Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019033121> ?p ?o ?g. }
Showing items 1 to 91 of
91
with 100 items per page.
- W2019033121 endingPage "429" @default.
- W2019033121 startingPage "422" @default.
- W2019033121 abstract "A plateau in long-term survival patterns of patients undergoing blood and marrow transplantation (BMT) from allogeneic donors is apparent, but whether their expected survival ever parallels that of the normative population is unclear. This study attempts to identify a cutoff time for classifying BMT patients as long-term survivors and compares their actual survival with the expected survival of an age- and gender-matched “normal” population. In this study, the records of 1386 patients who underwent allogeneic BMT at Princess Margaret Hospital between 1970 and 2002 were reviewed. Hazard rates (HRs), Kaplan-Meier survival estimates, and loess curves were used to propose a cutoff time classifying patients as long-term survivors. Factors predictive of overall survival and survival for long-term survivors were investigated. Actual survival for these patients was compared with the expected survival of the Canadian “normal” population. A cutoff time of 6 years post-BMT was proposed to define long-term survivors based on loess curves of hazard ratios and yearly survival statistics. The only statistically significant predictor of survival among long-term survivors was having a male donor (HR = 0.39; 95% confidence interval [CI] = 0.17–0.88). Although only 62% of patients survived the first year post-BMT, 98.5% of patients alive after 6 years survived at least another year. Almost 1/3 (31%) of the deaths in long-term survivors resulted from causes unrelated to transplantation or relapse. The observed number of deaths among BMT patients exceeded the expected number from the Canadian population; however, the difference in life expectancy decreased the longer that a patient survived. The 95% CIs for the observed/expected number of deaths cover 1, indicative of no difference, after the tenth year post-BMT. A cutoff of 6 years is proposed to define long-term survivorship after BMT. Life expectancy remained reduced compared with that of the “normal” population; however, this difference decreased the longer that a patient survived. Known risk factors of short-term survival disappeared, with only donor gender predictive of survival among long-term survivors." @default.
- W2019033121 created "2016-06-24" @default.
- W2019033121 creator A5014346242 @default.
- W2019033121 creator A5042152459 @default.
- W2019033121 creator A5047689900 @default.
- W2019033121 date "2006-04-01" @default.
- W2019033121 modified "2023-10-03" @default.
- W2019033121 title "Long-Term Survival after Blood and Marrow Transplantation: Comparison with an Age- and Gender-Matched Normative Population" @default.
- W2019033121 cites W1979578577 @default.
- W2019033121 cites W2002577582 @default.
- W2019033121 cites W2017977879 @default.
- W2019033121 cites W2025563939 @default.
- W2019033121 cites W2082143429 @default.
- W2019033121 cites W4253242430 @default.
- W2019033121 cites W4293241248 @default.
- W2019033121 doi "https://doi.org/10.1016/j.bbmt.2005.11.518" @default.
- W2019033121 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16545726" @default.
- W2019033121 hasPublicationYear "2006" @default.
- W2019033121 type Work @default.
- W2019033121 sameAs 2019033121 @default.
- W2019033121 citedByCount "39" @default.
- W2019033121 countsByYear W20190331212012 @default.
- W2019033121 countsByYear W20190331212013 @default.
- W2019033121 countsByYear W20190331212014 @default.
- W2019033121 countsByYear W20190331212015 @default.
- W2019033121 countsByYear W20190331212016 @default.
- W2019033121 countsByYear W20190331212017 @default.
- W2019033121 countsByYear W20190331212018 @default.
- W2019033121 countsByYear W20190331212019 @default.
- W2019033121 countsByYear W20190331212020 @default.
- W2019033121 countsByYear W20190331212021 @default.
- W2019033121 countsByYear W20190331212023 @default.
- W2019033121 crossrefType "journal-article" @default.
- W2019033121 hasAuthorship W2019033121A5014346242 @default.
- W2019033121 hasAuthorship W2019033121A5042152459 @default.
- W2019033121 hasAuthorship W2019033121A5047689900 @default.
- W2019033121 hasBestOaLocation W20190331211 @default.
- W2019033121 hasConcept C10515644 @default.
- W2019033121 hasConcept C121332964 @default.
- W2019033121 hasConcept C126322002 @default.
- W2019033121 hasConcept C141071460 @default.
- W2019033121 hasConcept C144024400 @default.
- W2019033121 hasConcept C149923435 @default.
- W2019033121 hasConcept C207103383 @default.
- W2019033121 hasConcept C2776283816 @default.
- W2019033121 hasConcept C2778217198 @default.
- W2019033121 hasConcept C2908647359 @default.
- W2019033121 hasConcept C2911091166 @default.
- W2019033121 hasConcept C44249647 @default.
- W2019033121 hasConcept C50382708 @default.
- W2019033121 hasConcept C62520636 @default.
- W2019033121 hasConcept C71924100 @default.
- W2019033121 hasConcept C99454951 @default.
- W2019033121 hasConceptScore W2019033121C10515644 @default.
- W2019033121 hasConceptScore W2019033121C121332964 @default.
- W2019033121 hasConceptScore W2019033121C126322002 @default.
- W2019033121 hasConceptScore W2019033121C141071460 @default.
- W2019033121 hasConceptScore W2019033121C144024400 @default.
- W2019033121 hasConceptScore W2019033121C149923435 @default.
- W2019033121 hasConceptScore W2019033121C207103383 @default.
- W2019033121 hasConceptScore W2019033121C2776283816 @default.
- W2019033121 hasConceptScore W2019033121C2778217198 @default.
- W2019033121 hasConceptScore W2019033121C2908647359 @default.
- W2019033121 hasConceptScore W2019033121C2911091166 @default.
- W2019033121 hasConceptScore W2019033121C44249647 @default.
- W2019033121 hasConceptScore W2019033121C50382708 @default.
- W2019033121 hasConceptScore W2019033121C62520636 @default.
- W2019033121 hasConceptScore W2019033121C71924100 @default.
- W2019033121 hasConceptScore W2019033121C99454951 @default.
- W2019033121 hasIssue "4" @default.
- W2019033121 hasLocation W20190331211 @default.
- W2019033121 hasLocation W20190331212 @default.
- W2019033121 hasOpenAccess W2019033121 @default.
- W2019033121 hasPrimaryLocation W20190331211 @default.
- W2019033121 hasRelatedWork W2088206352 @default.
- W2019033121 hasRelatedWork W2119154902 @default.
- W2019033121 hasRelatedWork W2130909087 @default.
- W2019033121 hasRelatedWork W2133235702 @default.
- W2019033121 hasRelatedWork W2145587586 @default.
- W2019033121 hasRelatedWork W2203903734 @default.
- W2019033121 hasRelatedWork W2298739133 @default.
- W2019033121 hasRelatedWork W2782540009 @default.
- W2019033121 hasRelatedWork W2917746345 @default.
- W2019033121 hasRelatedWork W3086255011 @default.
- W2019033121 hasVolume "12" @default.
- W2019033121 isParatext "false" @default.
- W2019033121 isRetracted "false" @default.
- W2019033121 magId "2019033121" @default.
- W2019033121 workType "article" @default.