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• W2019019767 abstract "Paediatric respiratory-tract infections are a common and major source of morbidity and mortality worldwide, particularly in developing countries. Pneumonia is the leading cause of mortality in children younger than 5 years: every year, 1·4–1·6 million young children die from this infection and up to 13% of roughly 155 million episodes are severe enough to warrant hospital admission. 1 Rudan I El Arifeen S Bhutta ZA et al. and the WHO/CHNRI Expert Group on Childhood PneumoniaSetting research priorities to reduce global mortality from childhood pneumonia by 2015. PLoS Med. 2011; 8: e1001099 Crossref PubMed Scopus (85) Google Scholar , 2 Liu L Johnson HL Cousens S et al. for the Child Health Epidemiology Reference Group of WHO and UNICEFGlobal, regional, and national causes of child mortality: an updated systematic analysis for 2010 with time trends since 2000. Lancet. 2012; 379: 2151-2161 Summary Full Text Full Text PDF PubMed Scopus (2641) Google Scholar Respiratory-tract infections are caused by a mixture of viral and bacterial pathogens and are particularly common in low birthweight children and children exposed to poor nutritional conditions, indoor air pollution, low socioeconomic status, overcrowded living conditions, HIV co-infection, vitamin D deficiency, and low immunisation coverage. 3 Gilani Z Kwong YD Levine OS et al. A literature review and survey of childhood pneumonia etiology studies: 2000–2010. Clin Infect Dis. 2012; 54: S102-S108 Crossref PubMed Scopus (41) Google Scholar , 4 Wonodi CB Deloria-Knoll M Feikin DR et al. for the Pneumonia Methods Working Group and PERCH Site InvestigatorsEvaluation of risk factors for severe pneumonia in children: the Pneumonia Etiology Research for Child Health study. Clin Infect Dis. 2012; 54: S124-S131 Crossref PubMed Scopus (43) Google Scholar Pneumonia not only has an immediate effect during childhood, but can also lead to impaired lung function years later in adulthood. 5 Johnston I Strachan DP Anderson HR Effect of pneumonia and whooping cough in childhood on adult lung function. N Engl J Med. 1998; 338: 581-587 Crossref PubMed Scopus (142) Google Scholar Furthermore, children can be a source of drug-resistant pneumococci, as shown by the reduction in rates of adult pneumonia when children received pneumococcal conjugate vaccine. 6 Kyaw MH Lynfield R Schaffner W et al. for the Active Bacterial Core Surveillance of the Emerging Infections Program NetworkEffect of introduction of the pneumococcal conjugate vaccine on drug-resistant Streptococcus pneumoniae. N Engl J Med. 2006; 354: 1455-1463 Crossref PubMed Scopus (707) Google Scholar In view of the magnitude of the problem, the Bill & Melinda Gates Foundation has made childhood pneumonia a research priority through support of programmes that will apply new diagnostic and management methods. 7 Adegbola RA Childhood pneumonia as a global health priority and the strategic interest of The Bill & Melinda Gates Foundation. Clin Infect Dis. 2012; 54: S89-S92 Crossref PubMed Scopus (35) Google Scholar Global and regional burden of hospital admissions for severe acute lower respiratory infections in young children in 2010: a systematic analysisSevere ALRI is a substantial burden on health services worldwide and a major cause of hospital referral and admission in young children. Improved hospital access and reduced inequities, such as those related to sex and rural status, could substantially decrease mortality related to such infection. Community-based management of severe disease could be an important complementary strategy to reduce pneumonia mortality and health inequities. Full-Text PDF Open Access" @default.
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• W2019019767 title "Acute lower respiratory infections in developing countries" @default.
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