W2018982004 hasRelatedWork W2002922162 @default.
• W2018982004 hasRelatedWork W2010640269 @default.
• W2018982004 hasRelatedWork W2011412660 @default.
• W2018982004 hasRelatedWork W2018982004 @default.
• W2018982004 hasRelatedWork W2073260302 @default.
• W2018982004 hasRelatedWork W2079593771 @default.
• W2018982004 hasRelatedWork W2308554016 @default.
• W2018982004 hasRelatedWork W2489612117 @default.
• W2018982004 hasRelatedWork W2764391888 @default.
• W2018982004 hasRelatedWork W82651922 @default.

• next