FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018995079> ?p ?o ?g. }

• W2018995079 endingPage "23073" @default.
• W2018995079 startingPage "23059" @default.
• W2018995079 abstract "This study was designed to investigate the regulatory role of l-cystathionine in human macrophage apoptosis induced by oxidized low density lipoprotein (ox-LDL) and its possible mechanisms. THP-1 cells were induced with phorbol 12-myristate 13-acetate (PMA) and differentiated into macrophages. Macrophages were incubated with ox-LDL after pretreatment with l-cystathionine. Superoxide anion, apoptosis, mitochondrial membrane potential, and mitochondrial permeability transition pore (MPTP) opening were examined. Caspase-9 activities and expression of cleaved caspase-3 were measured. The results showed that compared with control group, ox-LDL treatment significantly promoted superoxide anion generation, release of cytochrome c (cytc) from mitochondrion into cytoplasm, caspase-9 activities, cleavage of caspase-3, and cell apoptosis, in addition to reduced mitochondrial membrane potential as well as increased MPTP opening. However, 0.3 and 1.0 mmol/L l-cystathionine significantly reduced superoxide anion generation, increased mitochondrial membrane potential, and markedly decreased MPTP opening in ox-LDL + l-cystathionine macrophages. Moreover, compared to ox-LDL treated-cells, release of cytc from mitochondrion into cytoplasm, caspase-9 activities, cleavage of caspase-3, and apoptosis levels in l-cystathionine pretreated cells were profoundly attenuated. Taken together, our results suggested that l-cystathionine could antagonize mitochondria-mediated human macrophage apoptosis induced by ox-LDL via inhibition of cytc release and caspase activation." @default.
• W2018995079 created "2016-06-24" @default.
• W2018995079 creator A5000401545 @default.
• W2018995079 creator A5003595535 @default.
• W2018995079 creator A5011807899 @default.
• W2018995079 creator A5027083112 @default.
• W2018995079 creator A5056084869 @default.
• W2018995079 creator A5067952676 @default.
• W2018995079 creator A5075653086 @default.
• W2018995079 creator A5080248487 @default.
• W2018995079 creator A5085140875 @default.
• W2018995079 date "2014-12-11" @default.
• W2018995079 modified "2023-10-13" @default.
• W2018995079 title "l-Cystathionine Inhibits the Mitochondria-Mediated Macrophage Apoptosis Induced by Oxidized Low Density Lipoprotein" @default.
• W2018995079 cites W1560222544 @default.
• W2018995079 cites W1685518911 @default.
• W2018995079 cites W1888102200 @default.
• W2018995079 cites W1966845084 @default.
• W2018995079 cites W1967760829 @default.
• W2018995079 cites W1968801561 @default.
• W2018995079 cites W1982224124 @default.
• W2018995079 cites W1988219643 @default.
• W2018995079 cites W1988817734 @default.
• W2018995079 cites W1996433471 @default.
• W2018995079 cites W1998454517 @default.
• W2018995079 cites W2000529161 @default.
• W2018995079 cites W2002138887 @default.
• W2018995079 cites W2004644030 @default.
• W2018995079 cites W2005861034 @default.
• W2018995079 cites W2010442697 @default.
• W2018995079 cites W2027328852 @default.
• W2018995079 cites W2027966439 @default.
• W2018995079 cites W2028288720 @default.
• W2018995079 cites W2030967970 @default.
• W2018995079 cites W2065359879 @default.
• W2018995079 cites W2078782232 @default.
• W2018995079 cites W2081427932 @default.
• W2018995079 cites W2114651939 @default.
• W2018995079 cites W2115457290 @default.
• W2018995079 cites W2119683782 @default.
• W2018995079 cites W2121638241 @default.
• W2018995079 cites W2129256971 @default.
• W2018995079 cites W2135044142 @default.
• W2018995079 cites W2138302361 @default.
• W2018995079 cites W2149955110 @default.
• W2018995079 cites W2159087408 @default.
• W2018995079 cites W2166439489 @default.
• W2018995079 cites W2323737915 @default.
• W2018995079 doi "https://doi.org/10.3390/ijms151223059" @default.
• W2018995079 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4284754" @default.
• W2018995079 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25514411" @default.
• W2018995079 hasPublicationYear "2014" @default.
• W2018995079 type Work @default.
• W2018995079 sameAs 2018995079 @default.
• W2018995079 citedByCount "16" @default.
• W2018995079 countsByYear W20189950792015 @default.
• W2018995079 countsByYear W20189950792016 @default.
• W2018995079 countsByYear W20189950792017 @default.
• W2018995079 countsByYear W20189950792018 @default.
• W2018995079 countsByYear W20189950792019 @default.
• W2018995079 countsByYear W20189950792020 @default.
• W2018995079 countsByYear W20189950792021 @default.
• W2018995079 countsByYear W20189950792022 @default.
• W2018995079 countsByYear W20189950792023 @default.
• W2018995079 crossrefType "journal-article" @default.
• W2018995079 hasAuthorship W2018995079A5000401545 @default.
• W2018995079 hasAuthorship W2018995079A5003595535 @default.
• W2018995079 hasAuthorship W2018995079A5011807899 @default.
• W2018995079 hasAuthorship W2018995079A5027083112 @default.
• W2018995079 hasAuthorship W2018995079A5056084869 @default.
• W2018995079 hasAuthorship W2018995079A5067952676 @default.
• W2018995079 hasAuthorship W2018995079A5075653086 @default.
• W2018995079 hasAuthorship W2018995079A5080248487 @default.
• W2018995079 hasAuthorship W2018995079A5085140875 @default.
• W2018995079 hasBestOaLocation W20189950791 @default.
• W2018995079 hasConcept C13591479 @default.
• W2018995079 hasConcept C153911025 @default.
• W2018995079 hasConcept C16525657 @default.
• W2018995079 hasConcept C173358068 @default.
• W2018995079 hasConcept C181199279 @default.
• W2018995079 hasConcept C185592680 @default.
• W2018995079 hasConcept C190283241 @default.
• W2018995079 hasConcept C2779201268 @default.
• W2018995079 hasConcept C2780795997 @default.
• W2018995079 hasConcept C28859421 @default.
• W2018995079 hasConcept C29311851 @default.
• W2018995079 hasConcept C31573885 @default.
• W2018995079 hasConcept C55493867 @default.
• W2018995079 hasConcept C86803240 @default.
• W2018995079 hasConcept C95444343 @default.
• W2018995079 hasConceptScore W2018995079C13591479 @default.
• W2018995079 hasConceptScore W2018995079C153911025 @default.
• W2018995079 hasConceptScore W2018995079C16525657 @default.
• W2018995079 hasConceptScore W2018995079C173358068 @default.
• W2018995079 hasConceptScore W2018995079C181199279 @default.
• W2018995079 hasConceptScore W2018995079C185592680 @default.
• W2018995079 hasConceptScore W2018995079C190283241 @default.
• W2018995079 hasConceptScore W2018995079C2779201268 @default.

• next