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• W2019008510 endingPage "171" @default.
• W2019008510 startingPage "164" @default.
• W2019008510 abstract "Methamphetamine (MA) is an abused stimulant which can result in cognitive deficits and monoamine depletions. Animal models of neurotoxic MA exposure show reductions in dopamine, serotonin, and their associated transporters. MA abuse can result in long-term attention, working memory, and executive function deficits in humans and deficits in route-based egocentric learning, novel object recognition, and novel odor preference in rodents. MA has also been shown to affect brain-derived neurotrophic factor (BDNF) in humans and rodents. This experiment examined the effects of a MA binge dosing regimen (10 mg/kg×4 at 2 h intervals, s.c.) in Sprague–Dawley rats on BDNF, tropomyosin receptor kinase B (TrkB), and tyrosine hydroxylase (TH) mRNA expression, and plasma corticosterone. Tissues were collected 1, 7, and 24 h following the last MA dose. Expression of BDNF and TrkB mRNA was analyzed using in situ hybridization with cRNA probes. Frontal, parietal, and entorhinal cortical BDNF mRNA expression were increased by MA exposure at all time-points. Increases in BDNF mRNA were also seen in the hippocampal CA1, prefrontal cortex (PFC), piriform cortex, and locus coeruleus but only at specific times. TrkB mRNA expression was modified in several subregions of the hippocampus as well as in PFC and striatum. TH mRNA was increased at the 1 h time-point in the substantia nigra pars compacta with no differences noted at the other times. Corticosterone levels were increased at all three time-points. The findings suggest that BDNF and its receptor may be upregulated as a compensatory mechanism after MA exposure." @default.
• W2019008510 created "2016-06-24" @default.
• W2019008510 creator A5004631765 @default.
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• W2019008510 creator A5082804242 @default.
• W2019008510 creator A5089828912 @default.
• W2019008510 date "2011-06-01" @default.
• W2019008510 modified "2023-10-12" @default.
• W2019008510 title "Neurotoxic (+)-methamphetamine treatment in rats increases brain-derived neurotrophic factor and tropomyosin receptor kinase B expression in multiple brain regions" @default.
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• W2019008510 doi "https://doi.org/10.1016/j.neuroscience.2011.03.045" @default.
• W2019008510 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3100392" @default.
• W2019008510 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21453757" @default.
• W2019008510 hasPublicationYear "2011" @default.

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