FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019025595> ?p ?o ?g. }

• W2019025595 endingPage "104" @default.
• W2019025595 startingPage "91" @default.
• W2019025595 abstract "The posterior lateral line (PLL) system in zebrafish has recently become a model for investigating tissue morphogenesis. PLL primordium periodically deposits neuromasts as it migrates along the horizontal myoseptum from head to tail of the embryonic fish, and this migration requires activity of various molecular mechanisms. Histone deacetylases (HDACs) have been implicated in numerous biological processes of development, by regulating gene transcription, but their roles in regulating PLL during embryonic development have up to now remained unexplored.In this study, we used HDAC inhibitors to investigate the role of HDACs in early development of the zebrafish PLL sensory system. We further investigated development of the PLL by cell-specific immunostaining and in situ hybridization.Our analysis showed that HDACs were involved in zebrafish PLL development as pharmacological inhibition of HDACs resulted in its defective formation. We observed that migration of PLL primordium was altered and accompanied by disrupted development of PLL neuromasts in HDAC inhibitor-treated embryos. In these, positions of PLL neuromasts were affected. In particular, the first PLL neuromast was displaced posteriorly in a treatment dose-dependent manner. Primordium cell proliferation was reduced upon HDAC inhibition. Finally, we showed that inhibition of HDAC function reduced numbers of hair cells in PLL neuromasts of HDAC inhibitor-treated embryos.Here, we have revealed a novel role for HDACs in orchestrating PLL morphogenesis. Our results suggest that HDAC activity is necessary for control of cell proliferation and migration of PLL primordium and hair cell differentiation during early stages of PLL development in zebrafish." @default.
• W2019025595 created "2016-06-24" @default.
• W2019025595 creator A5003012923 @default.
• W2019025595 creator A5008775437 @default.
• W2019025595 creator A5036058754 @default.
• W2019025595 creator A5036452981 @default.
• W2019025595 creator A5048758517 @default.
• W2019025595 creator A5054616509 @default.
• W2019025595 creator A5064260089 @default.
• W2019025595 date "2013-11-23" @default.
• W2019025595 modified "2023-09-27" @default.
• W2019025595 title "Histone deacetylase activity is required for embryonic posterior lateral line development" @default.
• W2019025595 cites W1591579569 @default.
• W2019025595 cites W1658998365 @default.
• W2019025595 cites W1910848366 @default.
• W2019025595 cites W1968802624 @default.
• W2019025595 cites W1969386224 @default.
• W2019025595 cites W1969575562 @default.
• W2019025595 cites W1993087406 @default.
• W2019025595 cites W1994189400 @default.
• W2019025595 cites W2002698073 @default.
• W2019025595 cites W2005928381 @default.
• W2019025595 cites W2007727790 @default.
• W2019025595 cites W2010516412 @default.
• W2019025595 cites W2015219117 @default.
• W2019025595 cites W2015893726 @default.
• W2019025595 cites W2032725114 @default.
• W2019025595 cites W2032817067 @default.
• W2019025595 cites W2043351945 @default.
• W2019025595 cites W2043975447 @default.
• W2019025595 cites W2054312696 @default.
• W2019025595 cites W2054378694 @default.
• W2019025595 cites W2058623849 @default.
• W2019025595 cites W2061849077 @default.
• W2019025595 cites W2066264051 @default.
• W2019025595 cites W2076794567 @default.
• W2019025595 cites W2078503423 @default.
• W2019025595 cites W2079894711 @default.
• W2019025595 cites W2083231860 @default.
• W2019025595 cites W2084616066 @default.
• W2019025595 cites W2089096062 @default.
• W2019025595 cites W2089941463 @default.
• W2019025595 cites W2107733280 @default.
• W2019025595 cites W2108017291 @default.
• W2019025595 cites W2110737176 @default.
• W2019025595 cites W2110938577 @default.
• W2019025595 cites W2117691193 @default.
• W2019025595 cites W2123577119 @default.
• W2019025595 cites W2124994200 @default.
• W2019025595 cites W2125349610 @default.
• W2019025595 cites W2130610203 @default.
• W2019025595 cites W2130814212 @default.
• W2019025595 cites W2135085078 @default.
• W2019025595 cites W2143027433 @default.
• W2019025595 cites W2143658931 @default.
• W2019025595 cites W2167422334 @default.
• W2019025595 cites W2171102198 @default.
• W2019025595 cites W4251934001 @default.
• W2019025595 doi "https://doi.org/10.1111/cpr.12081" @default.
• W2019025595 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6496587" @default.
• W2019025595 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24267956" @default.
• W2019025595 hasPublicationYear "2013" @default.
• W2019025595 type Work @default.
• W2019025595 sameAs 2019025595 @default.
• W2019025595 citedByCount "16" @default.
• W2019025595 countsByYear W20190255952014 @default.
• W2019025595 countsByYear W20190255952015 @default.
• W2019025595 countsByYear W20190255952016 @default.
• W2019025595 countsByYear W20190255952017 @default.
• W2019025595 countsByYear W20190255952019 @default.
• W2019025595 countsByYear W20190255952021 @default.
• W2019025595 countsByYear W20190255952022 @default.
• W2019025595 crossrefType "journal-article" @default.
• W2019025595 hasAuthorship W2019025595A5003012923 @default.
• W2019025595 hasAuthorship W2019025595A5008775437 @default.
• W2019025595 hasAuthorship W2019025595A5036058754 @default.
• W2019025595 hasAuthorship W2019025595A5036452981 @default.
• W2019025595 hasAuthorship W2019025595A5048758517 @default.
• W2019025595 hasAuthorship W2019025595A5054616509 @default.
• W2019025595 hasAuthorship W2019025595A5064260089 @default.
• W2019025595 hasBestOaLocation W20190255952 @default.
• W2019025595 hasConcept C104317684 @default.
• W2019025595 hasConcept C184750944 @default.
• W2019025595 hasConcept C2776878037 @default.
• W2019025595 hasConcept C2778305200 @default.
• W2019025595 hasConcept C40692019 @default.
• W2019025595 hasConcept C53273792 @default.
• W2019025595 hasConcept C54355233 @default.
• W2019025595 hasConcept C64927066 @default.
• W2019025595 hasConcept C86803240 @default.
• W2019025595 hasConcept C95444343 @default.
• W2019025595 hasConceptScore W2019025595C104317684 @default.
• W2019025595 hasConceptScore W2019025595C184750944 @default.
• W2019025595 hasConceptScore W2019025595C2776878037 @default.
• W2019025595 hasConceptScore W2019025595C2778305200 @default.
• W2019025595 hasConceptScore W2019025595C40692019 @default.
• W2019025595 hasConceptScore W2019025595C53273792 @default.
• W2019025595 hasConceptScore W2019025595C54355233 @default.

• next