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- W2018982854 abstract "Summary: Vibration perception thresholds (VPT) were measured using a new machine, the SMV-5 (Technolog Company, Tokyo, Japan) in 25 patients receiving maintenance haemodialysis without overt uraemic neuropathy. Patients who had other medical complications such as diabetes mellitus, dialysis amyloidosis or central nervous system dysfunction or peripheral vascular disease were excluded from this study. Forty per cent of the upper extremity VPT and 68% of the lower extremity VPT of the dialysis patients were abnormal, which was defined as greater than 2s.d. above the mean of the normal subjects. the VPT of smokers (n= 7) were significantly higher than those of non-smokers (n= 18; P<0.01). the VPT of the patients in the treated group (n= 13, including 4 smokers) improved 6 months following the initiation of methylcobalamin therapy (P<0.05). the high incidence of subclinical uraemic neuropathy led us to consider that uraemic neuropathy should be detected at an early stage. the relationship between neurologic disorders and smoking, and the efficacy of methyl cobalamin (analogue vitamin B12) in the treatment oraemic neuropathy (and in the peripheral neuropathy noted in Leber's disease) suggest that cyanide may be the uraemic toxin responsible for the neuropathy. Further studies of chronic cyanide exposure and the metabolism of cyanide in patients with uraemia are necessary." @default.
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- W2018982854 date "1996-02-01" @default.
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- W2018982854 title "Efficacy of methylcobalamin in subclinical uraemic neuropathy as detected by measuring vibration perception thresholds" @default.
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- W2018982854 doi "https://doi.org/10.1111/j.1440-1797.1996.tb00062.x" @default.
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