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• W2019016671 abstract "Purpose We investigated the place of direct plasma cell proliferation analysis beside other biologic data in monoclonal gammopathy, particularly the serum level of C-reactive protein (C-RP) Patients Eighty patients were studied at the time of their diagnosis. Patients with a serum creatinine level greater than 200 μmol/L were excluded. Methods Plasma cell proliferation analysis was performed after bromodeoxyuridine incorporation and double immunoenzymatic labeling on cytological smears, making determination of the plasma cell labeling index (LI) possible. The other biologic variables studied were related to tumor burden (plasmacytosis, hemoglobin, serum levels of monoclonal immunoglobulin, albumin) or to kidney function (creatinine). β2-microglobulin (β2-M), C-RP, lactic dehydrogenase (LDH), and calcemia were also assessed. Results No correlation was found between LI and serum C-RP. LDH was the sole variable significantly correlated to C-RP (P <0.01). Besides the biologic parameters used for the staging according to the Durie and Salmon classification, β2-M, albumin and LI were significantly different between stages (P <0.0002, <0.0004, <0.00001). LDH and C-RP showed no significant difference. Results were similar when patients with and without bone lesions were analyzed separately. Multivariate analysis ranked these variables as follows with respect to prognostic value: β2-M, LI, and age. Conclusion Among the variables analyzed, LI is the sole true reflector of cell proliferation. We confirm its diagnostic and prognostic value. We investigated the place of direct plasma cell proliferation analysis beside other biologic data in monoclonal gammopathy, particularly the serum level of C-reactive protein (C-RP) Eighty patients were studied at the time of their diagnosis. Patients with a serum creatinine level greater than 200 μmol/L were excluded. Plasma cell proliferation analysis was performed after bromodeoxyuridine incorporation and double immunoenzymatic labeling on cytological smears, making determination of the plasma cell labeling index (LI) possible. The other biologic variables studied were related to tumor burden (plasmacytosis, hemoglobin, serum levels of monoclonal immunoglobulin, albumin) or to kidney function (creatinine). β2-microglobulin (β2-M), C-RP, lactic dehydrogenase (LDH), and calcemia were also assessed. No correlation was found between LI and serum C-RP. LDH was the sole variable significantly correlated to C-RP (P <0.01). Besides the biologic parameters used for the staging according to the Durie and Salmon classification, β2-M, albumin and LI were significantly different between stages (P <0.0002, <0.0004, <0.00001). LDH and C-RP showed no significant difference. Results were similar when patients with and without bone lesions were analyzed separately. Multivariate analysis ranked these variables as follows with respect to prognostic value: β2-M, LI, and age. Among the variables analyzed, LI is the sole true reflector of cell proliferation. We confirm its diagnostic and prognostic value." @default.
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• W2019016671 date "1995-01-01" @default.
• W2019016671 modified "2023-10-18" @default.
• W2019016671 title "Plasma cell proliferation in monoclonal gammopathy: Relations with other biologic variables—Diagnostic and prognostic significance" @default.
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• W2019016671 doi "https://doi.org/10.1016/s0002-9343(99)80081-3" @default.
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