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- W2019017654 abstract "Here we report the electrophysiology of an engineered nanopore mediated by the capsid portal protein GP10 and several mutants in a freestanding lipid bilayer. The measured conductance is on par with some of the largest biological nanopores, like those of the mechanosensitive channels and porins found in many prokaryotes. Conductance appears to be restricted by both the variable region and the c-terminal crown, areas known to interact with the viral DNA but unresolved in the crystal structure. We have used the c-terminal interaction as a basis for distinguishing dsDNA methylation state by engineering a methylated DNA binding domain onto the crown of GP10. The engineered pore has the ability to electrically distinguish methylated and hydroxymethylated DNA from the unmodified form. We envision this sensor as a future tool for detecting the alterations in DNA methylation state commonly associated with carcinogenesis." @default.
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- W2019017654 date "2012-01-01" @default.
- W2019017654 modified "2023-09-30" @default.
- W2019017654 title "A DNA Methylation Sensitive Nanopore Engineered from the phi29 Portal Protein GP10" @default.
- W2019017654 doi "https://doi.org/10.1016/j.bpj.2011.11.1121" @default.
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