FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019014987> ?p ?o ?g. }

• W2019014987 endingPage "245" @default.
• W2019014987 startingPage "240" @default.
• W2019014987 abstract "The mutant E270A of Thermus thermophilus 3-isopropylmalate dehydrogenase exhibits largely reduced (∼1%) catalytic activity and negligible activation by K(+) compared to the wild-type enzyme. A 3-4 kcal/mol increase in the activation energy of the catalysed reaction upon this mutation could also be predicted by QM/MM calculations. In the X-ray structure of the E270A mutant a water molecule was observed to take the place of K(+). SAXS and FRET experiments revealed the essential role of E270 in stabilisation of the active domain-closed conformation of the enzyme. In addition, E270 seems to position K(+) into close proximity of the nicotinamide ring of NAD(+) and the electron-withdrawing effect of K(+) may help to polarise the aromatic ring in order to aid the hydride-transfer." @default.
• W2019014987 created "2016-06-24" @default.
• W2019014987 creator A5012234932 @default.
• W2019014987 creator A5037863743 @default.
• W2019014987 creator A5045747363 @default.
• W2019014987 creator A5049758034 @default.
• W2019014987 creator A5052582493 @default.
• W2019014987 creator A5062783046 @default.
• W2019014987 creator A5065944362 @default.
• W2019014987 creator A5072228095 @default.
• W2019014987 creator A5081712139 @default.
• W2019014987 creator A5083741026 @default.
• W2019014987 date "2014-12-10" @default.
• W2019014987 modified "2023-10-05" @default.
• W2019014987 title "Glutamate 270 plays an essential role in K⁺-activation and domain closure of<i>Thermus thermophilus</i>isopropylmalate dehydrogenase" @default.
• W2019014987 cites W1909782247 @default.
• W2019014987 cites W1977038370 @default.
• W2019014987 cites W1977584465 @default.
• W2019014987 cites W1982126789 @default.
• W2019014987 cites W1986408552 @default.
• W2019014987 cites W1987816347 @default.
• W2019014987 cites W1999191323 @default.
• W2019014987 cites W2010860634 @default.
• W2019014987 cites W2029147901 @default.
• W2019014987 cites W2038840577 @default.
• W2019014987 cites W2058376405 @default.
• W2019014987 cites W2059222613 @default.
• W2019014987 cites W2066088601 @default.
• W2019014987 cites W2070929751 @default.
• W2019014987 cites W2121360634 @default.
• W2019014987 cites W2144081223 @default.
• W2019014987 cites W307343023 @default.
• W2019014987 cites W4248872320 @default.
• W2019014987 doi "https://doi.org/10.1016/j.febslet.2014.12.005" @default.
• W2019014987 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25497013" @default.
• W2019014987 hasPublicationYear "2014" @default.
• W2019014987 type Work @default.
• W2019014987 sameAs 2019014987 @default.
• W2019014987 citedByCount "5" @default.
• W2019014987 countsByYear W20190149872016 @default.
• W2019014987 countsByYear W20190149872018 @default.
• W2019014987 countsByYear W20190149872021 @default.
• W2019014987 countsByYear W20190149872023 @default.
• W2019014987 crossrefType "journal-article" @default.
• W2019014987 hasAuthorship W2019014987A5012234932 @default.
• W2019014987 hasAuthorship W2019014987A5037863743 @default.
• W2019014987 hasAuthorship W2019014987A5045747363 @default.
• W2019014987 hasAuthorship W2019014987A5049758034 @default.
• W2019014987 hasAuthorship W2019014987A5052582493 @default.
• W2019014987 hasAuthorship W2019014987A5062783046 @default.
• W2019014987 hasAuthorship W2019014987A5065944362 @default.
• W2019014987 hasAuthorship W2019014987A5072228095 @default.
• W2019014987 hasAuthorship W2019014987A5081712139 @default.
• W2019014987 hasAuthorship W2019014987A5083741026 @default.
• W2019014987 hasBestOaLocation W20190149871 @default.
• W2019014987 hasConcept C104317684 @default.
• W2019014987 hasConcept C143065580 @default.
• W2019014987 hasConcept C178790620 @default.
• W2019014987 hasConcept C181199279 @default.
• W2019014987 hasConcept C185592680 @default.
• W2019014987 hasConcept C2776317432 @default.
• W2019014987 hasConcept C2779268744 @default.
• W2019014987 hasConcept C2780378348 @default.
• W2019014987 hasConcept C2780883830 @default.
• W2019014987 hasConcept C41183919 @default.
• W2019014987 hasConcept C547475151 @default.
• W2019014987 hasConcept C55493867 @default.
• W2019014987 hasConcept C71240020 @default.
• W2019014987 hasConcept C75520062 @default.
• W2019014987 hasConcept C8010536 @default.
• W2019014987 hasConceptScore W2019014987C104317684 @default.
• W2019014987 hasConceptScore W2019014987C143065580 @default.
• W2019014987 hasConceptScore W2019014987C178790620 @default.
• W2019014987 hasConceptScore W2019014987C181199279 @default.
• W2019014987 hasConceptScore W2019014987C185592680 @default.
• W2019014987 hasConceptScore W2019014987C2776317432 @default.
• W2019014987 hasConceptScore W2019014987C2779268744 @default.
• W2019014987 hasConceptScore W2019014987C2780378348 @default.
• W2019014987 hasConceptScore W2019014987C2780883830 @default.
• W2019014987 hasConceptScore W2019014987C41183919 @default.
• W2019014987 hasConceptScore W2019014987C547475151 @default.
• W2019014987 hasConceptScore W2019014987C55493867 @default.
• W2019014987 hasConceptScore W2019014987C71240020 @default.
• W2019014987 hasConceptScore W2019014987C75520062 @default.
• W2019014987 hasConceptScore W2019014987C8010536 @default.
• W2019014987 hasFunder F4320321994 @default.
• W2019014987 hasIssue "2" @default.
• W2019014987 hasLocation W20190149871 @default.
• W2019014987 hasLocation W20190149872 @default.
• W2019014987 hasLocation W20190149873 @default.
• W2019014987 hasOpenAccess W2019014987 @default.
• W2019014987 hasPrimaryLocation W20190149871 @default.
• W2019014987 hasRelatedWork W2005703273 @default.
• W2019014987 hasRelatedWork W2021487571 @default.
• W2019014987 hasRelatedWork W2063845813 @default.
• W2019014987 hasRelatedWork W2065559700 @default.
• W2019014987 hasRelatedWork W2072863030 @default.
• W2019014987 hasRelatedWork W2086755521 @default.

• next