FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019011776> ?p ?o ?g. }

• W2019011776 endingPage "220" @default.
• W2019011776 startingPage "209" @default.
• W2019011776 abstract "Evidence is presented for a direct interaction of the intrinsic membrane protein 5'-nucleotidase (5'-ribonucleotide phosphohydrolase, EC 3.1.3.5) purified from avian smooth muscle (chicken gizzard) and the cytoskeletal component actin. Two different modes of interaction can be discerned: firstly, an immediate inhibitory effect of preferentially filamentous actin (F-actin) on the enzymic (i.e., AMPase) activity of 5'-nucleotidase and a direct binding of this enzyme to immobilized F-actin. Since these effects are suppressed by the addition of myosin subfragment 1, binding of 5'-nucleotidase appears to occur along the F-actin filament axis. Secondly, a time- and 5'-nucleotidase concentration-dependent transformation of also preferentially F-actin into a form unable to inhibit the enzymic activity of deoxyribonuclease I (DNAase I). This desensitization of actin versus DNAase I is not due to a denaturation process and was found to be reversible after addition of ATP. Furthermore, it does not seem to effect the ability of actin to bind to DNAase I. The transformation is accompanied by the hydrolysis of actin-bound nucleotide into adenosine, which remains bound to actin. Therefore, the desensitization of actin versus DNAase I appears to be due to a nucleotide-dependent conformational change of actin. An unidentified contamination of the 5'-nucleotidase preparations to a varying degree with ADPase and ATPase activities appears to be responsible for the desensitization process, although a synergistic role of these activities and 5'-nucleotidase cannot be excluded." @default.
• W2019011776 created "2016-06-24" @default.
• W2019011776 creator A5005104073 @default.
• W2019011776 creator A5081928564 @default.
• W2019011776 date "1985-06-01" @default.
• W2019011776 modified "2023-09-25" @default.
• W2019011776 title "The interaction of 5′-nucleotidase purified from chicken gizzard and actin, and the reversible loss of the inhibitory capacity of actin on deoxyribonuclease I" @default.
• W2019011776 cites W1493988254 @default.
• W2019011776 cites W1515770408 @default.
• W2019011776 cites W1550629884 @default.
• W2019011776 cites W1571002099 @default.
• W2019011776 cites W1579521718 @default.
• W2019011776 cites W1974040702 @default.
• W2019011776 cites W198534010 @default.
• W2019011776 cites W1988312243 @default.
• W2019011776 cites W1990232581 @default.
• W2019011776 cites W1993579069 @default.
• W2019011776 cites W1995135269 @default.
• W2019011776 cites W2024979850 @default.
• W2019011776 cites W2027073586 @default.
• W2019011776 cites W2030639097 @default.
• W2019011776 cites W2037841175 @default.
• W2019011776 cites W2039035962 @default.
• W2019011776 cites W2041735329 @default.
• W2019011776 cites W2047831969 @default.
• W2019011776 cites W2056671887 @default.
• W2019011776 cites W2059948706 @default.
• W2019011776 cites W2069377297 @default.
• W2019011776 cites W2071601078 @default.
• W2019011776 cites W2077074448 @default.
• W2019011776 cites W2078241507 @default.
• W2019011776 cites W2083509858 @default.
• W2019011776 cites W2100837269 @default.
• W2019011776 cites W2158692971 @default.
• W2019011776 cites W2239393952 @default.
• W2019011776 cites W2314085531 @default.
• W2019011776 cites W4293247451 @default.
• W2019011776 doi "https://doi.org/10.1016/0167-4838(85)90190-6" @default.
• W2019011776 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2986700" @default.
• W2019011776 hasPublicationYear "1985" @default.
• W2019011776 type Work @default.
• W2019011776 sameAs 2019011776 @default.
• W2019011776 citedByCount "20" @default.
• W2019011776 crossrefType "journal-article" @default.
• W2019011776 hasAuthorship W2019011776A5005104073 @default.
• W2019011776 hasAuthorship W2019011776A5081928564 @default.
• W2019011776 hasConcept C104317684 @default.
• W2019011776 hasConcept C125705527 @default.
• W2019011776 hasConcept C130861313 @default.
• W2019011776 hasConcept C142669718 @default.
• W2019011776 hasConcept C1491633281 @default.
• W2019011776 hasConcept C181199279 @default.
• W2019011776 hasConcept C185592680 @default.
• W2019011776 hasConcept C189040839 @default.
• W2019011776 hasConcept C205875245 @default.
• W2019011776 hasConcept C2776991684 @default.
• W2019011776 hasConcept C2777913276 @default.
• W2019011776 hasConcept C2778659741 @default.
• W2019011776 hasConcept C2779377703 @default.
• W2019011776 hasConcept C2993400109 @default.
• W2019011776 hasConcept C3017666073 @default.
• W2019011776 hasConcept C3620293 @default.
• W2019011776 hasConcept C512185932 @default.
• W2019011776 hasConcept C552990157 @default.
• W2019011776 hasConcept C55493867 @default.
• W2019011776 hasConcept C6997183 @default.
• W2019011776 hasConcept C86803240 @default.
• W2019011776 hasConceptScore W2019011776C104317684 @default.
• W2019011776 hasConceptScore W2019011776C125705527 @default.
• W2019011776 hasConceptScore W2019011776C130861313 @default.
• W2019011776 hasConceptScore W2019011776C142669718 @default.
• W2019011776 hasConceptScore W2019011776C1491633281 @default.
• W2019011776 hasConceptScore W2019011776C181199279 @default.
• W2019011776 hasConceptScore W2019011776C185592680 @default.
• W2019011776 hasConceptScore W2019011776C189040839 @default.
• W2019011776 hasConceptScore W2019011776C205875245 @default.
• W2019011776 hasConceptScore W2019011776C2776991684 @default.
• W2019011776 hasConceptScore W2019011776C2777913276 @default.
• W2019011776 hasConceptScore W2019011776C2778659741 @default.
• W2019011776 hasConceptScore W2019011776C2779377703 @default.
• W2019011776 hasConceptScore W2019011776C2993400109 @default.
• W2019011776 hasConceptScore W2019011776C3017666073 @default.
• W2019011776 hasConceptScore W2019011776C3620293 @default.
• W2019011776 hasConceptScore W2019011776C512185932 @default.
• W2019011776 hasConceptScore W2019011776C552990157 @default.
• W2019011776 hasConceptScore W2019011776C55493867 @default.
• W2019011776 hasConceptScore W2019011776C6997183 @default.
• W2019011776 hasConceptScore W2019011776C86803240 @default.
• W2019011776 hasIssue "2" @default.
• W2019011776 hasLocation W20190117761 @default.
• W2019011776 hasLocation W20190117762 @default.
• W2019011776 hasOpenAccess W2019011776 @default.
• W2019011776 hasPrimaryLocation W20190117761 @default.
• W2019011776 hasRelatedWork W13830274 @default.
• W2019011776 hasRelatedWork W1708389525 @default.
• W2019011776 hasRelatedWork W1967033398 @default.
• W2019011776 hasRelatedWork W1988380573 @default.
• W2019011776 hasRelatedWork W2019011776 @default.

• next