Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018983257> ?p ?o ?g. }
- W2018983257 endingPage "31" @default.
- W2018983257 startingPage "27" @default.
- W2018983257 abstract "The effects of apomorphine and the putative dopamine autoreceptor agonist, CGS 15855A, were evaluated in several functional assays that are modulated by pre- or post-synaptic D2 receptors. These included release of prolactin in vivo and in vitro from cultured lactotrophs; levels of dihydroxyphenylacetic acid (DOPAC) in the striatum; levels of acetylcholine (ACh); in the striatum and concentrations of cyclic guanosine monophosphate (cyclic GMP) in the cerebellum. The secretion of prolactin was inhibited by CGS 15855A in vitro and in vivo and which also decreased the levels of DOPAC in the striatum at doses 5-25 times less than those required to increase ACh in the striatum and levels of cGMP in the cerebellum. In contrast, apomorphine possessed a dose-ratio between 1.5 and 8.6 for these assay systems. These data suggest that CGS 15855A is a selective dopamine autoreceptor agonist which preferentially stimulates D2 receptors on lactotrophs and dopaminergic neurons as compared to D2 receptors on cholinergic interneurons in the striatum." @default.
- W2018983257 created "2016-06-24" @default.
- W2018983257 creator A5021691550 @default.
- W2018983257 creator A5023640237 @default.
- W2018983257 creator A5028263102 @default.
- W2018983257 creator A5030594914 @default.
- W2018983257 creator A5031219597 @default.
- W2018983257 creator A5047627163 @default.
- W2018983257 date "1989-01-01" @default.
- W2018983257 modified "2023-09-25" @default.
- W2018983257 title "The dopamine autoreceptor agonist, (±)-Trans-1,3,4,4a5, 10b-hexahydro-4-propyl-2h [1]benzopyrano [3,4-b] pyridin-9-ol hydrochloride (CGS 15855A), modulates striatal dopamine metabolism and prolactin release" @default.
- W2018983257 cites W134625458 @default.
- W2018983257 cites W1848069441 @default.
- W2018983257 cites W1963960260 @default.
- W2018983257 cites W1964345818 @default.
- W2018983257 cites W1979034983 @default.
- W2018983257 cites W1981603764 @default.
- W2018983257 cites W1986039293 @default.
- W2018983257 cites W1989314580 @default.
- W2018983257 cites W1989531026 @default.
- W2018983257 cites W1995063924 @default.
- W2018983257 cites W2003673385 @default.
- W2018983257 cites W2004156074 @default.
- W2018983257 cites W2010628499 @default.
- W2018983257 cites W2010875011 @default.
- W2018983257 cites W2013417531 @default.
- W2018983257 cites W2015723254 @default.
- W2018983257 cites W2021357904 @default.
- W2018983257 cites W2024994836 @default.
- W2018983257 cites W2025433728 @default.
- W2018983257 cites W2029520736 @default.
- W2018983257 cites W2032179760 @default.
- W2018983257 cites W2035188344 @default.
- W2018983257 cites W2036374082 @default.
- W2018983257 cites W2042206188 @default.
- W2018983257 cites W2059765301 @default.
- W2018983257 cites W2062080834 @default.
- W2018983257 cites W2064005438 @default.
- W2018983257 cites W2067363410 @default.
- W2018983257 cites W2067677077 @default.
- W2018983257 cites W2068380010 @default.
- W2018983257 cites W2069194714 @default.
- W2018983257 cites W2074556443 @default.
- W2018983257 cites W2099793114 @default.
- W2018983257 cites W2135519495 @default.
- W2018983257 cites W2138446656 @default.
- W2018983257 cites W2319024719 @default.
- W2018983257 cites W2320291967 @default.
- W2018983257 cites W2347664689 @default.
- W2018983257 cites W2407544719 @default.
- W2018983257 cites W1984001035 @default.
- W2018983257 doi "https://doi.org/10.1016/0028-3908(89)90063-4" @default.
- W2018983257 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2522597" @default.
- W2018983257 hasPublicationYear "1989" @default.
- W2018983257 type Work @default.
- W2018983257 sameAs 2018983257 @default.
- W2018983257 citedByCount "2" @default.
- W2018983257 crossrefType "journal-article" @default.
- W2018983257 hasAuthorship W2018983257A5021691550 @default.
- W2018983257 hasAuthorship W2018983257A5023640237 @default.
- W2018983257 hasAuthorship W2018983257A5028263102 @default.
- W2018983257 hasAuthorship W2018983257A5030594914 @default.
- W2018983257 hasAuthorship W2018983257A5031219597 @default.
- W2018983257 hasAuthorship W2018983257A5047627163 @default.
- W2018983257 hasConcept C120069818 @default.
- W2018983257 hasConcept C126322002 @default.
- W2018983257 hasConcept C134018914 @default.
- W2018983257 hasConcept C137183658 @default.
- W2018983257 hasConcept C170493617 @default.
- W2018983257 hasConcept C185592680 @default.
- W2018983257 hasConcept C2777525119 @default.
- W2018983257 hasConcept C2778938600 @default.
- W2018983257 hasConcept C2779064019 @default.
- W2018983257 hasConcept C2780062018 @default.
- W2018983257 hasConcept C44208683 @default.
- W2018983257 hasConcept C513476851 @default.
- W2018983257 hasConcept C54799321 @default.
- W2018983257 hasConcept C55493867 @default.
- W2018983257 hasConcept C71315377 @default.
- W2018983257 hasConcept C71924100 @default.
- W2018983257 hasConcept C8439214 @default.
- W2018983257 hasConcept C86803240 @default.
- W2018983257 hasConceptScore W2018983257C120069818 @default.
- W2018983257 hasConceptScore W2018983257C126322002 @default.
- W2018983257 hasConceptScore W2018983257C134018914 @default.
- W2018983257 hasConceptScore W2018983257C137183658 @default.
- W2018983257 hasConceptScore W2018983257C170493617 @default.
- W2018983257 hasConceptScore W2018983257C185592680 @default.
- W2018983257 hasConceptScore W2018983257C2777525119 @default.
- W2018983257 hasConceptScore W2018983257C2778938600 @default.
- W2018983257 hasConceptScore W2018983257C2779064019 @default.
- W2018983257 hasConceptScore W2018983257C2780062018 @default.
- W2018983257 hasConceptScore W2018983257C44208683 @default.
- W2018983257 hasConceptScore W2018983257C513476851 @default.
- W2018983257 hasConceptScore W2018983257C54799321 @default.
- W2018983257 hasConceptScore W2018983257C55493867 @default.
- W2018983257 hasConceptScore W2018983257C71315377 @default.
- W2018983257 hasConceptScore W2018983257C71924100 @default.