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- W2019033423 abstract "Scope Oxidative stress plays a pivotal role in the pathophysiology of cardiovascular diseases. Oxidized low-density lipoprotein (oxLDL) is a key contributor to atherogenesis through multiple mechanisms. In this study, we investigated the protection by three structurally related isothiocyanates, i.e., sulforaphane (SFN), benzyl isothiocyanate (BITC), and phenethyl isocyanate (PEITC), against oxLDL-induced leukocyte adhesion to vascular endothelium and the mechanism involved. Methods and results The protection against oxLDL-induced endothelial dysfunction by isothiocyanates was studied in human umbilical vein endothelial cells (HUVECs). oxLDL increased reactive oxygen species (ROS) production, stimulated nuclear factor-kappaB (NFκB) activation, and enhanced intercellular adhesion molecule 1 (ICAM-1), vascular cell adhesion molecule 1 (VCAM-1), and E-selectin expression in HUVECs, which led to promotion of monocyte adhesion to HUVECs. Treatment with SFN, BITC, and PEITC (0–10 μM) dose-dependently induced heme oxygenase (HO)-1, glutamate cysteine ligase (GCL) catalytic and modifier subunit expression, intracellular glutathione content, and antioxidant response element (ARE)-luciferase reporter activity. SFN, BITC, and PEITC pretreatment reversed oxLDL-induced ROS production, NFκB nuclear translocation, κB-reporter activity, ICAM-1, VCAM-1, and E-selectin expression, and monocyte adhesion to endothelial cells. Both heme oxygenase 1 (HO-1) and nuclear factor erythroid 2-related factor 2 (Nrf2) knockdown attenuated the isothiocyanate inhibition of oxLDL-induced ROS production, κB-reporter activity, and adhesion molecule expression. Conclusion SFN, BITC, and PEITC protect against oxLDL-induced endothelial damage by upregulating Nrf2-dependent HO-1 and GCL expression, which leads to inhibition of NFκB activation and ICAM-1, VCAM-1, and E-selectin expression." @default.
- W2019033423 created "2016-06-24" @default.
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- W2019033423 date "2013-07-09" @default.
- W2019033423 modified "2023-09-30" @default.
- W2019033423 title "Isothiocyanates protect against oxidized LDL-induced endothelial dysfunction by upregulating Nrf2-dependent antioxidation and suppressing NFκB activation" @default.
- W2019033423 cites W1508323668 @default.
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- W2019033423 cites W1983321171 @default.
- W2019033423 cites W1984686339 @default.
- W2019033423 cites W1986841539 @default.
- W2019033423 cites W1994944002 @default.
- W2019033423 cites W1997007516 @default.
- W2019033423 cites W2000495014 @default.
- W2019033423 cites W2004079184 @default.
- W2019033423 cites W2009533247 @default.
- W2019033423 cites W2021746563 @default.
- W2019033423 cites W2036603447 @default.
- W2019033423 cites W2039930671 @default.
- W2019033423 cites W2048168782 @default.
- W2019033423 cites W2048246530 @default.
- W2019033423 cites W2055448873 @default.
- W2019033423 cites W2056034929 @default.
- W2019033423 cites W2056674840 @default.
- W2019033423 cites W2077762036 @default.
- W2019033423 cites W2086247955 @default.
- W2019033423 cites W2087551745 @default.
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- W2019033423 cites W2146612164 @default.
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- W2019033423 doi "https://doi.org/10.1002/mnfr.201300063" @default.
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