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- W2019012629 abstract "1. The highly selective 5-HT3-receptor antagonist, GR38032F, has been tested in five animal models predictive for anxiolytic activity. 2. In the social interaction test in the rat and in a light/dark exploration test in the mouse, GR38032F dose-dependently released suppressed behaviour without modifying locomotor activity. 3. In the cynomolgus monkey and the marmoset, GR38032F reduced anxiety-related symptoms without causing sedation. In the marmoset, the effects were clearly dose-related. 4. GR38032F did not have any detectable activity in the water-lick conflict test in the rat. 5. We conclude that GR38032F is potentially a very potent anxiolytic agent without sedative, anticonvulsant or hypnotic activity." @default.
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- W2019012629 date "1988-04-01" @default.
- W2019012629 modified "2023-10-16" @default.
- W2019012629 title "The potential anxiolytic activity of GR38032F, a 5-HT3-receptor antagonist" @default.
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- W2019012629 doi "https://doi.org/10.1111/j.1476-5381.1988.tb11489.x" @default.
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