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• W2018982364 startingPage "367" @default.
• W2018982364 abstract "Human and simian immunodeficiency viruses (HIV and SIV, respectively) use chemokine receptors as coreceptors along with CD4 to mediate viral entry. Several orphan receptors, including GPR1, GPR15, and STRL33, can also serve as coreceptors for a more limited number of HIV and SIV isolates. We investigated whether these orphan receptors could function as efficient coreceptors for a diverse group of HIV and SIV envelopes (Envs) in comparison with the principal coreceptors CCR5 and CXCR4. We found that a limited number of HIV-1 isolates could mediate inefficient cell-cell fusion with the orphan receptors relative to CCR5 and CXCR4; however, none of the orphan receptors tested could support pseudotype virus infection despite robust infection via CCR5 or CXCR4. All except one of the SIV Envs tested mediated some degree of cell-cell fusion and pseudotype infection, with target cells expressing at least one of these orphan receptors, although CCR5 proved to be the most efficient coreceptor for infection. Only one SIV Env protein, BK28, could mediate infection using GPR1 as a coreceptor, albeit much less efficiently than with CCR5. In addition, use of these coreceptors did not correlate with the published tropism of the SIV clones and was strictly CD4 dependent for both SIV and HIV. We also examined the expression of these molecules in cell lines and primary cells widely used for virus propagation and as targets for infection. All cells examined expressed STRL33, a more limited number expressed GPR15, and GPR1 was much more restricted in its expression pattern. Taken together, our results indicate that GPR15 and STRL33 are rarely used by HIV-1 but are more frequently used by SIV strains, although not in a manner that correlates with SIV tropism." @default.
• W2018982364 created "2016-06-24" @default.
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• W2018982364 date "1998-09-01" @default.
• W2018982364 modified "2023-10-17" @default.
• W2018982364 title "Use of GPR1, GPR15, and STRL33 as Coreceptors by Diverse Human Immunodeficiency Virus Type 1 and Simian Immunodeficiency Virus Envelope Proteins" @default.
• W2018982364 cites W1481422886 @default.
• W2018982364 cites W1493470785 @default.
• W2018982364 cites W1494346716 @default.
• W2018982364 cites W1515616973 @default.
• W2018982364 cites W1563025779 @default.
• W2018982364 cites W1585442973 @default.
• W2018982364 cites W1595120220 @default.
• W2018982364 cites W1642524132 @default.
• W2018982364 cites W1657819831 @default.
• W2018982364 cites W1679721892 @default.
• W2018982364 cites W1726325960 @default.
• W2018982364 cites W1731073298 @default.
• W2018982364 cites W1840516913 @default.
• W2018982364 cites W1854844842 @default.
• W2018982364 cites W1900729316 @default.
• W2018982364 cites W1922162046 @default.
• W2018982364 cites W1963855922 @default.
• W2018982364 cites W1965019797 @default.
• W2018982364 cites W1973179589 @default.
• W2018982364 cites W1981440980 @default.
• W2018982364 cites W1981644527 @default.
• W2018982364 cites W1983466424 @default.
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• W2018982364 cites W2007021820 @default.
• W2018982364 cites W2008130406 @default.
• W2018982364 cites W2009324334 @default.
• W2018982364 cites W2011103103 @default.
• W2018982364 cites W2021932640 @default.
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• W2018982364 cites W2026444780 @default.
• W2018982364 cites W2029568430 @default.
• W2018982364 cites W2034430377 @default.
• W2018982364 cites W2041525705 @default.
• W2018982364 cites W2042578530 @default.
• W2018982364 cites W2067403399 @default.
• W2018982364 cites W2069407559 @default.
• W2018982364 cites W2071516463 @default.
• W2018982364 cites W2072901265 @default.
• W2018982364 cites W2075416959 @default.
• W2018982364 cites W2078778857 @default.
• W2018982364 cites W2080568374 @default.
• W2018982364 cites W2087003217 @default.
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• W2018982364 cites W2106513047 @default.
• W2018982364 cites W2116296362 @default.
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• W2018982364 cites W2126255146 @default.
• W2018982364 cites W2128135205 @default.
• W2018982364 cites W2129969146 @default.
• W2018982364 cites W2131350942 @default.
• W2018982364 cites W2131376910 @default.
• W2018982364 cites W2132142355 @default.
• W2018982364 cites W2137162710 @default.
• W2018982364 cites W2144172655 @default.
• W2018982364 cites W2152003330 @default.
• W2018982364 cites W2155989561 @default.
• W2018982364 cites W2156117117 @default.
• W2018982364 cites W2156694786 @default.
• W2018982364 cites W2163611230 @default.
• W2018982364 cites W2164592489 @default.
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• W2018982364 doi "https://doi.org/10.1006/viro.1998.9306" @default.
• W2018982364 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9791028" @default.
• W2018982364 hasPublicationYear "1998" @default.
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