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- W2019032895 abstract "The Na(+)-K(+) pump is an essential heterodimeric membrane protein, which maintains electrochemical gradients for Na(+) and K(+) across cell membranes in all tissues. We have identified glutathionylation, a reversible posttranslational redox modification, of the Na(+)-K(+) pump's β1 subunit as a regulatory mechanism of pump activity. Oxidative inhibition of the Na(+)-K(+) pump by angiotensin II- and β1-adrenergic receptor-coupled signaling via NADPH oxidase activation demonstrates the relevance of this regulatory mechanism in cardiovascular physiology and pathophysiology. This has implications for dysregulation of intracellular Na(+) and Ca(2+) as well as increased oxidative stress in heart failure, myocardial ischemia-reperfusion, and regulation of vascular tone under conditions of elevated oxidative stress. Treatment strategies that are able to reverse this oxidative inhibition of the Na(+)-K(+) pump have the potential for cardiovascular-protective effects." @default.
- W2019032895 created "2016-06-24" @default.
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- W2019032895 date "2012-12-01" @default.
- W2019032895 modified "2023-10-05" @default.
- W2019032895 title "Oxidative regulation of the Na+–K+ pump in the cardiovascular system" @default.
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- W2019032895 doi "https://doi.org/10.1016/j.freeradbiomed.2012.10.539" @default.
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