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- W2019034135 abstract "We investigated the cognition enhancing effects of ginsenoside Rb1 and Rg1. Mice were trained in a Morris water maze following injection (i.p.) of Rb1 (1 mg/kg) or Rg1 (1 mg/kg) for 4 days. Both Rb1- and Rg1-injected mice showed enhanced spatial learning compared to control animals. The hippocampus, but not the frontal cortex, of treated mice contained higher density of a synaptic marker protein, synaptophysin, compared to control mice. Electrophysiological recordings in hippocampal slices revealed that Rb1 or Rg1 injection did not change the magnitude of paired-pulse facilitation or long-term potentiation. Our results suggest that Rb1 and Rg1 enhance spatial learning ability by increasing hippocampal synaptic density without changing plasticity of individual synapses." @default.
- W2019034135 created "2016-06-24" @default.
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- W2019034135 date "2001-01-01" @default.
- W2019034135 modified "2023-10-17" @default.
- W2019034135 title "Ginsenoside Rb1 and Rg1 improve spatial learning and increase hippocampal synaptophysin level in mice" @default.
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- W2019034135 doi "https://doi.org/10.1002/jnr.1045" @default.
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