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• W2019012142 abstract "Cells use ions — such as sodium, potassium and calcium — to perform essential biological functions. However, ions cannot cross the cell's lipid membrane; instead ion channels form ‘tunnels’through cell membranes and control the fl ow of ions. Nurse prescribers use drugs targeting ion channels to manage angina, hypertension, cardiac arrhythmias, pain, epilepsy and even influenza. Nevertheless, drugs targeting ion channels have not realized their full potential. Furthermore, alterations in ion channels — which are often genetically determined — contribute to the risk of developing several diseases, including epilepsy, alcoholism and atrial fibrillation. Some alterations can potentially result in serious adverse events with commonly used drugs, and contribute to inter-patient differences in outcomes. This article considers some ion channels currently attracting researchers' attention, to exemplify their clinical potential, and to help nurse prescribers understand how certain drugs act and appreciate the link between abnormal ion channels and disease." @default.
• W2019012142 created "2016-06-24" @default.
• W2019012142 creator A5003239505 @default.
• W2019012142 date "2009-08-01" @default.
• W2019012142 modified "2023-09-26" @default.
• W2019012142 title "Realizing the potential of membrane ion channels" @default.
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• W2019012142 doi "https://doi.org/10.12968/npre.2009.7.8.43687" @default.
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