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- W2019011672 abstract "Abstract Although substance P (SP) is associated with osteoclast differentiation and bone resorption, little is known about the osteogenic differentiation‐inducing effects of SP in periodontal ligament (PDL) cells. This study investigated whether PDL cells could differentiate into osteoblastic‐like cells by SP. The expression of osteoblastic differentiation markers such as osteopontin (OPN), osteonectin (ON), osteocalcin (OCN) and bone sialoprotein (BSP) were evaulated by Western blotting. Additionally, SP‐mediated heme oxygenase‐1 (HO‐1) pathways were further clarified. SP increased HO‐1 and osteogenic differentiation in concentration‐ and time‐dependent manners, as determined by OPN, ON, OCN and BSP expression. Furthermore, treatment with inhibitors of p38, ERK MAPK, and NF‐κB abolished SP‐induced osteogenic differentiation and HO‐1 expression. SP‐induced translocation of Nrf‐2 was also observed. The combined results suggest that SP activates the stress‐response enzymes HO‐1 and Nrf‐2, subsequently leading to upregulation of osteogenic differentiation in human PDL cells." @default.
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- W2019011672 date "2009-03-01" @default.
- W2019011672 modified "2023-10-18" @default.
- W2019011672 title "Effects of substance P on osteoblastic differentiation and heme oxygenase-1 in human periodontal ligament cells" @default.
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- W2019011672 doi "https://doi.org/10.1016/j.cellbi.2008.12.007" @default.
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