FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019000662> ?p ?o ?g. }

• W2019000662 endingPage "859" @default.
• W2019000662 startingPage "850" @default.
• W2019000662 abstract "Bile acids (BAs) are a group of important physiological agents for cholesterol metabolism, intestinal nutrient absorption, and biliary secretion of lipids, toxic metabolites, and xenobiotics. Extensive research in the last two decades has unveiled new functions of BAs as signaling molecules and metabolic regulators that modulate hepatic lipid, glucose, and energy homeostasis through the activation of nuclear receptors and G-protein-coupled receptor signaling in gut-liver metabolic axis involving host-gut microbial co-metabolism. Therefore, investigation of serum BA profiles, in healthy human male and female subjects with a wide range of age and body mass index (BMI), will provide important baseline information on the BA physiology as well as metabolic homeostasis among human subjects that are regulated by two sets of genome, host genome, and symbiotic microbiome. Previous reports on age- or gender-related changes on BA profiles in animals and human showed inconsistent results, and the information acquired from various studies was highly fragmentary. Here we profiled the serum BAs in a large population of healthy participants (n = 502) and examined the impact of age, gender, and BMI on serum BA concentrations and compositions using a targeted metabonomics approach with ultraperformance liquid chromatography triple–quadrupole mass spectrometry. We found that the BA profiles were dependent on gender, age, and BMI among study subjects. The total BAs were significantly higher in males than in females (p < 0.05) and higher in obese females than in lean females (p < 0.05). The difference in BA profiles between male and female subjects was decreased at age of 50–70 years, while the difference in BA profiles between lean and obese increased for subjects aged 50–70 years. The study provides a comprehensive understanding of the BA profiles in healthy subjects and highlights the need to take into account age, gender, and BMI differences when investigating pathophysiological changes of BAs resulting from gastrointestinal diseases." @default.
• W2019000662 created "2016-06-24" @default.
• W2019000662 creator A5001591660 @default.
• W2019000662 creator A5022256556 @default.
• W2019000662 creator A5051833306 @default.
• W2019000662 creator A5054352845 @default.
• W2019000662 creator A5055572946 @default.
• W2019000662 creator A5056450584 @default.
• W2019000662 creator A5069748932 @default.
• W2019000662 creator A5075090550 @default.
• W2019000662 creator A5078882263 @default.
• W2019000662 creator A5085990628 @default.
• W2019000662 creator A5088263932 @default.
• W2019000662 creator A5089609931 @default.
• W2019000662 date "2015-01-27" @default.
• W2019000662 modified "2023-10-15" @default.
• W2019000662 title "Profiling of Serum Bile Acids in a Healthy Chinese Population Using UPLC–MS/MS" @default.
• W2019000662 cites W1499580210 @default.
• W2019000662 cites W1519128746 @default.
• W2019000662 cites W1552008348 @default.
• W2019000662 cites W1606088617 @default.
• W2019000662 cites W1677336966 @default.
• W2019000662 cites W1758546685 @default.
• W2019000662 cites W1975681397 @default.
• W2019000662 cites W1980009386 @default.
• W2019000662 cites W1985151726 @default.
• W2019000662 cites W1985258509 @default.
• W2019000662 cites W1988017103 @default.
• W2019000662 cites W1992862982 @default.
• W2019000662 cites W2033703961 @default.
• W2019000662 cites W2040980930 @default.
• W2019000662 cites W2048876828 @default.
• W2019000662 cites W2051780216 @default.
• W2019000662 cites W2061762739 @default.
• W2019000662 cites W2065424662 @default.
• W2019000662 cites W2077347937 @default.
• W2019000662 cites W2078810890 @default.
• W2019000662 cites W2081028309 @default.
• W2019000662 cites W2082993011 @default.
• W2019000662 cites W2087577664 @default.
• W2019000662 cites W2093465225 @default.
• W2019000662 cites W2102818798 @default.
• W2019000662 cites W2105096193 @default.
• W2019000662 cites W2106515170 @default.
• W2019000662 cites W2110962551 @default.
• W2019000662 cites W2134075987 @default.
• W2019000662 cites W2134897177 @default.
• W2019000662 cites W2138546203 @default.
• W2019000662 cites W2143810054 @default.
• W2019000662 cites W2171578707 @default.
• W2019000662 cites W2312777564 @default.
• W2019000662 cites W2333528204 @default.
• W2019000662 doi "https://doi.org/10.1021/pr500920q" @default.
• W2019000662 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25581415" @default.
• W2019000662 hasPublicationYear "2015" @default.
• W2019000662 type Work @default.
• W2019000662 sameAs 2019000662 @default.
• W2019000662 citedByCount "119" @default.
• W2019000662 countsByYear W20190006622015 @default.
• W2019000662 countsByYear W20190006622016 @default.
• W2019000662 countsByYear W20190006622017 @default.
• W2019000662 countsByYear W20190006622018 @default.
• W2019000662 countsByYear W20190006622019 @default.
• W2019000662 countsByYear W20190006622020 @default.
• W2019000662 countsByYear W20190006622021 @default.
• W2019000662 countsByYear W20190006622022 @default.
• W2019000662 countsByYear W20190006622023 @default.
• W2019000662 crossrefType "journal-article" @default.
• W2019000662 hasAuthorship W2019000662A5001591660 @default.
• W2019000662 hasAuthorship W2019000662A5022256556 @default.
• W2019000662 hasAuthorship W2019000662A5051833306 @default.
• W2019000662 hasAuthorship W2019000662A5054352845 @default.
• W2019000662 hasAuthorship W2019000662A5055572946 @default.
• W2019000662 hasAuthorship W2019000662A5056450584 @default.
• W2019000662 hasAuthorship W2019000662A5069748932 @default.
• W2019000662 hasAuthorship W2019000662A5075090550 @default.
• W2019000662 hasAuthorship W2019000662A5078882263 @default.
• W2019000662 hasAuthorship W2019000662A5085990628 @default.
• W2019000662 hasAuthorship W2019000662A5088263932 @default.
• W2019000662 hasAuthorship W2019000662A5089609931 @default.
• W2019000662 hasConcept C126322002 @default.
• W2019000662 hasConcept C134018914 @default.
• W2019000662 hasConcept C170493617 @default.
• W2019000662 hasConcept C21565614 @default.
• W2019000662 hasConcept C2491326 @default.
• W2019000662 hasConcept C2778163477 @default.
• W2019000662 hasConcept C2780221984 @default.
• W2019000662 hasConcept C2908647359 @default.
• W2019000662 hasConcept C42407357 @default.
• W2019000662 hasConcept C55493867 @default.
• W2019000662 hasConcept C60644358 @default.
• W2019000662 hasConcept C62231903 @default.
• W2019000662 hasConcept C63645605 @default.
• W2019000662 hasConcept C71924100 @default.
• W2019000662 hasConcept C86803240 @default.
• W2019000662 hasConcept C99454951 @default.
• W2019000662 hasConceptScore W2019000662C126322002 @default.
• W2019000662 hasConceptScore W2019000662C134018914 @default.

• next