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- W2019011012 abstract "Abstract Metallothioneins (MTs) are low‐molecular weight cysteine‐ and metal‐rich proteins with unquestionable metal binding capacity, antioxidant and anti‐inflammatory properties, and a clear involvement in diverse physiological actions as inhibition of proapoptotic mechanisms, enhancement of cell survival, and tissue regeneration. Concurrent with this wide array of functions, MT‐1/2 have been implicated in neuroprotection and neuroregeneration. The zinc binding capacity and antioxidant properties of MTs may account for most of their physiological features in the brain. However, some receptor‐mediated actions of MT‐1/2 have also been reported recently, a subject to be fully elucidated. This review analyses and updates the current knowledge on the actions of MTs related to neuroprotection and neuroregeneration in an effort to distinguish receptor‐mediated actions of MTs from those arising from its zinc binding capacity and its antioxidant properties. © 2011 IUBMB, IUBMB Life,, 2011." @default.
- W2019011012 created "2016-06-24" @default.
- W2019011012 creator A5006707942 @default.
- W2019011012 creator A5040160716 @default.
- W2019011012 creator A5058741547 @default.
- W2019011012 creator A5078117648 @default.
- W2019011012 date "2011-11-30" @default.
- W2019011012 modified "2023-10-07" @default.
- W2019011012 title "Neuroprotective and neuroregenerative properties of metallothioneins" @default.
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- W2019011012 doi "https://doi.org/10.1002/iub.585" @default.
- W2019011012 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22131188" @default.
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