FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019027336> ?p ?o ?g. }

• W2019027336 endingPage "152" @default.
• W2019027336 startingPage "144" @default.
• W2019027336 abstract "Increased levels of glucocorticoid hormones—the main product of the hypothalamic‐pituitary‐adrenal (HPA) axis—have been considered to be “depressogenic,” but this notion has largely derived from studies in patients with endocrine conditions, such as Cushing's syndrome or exogenous treatment with synthetic glucocorticoids. In these conditions, it is likely that the full impact of the high glucocorticoid levels is felt on the brain, through over‐stimulation of the glucocorticoid receptors (GRs); indeed, normalizing these high levels leads to an improvement of mood in these patients. However, a completely different mechanism may be operating in major depression, where the increased levels of glucocorticoid hormones are conceptualized as driven by an impairment in GR function (glucocorticoid resistance), and therefore as a “compensatory” mechanism. Moreover, clinical and experimental studies have shown that antidepressants increase GR function, thus leading to resolution of glucocorticoid resistance. Interestingly, a number of studies have also demonstrated that manipulating GR function with both agonists and antagonists has an antidepressant effect, and indeed that other drugs targeting the HPA axis and cortisol secretion—even drugs with opposite effects on the HPA axis—have antidepressant effects. These studies do not support the notion that “high levels of glucocorticoids” always have a depressogenic effect, nor that decreasing the effects of these hormones always has an antidepressant effects." @default.
• W2019027336 created "2016-06-24" @default.
• W2019027336 creator A5085756728 @default.
• W2019027336 date "2009-10-01" @default.
• W2019027336 modified "2023-10-03" @default.
• W2019027336 title "Risk Factors for Development of Depression and Psychosis" @default.
• W2019027336 cites W1967122944 @default.
• W2019027336 cites W1972822291 @default.
• W2019027336 cites W1976951750 @default.
• W2019027336 cites W1977977170 @default.
• W2019027336 cites W1978625524 @default.
• W2019027336 cites W1979563389 @default.
• W2019027336 cites W1982225511 @default.
• W2019027336 cites W1988200312 @default.
• W2019027336 cites W1997282991 @default.
• W2019027336 cites W1998319883 @default.
• W2019027336 cites W1998842387 @default.
• W2019027336 cites W2001257694 @default.
• W2019027336 cites W2001313965 @default.
• W2019027336 cites W2005219438 @default.
• W2019027336 cites W2007636259 @default.
• W2019027336 cites W2009700275 @default.
• W2019027336 cites W2009754149 @default.
• W2019027336 cites W2017644039 @default.
• W2019027336 cites W2024340213 @default.
• W2019027336 cites W2027582479 @default.
• W2019027336 cites W2041573038 @default.
• W2019027336 cites W2044775217 @default.
• W2019027336 cites W2045322458 @default.
• W2019027336 cites W2048418520 @default.
• W2019027336 cites W2050463389 @default.
• W2019027336 cites W2051225255 @default.
• W2019027336 cites W2051773374 @default.
• W2019027336 cites W2056750568 @default.
• W2019027336 cites W2056771515 @default.
• W2019027336 cites W2057485304 @default.
• W2019027336 cites W2060491921 @default.
• W2019027336 cites W2060503785 @default.
• W2019027336 cites W2065124716 @default.
• W2019027336 cites W2071272920 @default.
• W2019027336 cites W2071820126 @default.
• W2019027336 cites W2073054864 @default.
• W2019027336 cites W2073216156 @default.
• W2019027336 cites W2080795205 @default.
• W2019027336 cites W2084399551 @default.
• W2019027336 cites W2091200799 @default.
• W2019027336 cites W2091240992 @default.
• W2019027336 cites W2093478061 @default.
• W2019027336 cites W2094716450 @default.
• W2019027336 cites W2095529980 @default.
• W2019027336 cites W2097740790 @default.
• W2019027336 cites W2101585433 @default.
• W2019027336 cites W2118210398 @default.
• W2019027336 cites W2123512145 @default.
• W2019027336 cites W2123978052 @default.
• W2019027336 cites W2132731742 @default.
• W2019027336 cites W2132993734 @default.
• W2019027336 cites W2139287106 @default.
• W2019027336 cites W2154712992 @default.
• W2019027336 cites W2156505367 @default.
• W2019027336 cites W4237348831 @default.
• W2019027336 cites W4250116403 @default.
• W2019027336 cites W69500316 @default.
• W2019027336 doi "https://doi.org/10.1111/j.1749-6632.2009.04978.x" @default.
• W2019027336 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2982725" @default.
• W2019027336 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19906237" @default.
• W2019027336 hasPublicationYear "2009" @default.
• W2019027336 type Work @default.
• W2019027336 sameAs 2019027336 @default.
• W2019027336 citedByCount "159" @default.
• W2019027336 countsByYear W20190273362012 @default.
• W2019027336 countsByYear W20190273362013 @default.
• W2019027336 countsByYear W20190273362014 @default.
• W2019027336 countsByYear W20190273362015 @default.
• W2019027336 countsByYear W20190273362016 @default.
• W2019027336 countsByYear W20190273362017 @default.
• W2019027336 countsByYear W20190273362018 @default.
• W2019027336 countsByYear W20190273362019 @default.
• W2019027336 countsByYear W20190273362020 @default.
• W2019027336 countsByYear W20190273362021 @default.
• W2019027336 countsByYear W20190273362022 @default.
• W2019027336 countsByYear W20190273362023 @default.
• W2019027336 crossrefType "journal-article" @default.
• W2019027336 hasAuthorship W2019027336A5085756728 @default.
• W2019027336 hasBestOaLocation W20190273362 @default.
• W2019027336 hasConcept C118552586 @default.
• W2019027336 hasConcept C126322002 @default.
• W2019027336 hasConcept C134018914 @default.
• W2019027336 hasConcept C15744967 @default.
• W2019027336 hasConcept C24998067 @default.
• W2019027336 hasConcept C2777134132 @default.
• W2019027336 hasConcept C2779177272 @default.
• W2019027336 hasConcept C2779727114 @default.
• W2019027336 hasConcept C2780733359 @default.
• W2019027336 hasConcept C2780841215 @default.
• W2019027336 hasConcept C2781161787 @default.
• W2019027336 hasConcept C46699223 @default.
• W2019027336 hasConcept C558461103 @default.

• next