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- W2019023689 abstract "The synthetic antiprotease, FUT-175 (6-amidino-2-naphthyl-4-guanidinobenzoate), was found to be an extraordinarily potent and rapid inhibitor of human Q31 cytotoxic T-lymphocyte granzyme A. The granzyme A was inhibited in a time-dependent manner with kobsi = 430,000 ± 80,000 M−1 s−1. Four other FUT-175 analogs were also found to be potent, rapid Q31 granzyme A inhibitors. All five compounds inhibited Q31 cytotoxic Tlymphocyte-mediated cytolysis of human JY lymphoma cells, but at concentrations far in excess of those needed for granzyme A inhibition. The data presented suggest that postmarketing surveillance of FUT-175 should include a review of possible immunosuppressive side-effects, such as increased susceptibility to viral infections and to neoplastic transformations." @default.
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- W2019023689 date "1991-01-01" @default.
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- W2019023689 title "The enzymatic activity of human cytotoxic T-lymphocyte granzyme a and cytolysis mediated by cytotoxic T-lymphocytes are potently inhibited by a synthetic antiprotease, FUT-175" @default.
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- W2019023689 doi "https://doi.org/10.1016/0003-9861(91)90286-r" @default.
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