Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018985332> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2018985332 endingPage "1796" @default.
- W2018985332 startingPage "1788" @default.
- W2018985332 abstract "In order to study the contribution of extrahepatic C6 to anti-Thy1.1 nephritis, C6 deficient PVG/c- livers were grafted in C6 sufficient PVG/c+ rats (Tx-L). Infusion of anti-Thy1.1 antibodies in Tx-L and PVG/c+ rats resulted in generation of C5b-9 complexes and subsequent glomerular injury, while infusion of anti-Thy1.1 antibodies in PVG/c- rats revealed no detectable C6 deposition. Because C6 mRNA was expressed in both liver and kidney tissue of PVG/c+ rats, we assessed whether production of C6 in the kidney alone was sufficient for glomerular injury. One kidney of a PVG/c- rat was replaced with a PVG/c+ kidney (Tx + K) followed by administration of anti-Thy1.1 antibodies. C6 deposits were detectable neither in PVG/c+ kidneys nor in PVG/c- kidneys of Tx + K rats, indicating that C6 production in PVG/c+ kidneys alone is not sufficient to contribute to renal injury. That C6 production had occurred was suggested by the presence of equal amounts C6 mRNA in control PVG/c+ kidneys and in grafted PVG/c+ kidneys of Tx + K rats. C6 mRNA expression in kidney tissue of PVG/c+ rats is presumably derived from peritubular sites. In conclusion, we have demonstrated that extrahepatic, but not renal synthesis of, C6 is sufficient to contribute to glomerular injury during anti-Thy1.1 nephritis." @default.
- W2018985332 created "2016-06-24" @default.
- W2018985332 creator A5003903620 @default.
- W2018985332 creator A5004758671 @default.
- W2018985332 creator A5032969809 @default.
- W2018985332 creator A5046232552 @default.
- W2018985332 creator A5050301613 @default.
- W2018985332 creator A5060480065 @default.
- W2018985332 creator A5087987213 @default.
- W2018985332 date "1997-06-01" @default.
- W2018985332 modified "2023-10-18" @default.
- W2018985332 title "Extrahepatic C6 is as effective as hepatic C6 in the generation of renal C5b-9 complexes" @default.
- W2018985332 cites W1965402789 @default.
- W2018985332 cites W1969294718 @default.
- W2018985332 cites W1982707536 @default.
- W2018985332 cites W1983588293 @default.
- W2018985332 cites W1989094022 @default.
- W2018985332 cites W1989841062 @default.
- W2018985332 cites W1990372621 @default.
- W2018985332 cites W1990960985 @default.
- W2018985332 cites W1993459259 @default.
- W2018985332 cites W2003590292 @default.
- W2018985332 cites W2014669590 @default.
- W2018985332 cites W2017344315 @default.
- W2018985332 cites W2025123467 @default.
- W2018985332 cites W2028856801 @default.
- W2018985332 cites W2040708401 @default.
- W2018985332 cites W2045904371 @default.
- W2018985332 cites W2048681283 @default.
- W2018985332 cites W2052765919 @default.
- W2018985332 cites W2092247393 @default.
- W2018985332 cites W2092602709 @default.
- W2018985332 cites W2092918048 @default.
- W2018985332 cites W2095953710 @default.
- W2018985332 cites W2099871715 @default.
- W2018985332 cites W2138404517 @default.
- W2018985332 cites W2139370490 @default.
- W2018985332 cites W2148767303 @default.
- W2018985332 doi "https://doi.org/10.1038/ki.1997.246" @default.
- W2018985332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9186868" @default.
- W2018985332 hasPublicationYear "1997" @default.
- W2018985332 type Work @default.
- W2018985332 sameAs 2018985332 @default.
- W2018985332 citedByCount "14" @default.
- W2018985332 countsByYear W20189853322022 @default.
- W2018985332 crossrefType "journal-article" @default.
- W2018985332 hasAuthorship W2018985332A5003903620 @default.
- W2018985332 hasAuthorship W2018985332A5004758671 @default.
- W2018985332 hasAuthorship W2018985332A5032969809 @default.
- W2018985332 hasAuthorship W2018985332A5046232552 @default.
- W2018985332 hasAuthorship W2018985332A5050301613 @default.
- W2018985332 hasAuthorship W2018985332A5060480065 @default.
- W2018985332 hasAuthorship W2018985332A5087987213 @default.
- W2018985332 hasBestOaLocation W20189853321 @default.
- W2018985332 hasConcept C104317684 @default.
- W2018985332 hasConcept C105580179 @default.
- W2018985332 hasConcept C126322002 @default.
- W2018985332 hasConcept C134018914 @default.
- W2018985332 hasConcept C159654299 @default.
- W2018985332 hasConcept C185592680 @default.
- W2018985332 hasConcept C203014093 @default.
- W2018985332 hasConcept C2777058396 @default.
- W2018985332 hasConcept C2780091579 @default.
- W2018985332 hasConcept C2780829873 @default.
- W2018985332 hasConcept C55493867 @default.
- W2018985332 hasConcept C71924100 @default.
- W2018985332 hasConceptScore W2018985332C104317684 @default.
- W2018985332 hasConceptScore W2018985332C105580179 @default.
- W2018985332 hasConceptScore W2018985332C126322002 @default.
- W2018985332 hasConceptScore W2018985332C134018914 @default.
- W2018985332 hasConceptScore W2018985332C159654299 @default.
- W2018985332 hasConceptScore W2018985332C185592680 @default.
- W2018985332 hasConceptScore W2018985332C203014093 @default.
- W2018985332 hasConceptScore W2018985332C2777058396 @default.
- W2018985332 hasConceptScore W2018985332C2780091579 @default.
- W2018985332 hasConceptScore W2018985332C2780829873 @default.
- W2018985332 hasConceptScore W2018985332C55493867 @default.
- W2018985332 hasConceptScore W2018985332C71924100 @default.
- W2018985332 hasIssue "6" @default.
- W2018985332 hasLocation W20189853321 @default.
- W2018985332 hasLocation W20189853322 @default.
- W2018985332 hasOpenAccess W2018985332 @default.
- W2018985332 hasPrimaryLocation W20189853321 @default.
- W2018985332 hasRelatedWork W2079481850 @default.
- W2018985332 hasRelatedWork W2113016301 @default.
- W2018985332 hasRelatedWork W2140972898 @default.
- W2018985332 hasRelatedWork W2144507234 @default.
- W2018985332 hasRelatedWork W2278268574 @default.
- W2018985332 hasRelatedWork W2330509958 @default.
- W2018985332 hasRelatedWork W2622410745 @default.
- W2018985332 hasRelatedWork W3203346794 @default.
- W2018985332 hasRelatedWork W3217440945 @default.
- W2018985332 hasRelatedWork W4220672163 @default.
- W2018985332 hasVolume "51" @default.
- W2018985332 isParatext "false" @default.
- W2018985332 isRetracted "false" @default.
- W2018985332 magId "2018985332" @default.
- W2018985332 workType "article" @default.