FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018983670> ?p ?o ?g. }

• W2018983670 endingPage "507" @default.
• W2018983670 startingPage "497" @default.
• W2018983670 abstract "Intra- and intercellular communication in or between cells allows adaptation to changes in the environment. Formation of reactive oxygen (ROS) and nitrogen (RNS) species in response to external insults gained considerable attention in provoking cell demise along an apoptotic subroute of cell death, thus attributing radical formation to pathologies. In close association, stabilization of the tumor suppressor p53 and activation of caspases convey proapoptotic signaling. Complexity was added with the notion that ROS and RNS signals overlap and/or produce synergistic as well as antagonistic effects. With respect to nitric oxide (NO) signaling, it became clear that the molecule is endowed with pro- or antiapoptotic signaling capabilities, depending to some extend on the concentration and cellular context, i.e., ROS generation. Here, some established concepts are summarized that allow an explanation of p53 accumulation under the impact of NO and an understanding of NO-evoked cell protection at the level of caspase inhibition, cyclic GMP formation, or expression of antiapoptotic proteins. In addition, the overlapping sphere of ROS and RNS signaling is recapitulated to appreciate cell physiology/pathology with the notion that marginal changes in the flux rates of either NO or superoxide may shift vital signals used for communication and cell survival into areas of pathology in close association with apoptosis/necrosis.Antioxid. Redox Signal. 7, 497–507." @default.
• W2018983670 created "2016-06-24" @default.
• W2018983670 creator A5056936426 @default.
• W2018983670 date "2005-03-01" @default.
• W2018983670 modified "2023-10-16" @default.
• W2018983670 title "The Intimate Relation Between Nitric Oxide and Superoxide in Apoptosis and Cell Survival" @default.
• W2018983670 cites W1269597682 @default.
• W2018983670 cites W1482300775 @default.
• W2018983670 cites W1489860413 @default.
• W2018983670 cites W1492597659 @default.
• W2018983670 cites W1515506492 @default.
• W2018983670 cites W1535480790 @default.
• W2018983670 cites W1571529930 @default.
• W2018983670 cites W1604468403 @default.
• W2018983670 cites W1644794975 @default.
• W2018983670 cites W1657916452 @default.
• W2018983670 cites W1745634660 @default.
• W2018983670 cites W1963732685 @default.
• W2018983670 cites W1963877328 @default.
• W2018983670 cites W1965699162 @default.
• W2018983670 cites W1966560941 @default.
• W2018983670 cites W1972528195 @default.
• W2018983670 cites W1973138891 @default.
• W2018983670 cites W1973368080 @default.
• W2018983670 cites W1975597097 @default.
• W2018983670 cites W1975654814 @default.
• W2018983670 cites W1978220492 @default.
• W2018983670 cites W1978503888 @default.
• W2018983670 cites W1978549014 @default.
• W2018983670 cites W1979724073 @default.
• W2018983670 cites W1983587113 @default.
• W2018983670 cites W1983648009 @default.
• W2018983670 cites W1983816549 @default.
• W2018983670 cites W1985247067 @default.
• W2018983670 cites W1985877433 @default.
• W2018983670 cites W1987576919 @default.
• W2018983670 cites W1990767395 @default.
• W2018983670 cites W1992981111 @default.
• W2018983670 cites W1995166501 @default.
• W2018983670 cites W2002064752 @default.
• W2018983670 cites W2004612309 @default.
• W2018983670 cites W2004658589 @default.
• W2018983670 cites W2009601307 @default.
• W2018983670 cites W2009922466 @default.
• W2018983670 cites W2011342890 @default.
• W2018983670 cites W2012451275 @default.
• W2018983670 cites W2017798605 @default.
• W2018983670 cites W2018073322 @default.
• W2018983670 cites W2020736600 @default.
• W2018983670 cites W2022699060 @default.
• W2018983670 cites W2024758557 @default.
• W2018983670 cites W2025174746 @default.
• W2018983670 cites W2026085787 @default.
• W2018983670 cites W2034946903 @default.
• W2018983670 cites W2037159578 @default.
• W2018983670 cites W2041235361 @default.
• W2018983670 cites W2047837391 @default.
• W2018983670 cites W2050447841 @default.
• W2018983670 cites W2055256941 @default.
• W2018983670 cites W2056009784 @default.
• W2018983670 cites W2056418403 @default.
• W2018983670 cites W2060925403 @default.
• W2018983670 cites W2062445457 @default.
• W2018983670 cites W2062753450 @default.
• W2018983670 cites W2062757512 @default.
• W2018983670 cites W2063205344 @default.
• W2018983670 cites W2070243129 @default.
• W2018983670 cites W2071564970 @default.
• W2018983670 cites W2072282073 @default.
• W2018983670 cites W2077868837 @default.
• W2018983670 cites W2080633084 @default.
• W2018983670 cites W2081558365 @default.
• W2018983670 cites W2081843959 @default.
• W2018983670 cites W2083855141 @default.
• W2018983670 cites W2085936016 @default.
• W2018983670 cites W2086485923 @default.
• W2018983670 cites W2086908238 @default.
• W2018983670 cites W2088363137 @default.
• W2018983670 cites W2089924484 @default.
• W2018983670 cites W2090762348 @default.
• W2018983670 cites W2091833651 @default.
• W2018983670 cites W2093847882 @default.
• W2018983670 cites W2097369125 @default.
• W2018983670 cites W2098606880 @default.
• W2018983670 cites W2098935972 @default.
• W2018983670 cites W2101430535 @default.
• W2018983670 cites W2102909249 @default.
• W2018983670 cites W2103230358 @default.
• W2018983670 cites W2107789276 @default.
• W2018983670 cites W2113120391 @default.
• W2018983670 cites W2115410765 @default.
• W2018983670 cites W2118411078 @default.
• W2018983670 cites W2118440238 @default.
• W2018983670 cites W2119796215 @default.
• W2018983670 cites W2124748247 @default.
• W2018983670 cites W2127113978 @default.
• W2018983670 cites W2127226332 @default.
• W2018983670 cites W2135109846 @default.

• next