FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2018999093> ?p ?o ?g. }

• W2018999093 endingPage "442" @default.
• W2018999093 startingPage "433" @default.
• W2018999093 abstract "The response in cattle to treatment with gonadotrophin releasing hormone (GnRH) agonist includes downregulation of GnRH receptors on gonadotrophe cells, desensitisation of the anterior pituitary gland to endogenous GnRH, and the abolition of pulsatile release of LH. In bulls, a tonic pattern of LH release is associated with increased secretion of testosterone, which persists for the duration of treatment with GnRH agonist. The mechanism for this response in bulls has not been elucidated, but clearly pulsatile release of LH is not required to stimulate the synthesis of steroidogenic enzymes that sustain elevated secretion of testosterone. In heifers, desensitisation to endogenous GnRH prevents the occurrence of the pre-ovulatory surge release of LH, thus blocking ovulation. The latter provided the opportunity to evaluate the potential of a GnRH agonist bioimplant to control fertility in heifers under extensive management. Bioimplants that contained graded amounts of GnRH agonist prevented pregnancies in heifers for periods of 3 to 12 months. Zebu crossbred heifers treated with GnRH agonist from 14 to 23 months of age failed to conceive, but showed normal conception patterns when introduced into mating herds at around 26 months of age. After treatment with GnRH agonist for 4 to 6 weeks, ovarian follicular growth in heifers is restricted to relatively small (2-4 mm) antral follicles. Suppressed follicular growth in heifers treated long-term with GnRH agonist is due to a lack of gonadotrophin support, rather than a direct action of agonist at the ovaries. This was demonstrated by the ability to induce apparently normal follicular growth and ovulation by acute treatment with FSH for 4 days, followed by an injection of LH, in heifers that had been exposed to GnRH agonist for around 6 months, and which had only small (2-4 mm) antral follicles at the start of FSH treatment. GnRH agonist bioimplants have been incorporated into new multiple ovulation and embryo transfer protocols that allow control of the time of ovulation subsequent to superstimulation of ovarian follicular growth with FSH. In these protocols, the endogenous surge release of LH is blocked by treatment with agonist and ovulation is timed by injection of exogenous LH, allowing fixed-time AI. It can be concluded from recent studies that GnRH agonist bioimplants have considerable potential for both pro-fertility and anti-fertility applications in cattle. It is likely that commercial bioimplants will be available within the next 3 to 5 years." @default.
• W2018999093 created "2016-06-24" @default.
• W2018999093 creator A5031927311 @default.
• W2018999093 creator A5049976921 @default.
• W2018999093 creator A5068201262 @default.
• W2018999093 creator A5072265536 @default.
• W2018999093 creator A5085448904 @default.
• W2018999093 date "2000-07-01" @default.
• W2018999093 modified "2023-10-17" @default.
• W2018999093 title "Reproductive responses of cattle to GnRH agonists" @default.
• W2018999093 cites W15811008 @default.
• W2018999093 cites W1963601989 @default.
• W2018999093 cites W1970909590 @default.
• W2018999093 cites W1978223819 @default.
• W2018999093 cites W1985752738 @default.
• W2018999093 cites W1994853202 @default.
• W2018999093 cites W1999841150 @default.
• W2018999093 cites W2009991324 @default.
• W2018999093 cites W2013926000 @default.
• W2018999093 cites W2016496684 @default.
• W2018999093 cites W2032134750 @default.
• W2018999093 cites W2042415727 @default.
• W2018999093 cites W2059644772 @default.
• W2018999093 cites W2062030771 @default.
• W2018999093 cites W2067191413 @default.
• W2018999093 cites W2071967854 @default.
• W2018999093 cites W2095940550 @default.
• W2018999093 cites W2107144284 @default.
• W2018999093 cites W2153442078 @default.
• W2018999093 cites W2172271409 @default.
• W2018999093 cites W2416734035 @default.
• W2018999093 cites W2425765820 @default.
• W2018999093 cites W2461068568 @default.
• W2018999093 cites W4256225119 @default.
• W2018999093 doi "https://doi.org/10.1016/s0378-4320(00)00078-6" @default.
• W2018999093 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10844213" @default.
• W2018999093 hasPublicationYear "2000" @default.
• W2018999093 type Work @default.
• W2018999093 sameAs 2018999093 @default.
• W2018999093 citedByCount "76" @default.
• W2018999093 countsByYear W20189990932013 @default.
• W2018999093 countsByYear W20189990932015 @default.
• W2018999093 countsByYear W20189990932016 @default.
• W2018999093 countsByYear W20189990932017 @default.
• W2018999093 countsByYear W20189990932018 @default.
• W2018999093 countsByYear W20189990932019 @default.
• W2018999093 countsByYear W20189990932021 @default.
• W2018999093 countsByYear W20189990932023 @default.
• W2018999093 crossrefType "journal-article" @default.
• W2018999093 hasAuthorship W2018999093A5031927311 @default.
• W2018999093 hasAuthorship W2018999093A5049976921 @default.
• W2018999093 hasAuthorship W2018999093A5068201262 @default.
• W2018999093 hasAuthorship W2018999093A5072265536 @default.
• W2018999093 hasAuthorship W2018999093A5085448904 @default.
• W2018999093 hasConcept C126322002 @default.
• W2018999093 hasConcept C134018914 @default.
• W2018999093 hasConcept C170493617 @default.
• W2018999093 hasConcept C187785154 @default.
• W2018999093 hasConcept C2777702977 @default.
• W2018999093 hasConcept C2778575703 @default.
• W2018999093 hasConcept C2778894405 @default.
• W2018999093 hasConcept C2778938600 @default.
• W2018999093 hasConcept C71315377 @default.
• W2018999093 hasConcept C71924100 @default.
• W2018999093 hasConcept C86803240 @default.
• W2018999093 hasConceptScore W2018999093C126322002 @default.
• W2018999093 hasConceptScore W2018999093C134018914 @default.
• W2018999093 hasConceptScore W2018999093C170493617 @default.
• W2018999093 hasConceptScore W2018999093C187785154 @default.
• W2018999093 hasConceptScore W2018999093C2777702977 @default.
• W2018999093 hasConceptScore W2018999093C2778575703 @default.
• W2018999093 hasConceptScore W2018999093C2778894405 @default.
• W2018999093 hasConceptScore W2018999093C2778938600 @default.
• W2018999093 hasConceptScore W2018999093C71315377 @default.
• W2018999093 hasConceptScore W2018999093C71924100 @default.
• W2018999093 hasConceptScore W2018999093C86803240 @default.
• W2018999093 hasLocation W20189990931 @default.
• W2018999093 hasLocation W20189990932 @default.
• W2018999093 hasOpenAccess W2018999093 @default.
• W2018999093 hasPrimaryLocation W20189990931 @default.
• W2018999093 hasRelatedWork W1981222718 @default.
• W2018999093 hasRelatedWork W2025304600 @default.
• W2018999093 hasRelatedWork W2027913950 @default.
• W2018999093 hasRelatedWork W2034207006 @default.
• W2018999093 hasRelatedWork W2039465993 @default.
• W2018999093 hasRelatedWork W2061429094 @default.
• W2018999093 hasRelatedWork W2070386770 @default.
• W2018999093 hasRelatedWork W2144089218 @default.
• W2018999093 hasRelatedWork W2164933659 @default.
• W2018999093 hasRelatedWork W4252329896 @default.
• W2018999093 hasVolume "60-61" @default.
• W2018999093 isParatext "false" @default.
• W2018999093 isRetracted "false" @default.
• W2018999093 magId "2018999093" @default.
• W2018999093 workType "article" @default.