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- W2019014218 abstract "The deletion (D/D) polymorphism of angiotensin converting enzyme (ACE) gene might be associated with lacunar infarct were proved in previous literatures. And, lacunar stroke play an important role in vascular cognitive impairment (VCI). However, the associations between ACE gene insertion/deletion (indel) polymorphism and VCI in Taiwanese are still undetermined. Between January 2008 and December 2008, we enrolled 65 post-lacunar infarct patients. Lacunar infarct was defined by the Trial of Org 10172 in Acute Stroke Treatment (TOAST) classification. Cognitive Ability Screening Instrument (CASI) and Mini-Mental State Examination (MMSE) were used to evaluate cognitive decline for post-lacunar infarct patients in third and ninth month after stroke, and, we recorded the score difference between these two tests with respect to the ACE insertion/ deletion polymorphism. Chi-Square testing for trend was performed to evaluate the association ACE indel polymorphism with vascular cognitive decline; and logistic regression adjusting for the effects of age, education, gender, and ACE indel polymorphism to evaluate the factors influencing cognitive decline in post-lacunar infarct patients. Among the 65 lacunar infarct patients, 23(35.4%) were women, the mean age was 64.46 ± 12.35 years (26∼88 years old). Twenty-two (33.8%) patients had senior high school education at least, but 10(15.4%) patients were illiterate. After ACE indel polymorphism analysis, 65 of our patients, 7(10.8%) were D/D genotype, 29(44.6%) were I/I genotype, and 29(44.6%) were I/D genotype. In our study, only fluency decline had trended to be not associated with D/D genotype (p = 0.063) in Chi-square testing for trend. CASI (p = 0.407) and MMSE (p = 0.997) did not show significant cognitive decline between these three genotype. After logistic regression analysis, we also did not found any significant difference between cognitive decline and ACE indel polymorphism in post-lacunar infarct patients. Our results can not revealed that ACE indel polymorphism is a predictor of cognitive decline in post-lacunar infarct patients. A partial explanation for this may be that the number of subjects in this study was small, and may not be able to validate the hypothesis estimate exactly. So, extent our study times to collect more patients and long term follow up our cases that may be a reasonable method to improve our results." @default.
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- W2019014218 date "2010-07-01" @default.
- W2019014218 modified "2023-09-27" @default.
- W2019014218 title "P3-136: Angiotensin converting enzyme gene polymorphisms predict cognitive decline in post-lacunar infarct patients" @default.
- W2019014218 doi "https://doi.org/10.1016/j.jalz.2010.05.1633" @default.
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