FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018984947> ?p ?o ?g. }

• W2018984947 endingPage "754" @default.
• W2018984947 startingPage "750" @default.
• W2018984947 abstract "Alterations of gene expression in squamous cell carcinoma (SCC) cell lines derived from the larynx and keratinocytes derived from adjacent normal mucosa of the larynx have been studied using the mRNA differential display technique. Lane-to-lane comparison of reverse transcribed mRNA showed a strong repression of a 148 bp fragment in SCC cells. The fragment was reamplified and cloned. Sequencing revealed a 99.3% homology with a region in exon 17 of the human galactocerebrosidase (GALC) gene. Northern blot analysis confirmed the differential expression of this gene in both carcinoma cell lines and laryngeal SCC biopsies in contrast with corresponding normal mucosa. To provide further evidence for the differential expression rate, both types of cells were transiently transfected with a 152 bp (-176 to -24) high regulatory promoter element of the 5' flanking region of the GALC gene. Results of 3 independent transfection experiments indicated a 16-fold repression of the GALC gene expression in SCC cells compared with benign keratinocytes. However, neither mutation nor other alterations of the promoter sequence were detected. Expression of the GALC gene is thus greatly affected in SCCs of the larynx." @default.
• W2018984947 created "2016-06-24" @default.
• W2018984947 creator A5000215779 @default.
• W2018984947 creator A5000462527 @default.
• W2018984947 creator A5016885020 @default.
• W2018984947 creator A5036412214 @default.
• W2018984947 creator A5037920495 @default.
• W2018984947 creator A5038688535 @default.
• W2018984947 creator A5054854359 @default.
• W2018984947 creator A5062588593 @default.
• W2018984947 creator A5068022679 @default.
• W2018984947 creator A5072459881 @default.
• W2018984947 creator A5075990232 @default.
• W2018984947 creator A5085924567 @default.
• W2018984947 creator A5091059192 @default.
• W2018984947 date "1999-12-10" @default.
• W2018984947 modified "2023-10-09" @default.
• W2018984947 title "Transcriptional repression of the human galactocerebrosidase gene in squamous cell carcinomas of the larynx" @default.
• W2018984947 cites W1963573390 @default.
• W2018984947 cites W1979664955 @default.
• W2018984947 cites W1980065068 @default.
• W2018984947 cites W1994595003 @default.
• W2018984947 cites W2024657139 @default.
• W2018984947 cites W2028781651 @default.
• W2018984947 cites W2036092831 @default.
• W2018984947 cites W2051035436 @default.
• W2018984947 cites W2051039732 @default.
• W2018984947 cites W2077808648 @default.
• W2018984947 cites W2082258298 @default.
• W2018984947 cites W2090685643 @default.
• W2018984947 cites W2092023230 @default.
• W2018984947 cites W2114992270 @default.
• W2018984947 cites W2130111557 @default.
• W2018984947 cites W2153909503 @default.
• W2018984947 cites W2156873390 @default.
• W2018984947 cites W2175766170 @default.
• W2018984947 cites W2478060819 @default.
• W2018984947 cites W4293247451 @default.
• W2018984947 doi "https://doi.org/10.1002/(sici)1097-0215(19991210)83:6<750::aid-ijc9>3.0.co;2-v" @default.
• W2018984947 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10597190" @default.
• W2018984947 hasPublicationYear "1999" @default.
• W2018984947 type Work @default.
• W2018984947 sameAs 2018984947 @default.
• W2018984947 citedByCount "8" @default.
• W2018984947 countsByYear W20189849472015 @default.
• W2018984947 countsByYear W20189849472016 @default.
• W2018984947 countsByYear W20189849472022 @default.
• W2018984947 countsByYear W20189849472023 @default.
• W2018984947 crossrefType "journal-article" @default.
• W2018984947 hasAuthorship W2018984947A5000215779 @default.
• W2018984947 hasAuthorship W2018984947A5000462527 @default.
• W2018984947 hasAuthorship W2018984947A5016885020 @default.
• W2018984947 hasAuthorship W2018984947A5036412214 @default.
• W2018984947 hasAuthorship W2018984947A5037920495 @default.
• W2018984947 hasAuthorship W2018984947A5038688535 @default.
• W2018984947 hasAuthorship W2018984947A5054854359 @default.
• W2018984947 hasAuthorship W2018984947A5062588593 @default.
• W2018984947 hasAuthorship W2018984947A5068022679 @default.
• W2018984947 hasAuthorship W2018984947A5072459881 @default.
• W2018984947 hasAuthorship W2018984947A5075990232 @default.
• W2018984947 hasAuthorship W2018984947A5085924567 @default.
• W2018984947 hasAuthorship W2018984947A5091059192 @default.
• W2018984947 hasConcept C104317684 @default.
• W2018984947 hasConcept C150194340 @default.
• W2018984947 hasConcept C153911025 @default.
• W2018984947 hasConcept C177707886 @default.
• W2018984947 hasConcept C186310378 @default.
• W2018984947 hasConcept C2776657240 @default.
• W2018984947 hasConcept C2777546739 @default.
• W2018984947 hasConcept C29906990 @default.
• W2018984947 hasConcept C2994460389 @default.
• W2018984947 hasConcept C36823959 @default.
• W2018984947 hasConcept C54009773 @default.
• W2018984947 hasConcept C54355233 @default.
• W2018984947 hasConcept C81885089 @default.
• W2018984947 hasConcept C86803240 @default.
• W2018984947 hasConceptScore W2018984947C104317684 @default.
• W2018984947 hasConceptScore W2018984947C150194340 @default.
• W2018984947 hasConceptScore W2018984947C153911025 @default.
• W2018984947 hasConceptScore W2018984947C177707886 @default.
• W2018984947 hasConceptScore W2018984947C186310378 @default.
• W2018984947 hasConceptScore W2018984947C2776657240 @default.
• W2018984947 hasConceptScore W2018984947C2777546739 @default.
• W2018984947 hasConceptScore W2018984947C29906990 @default.
• W2018984947 hasConceptScore W2018984947C2994460389 @default.
• W2018984947 hasConceptScore W2018984947C36823959 @default.
• W2018984947 hasConceptScore W2018984947C54009773 @default.
• W2018984947 hasConceptScore W2018984947C54355233 @default.
• W2018984947 hasConceptScore W2018984947C81885089 @default.
• W2018984947 hasConceptScore W2018984947C86803240 @default.
• W2018984947 hasIssue "6" @default.
• W2018984947 hasLocation W20189849471 @default.
• W2018984947 hasLocation W20189849472 @default.
• W2018984947 hasOpenAccess W2018984947 @default.
• W2018984947 hasPrimaryLocation W20189849471 @default.
• W2018984947 hasRelatedWork W1792262194 @default.
• W2018984947 hasRelatedWork W1998686924 @default.
• W2018984947 hasRelatedWork W2007283874 @default.

• next