FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018985514> ?p ?o ?g. }

• W2018985514 endingPage "359" @default.
• W2018985514 startingPage "352" @default.
• W2018985514 abstract "Lipocalins tailored with high affinity for prescribed ligands, so-called anticalins, constitute promising candidates as antidotes. Here, we present an animal study to investigate both pharmacokinetic and clinical effects of an anticalin specific for the digitalis compound digoxin. Intravenous digoxin (2.5–50 μg/kg/min) was administered to rats until first changes in the ECG occurred (dose finding study) or a priori for 30 min (kinetic study). The anticalin DigA16(H86N), dubbed DigiCal, was administered intravenously at absolute doses of 1, 5, 10 and 20 mg, while the control group received isotonic saline. Hemodynamic changes, several ECG parameters and digoxin concentration in plasma were monitored at given time intervals. After DigiCal administration free digoxin concentration in plasma ultrafiltrate declined dramatically within 1 min to the presumably non-toxic range. There was also a significant and DigiCal dose-dependent effect on longer survival, less ECG alterations, arrhythmia, and improved hemodynamics. Infusion of a lower digoxin dose (2.5 μg/kg/min) resulted in a more sustained reduction of free digoxin in plasma after DigiCal administration compared to a higher digoxin dose (25 μg/kg/min), whereas ECG and hemodynamic parameters did not markedly differ, reflecting the known relative insensitivity of rats towards digoxin toxicity. Notably, we observed a re-increase of free digoxin in plasma some time after bolus administration of DigiCal, which was presumably due to toxin redistribution from tissue in combination with the relatively fast renal clearance of the rather small protein antidote. We conclude that anticalins with appropriately engineered drug-binding activities and, possibly, prolonged plasma half-life offer prospects for next-generation antidotal therapy." @default.
• W2018985514 created "2016-06-24" @default.
• W2018985514 creator A5007011101 @default.
• W2018985514 creator A5025735412 @default.
• W2018985514 creator A5042650474 @default.
• W2018985514 creator A5046936730 @default.
• W2018985514 creator A5051796358 @default.
• W2018985514 creator A5070530041 @default.
• W2018985514 creator A5071832042 @default.
• W2018985514 creator A5072468811 @default.
• W2018985514 creator A5082392902 @default.
• W2018985514 date "2012-09-01" @default.
• W2018985514 modified "2023-09-28" @default.
• W2018985514 title "Intravenous application of an anticalin dramatically lowers plasma digoxin levels and reduces its toxic effects in rats" @default.
• W2018985514 cites W1515657892 @default.
• W2018985514 cites W1922065206 @default.
• W2018985514 cites W1979897300 @default.
• W2018985514 cites W1992371538 @default.
• W2018985514 cites W1996907597 @default.
• W2018985514 cites W2008436776 @default.
• W2018985514 cites W2008935666 @default.
• W2018985514 cites W2011427357 @default.
• W2018985514 cites W2014027961 @default.
• W2018985514 cites W2023535884 @default.
• W2018985514 cites W2029015537 @default.
• W2018985514 cites W2029094516 @default.
• W2018985514 cites W2033660436 @default.
• W2018985514 cites W2036124167 @default.
• W2018985514 cites W2037275316 @default.
• W2018985514 cites W2048328674 @default.
• W2018985514 cites W2054417332 @default.
• W2018985514 cites W2062229995 @default.
• W2018985514 cites W2067779211 @default.
• W2018985514 cites W2068028691 @default.
• W2018985514 cites W2069110655 @default.
• W2018985514 cites W2070148650 @default.
• W2018985514 cites W2078896733 @default.
• W2018985514 cites W2086889737 @default.
• W2018985514 cites W2088362721 @default.
• W2018985514 cites W2089282467 @default.
• W2018985514 cites W2089966720 @default.
• W2018985514 cites W2094375186 @default.
• W2018985514 cites W2106433536 @default.
• W2018985514 cites W2113349269 @default.
• W2018985514 cites W2127630336 @default.
• W2018985514 cites W2136008324 @default.
• W2018985514 cites W2144434237 @default.
• W2018985514 cites W2147810684 @default.
• W2018985514 cites W2150231354 @default.
• W2018985514 cites W2151702380 @default.
• W2018985514 cites W2157181809 @default.
• W2018985514 cites W2252438312 @default.
• W2018985514 cites W2301202054 @default.
• W2018985514 cites W2320620955 @default.
• W2018985514 cites W4299577574 @default.
• W2018985514 doi "https://doi.org/10.1016/j.taap.2012.07.009" @default.
• W2018985514 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22820422" @default.
• W2018985514 hasPublicationYear "2012" @default.
• W2018985514 type Work @default.
• W2018985514 sameAs 2018985514 @default.
• W2018985514 citedByCount "19" @default.
• W2018985514 countsByYear W20189855142013 @default.
• W2018985514 countsByYear W20189855142014 @default.
• W2018985514 countsByYear W20189855142015 @default.
• W2018985514 countsByYear W20189855142016 @default.
• W2018985514 countsByYear W20189855142017 @default.
• W2018985514 countsByYear W20189855142018 @default.
• W2018985514 countsByYear W20189855142019 @default.
• W2018985514 countsByYear W20189855142020 @default.
• W2018985514 countsByYear W20189855142021 @default.
• W2018985514 countsByYear W20189855142023 @default.
• W2018985514 crossrefType "journal-article" @default.
• W2018985514 hasAuthorship W2018985514A5007011101 @default.
• W2018985514 hasAuthorship W2018985514A5025735412 @default.
• W2018985514 hasAuthorship W2018985514A5042650474 @default.
• W2018985514 hasAuthorship W2018985514A5046936730 @default.
• W2018985514 hasAuthorship W2018985514A5051796358 @default.
• W2018985514 hasAuthorship W2018985514A5070530041 @default.
• W2018985514 hasAuthorship W2018985514A5071832042 @default.
• W2018985514 hasAuthorship W2018985514A5072468811 @default.
• W2018985514 hasAuthorship W2018985514A5082392902 @default.
• W2018985514 hasConcept C112705442 @default.
• W2018985514 hasConcept C126322002 @default.
• W2018985514 hasConcept C178853913 @default.
• W2018985514 hasConcept C185592680 @default.
• W2018985514 hasConcept C2776445394 @default.
• W2018985514 hasConcept C2777397205 @default.
• W2018985514 hasConcept C2777707475 @default.
• W2018985514 hasConcept C2778198053 @default.
• W2018985514 hasConcept C2779365888 @default.
• W2018985514 hasConcept C29730261 @default.
• W2018985514 hasConcept C43376680 @default.
• W2018985514 hasConcept C71924100 @default.
• W2018985514 hasConcept C98274493 @default.
• W2018985514 hasConceptScore W2018985514C112705442 @default.
• W2018985514 hasConceptScore W2018985514C126322002 @default.
• W2018985514 hasConceptScore W2018985514C178853913 @default.
• W2018985514 hasConceptScore W2018985514C185592680 @default.

• next