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• W2019041567 abstract "Matrix metalloproteinase 9 (MMP9) plays an important role in the pathogenesis of multiple sclerosis (MS). However, the impact of genetic variants affecting MMP9 on MS susceptibility is still in debate. We could not detect an association of MMP9 SNPs with MS on a genome-wide significance level by SNP genotyping, followed by imputation of SNPs within a region stretching 2Mbp up- and down-stream of MMP9. Rs6073751, located within WFDC2, was found associated with MS most strongly. Rs3918242, associated with MS according to previous reports, showed nominal significance only. Meta-analysis of our own and published data did not confirm this effect." @default.
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• W2019041567 date "2015-02-01" @default.
• W2019041567 modified "2023-10-18" @default.
• W2019041567 title "MS susceptibility is not affected by single nucleotide polymorphisms in the MMP9 gene" @default.
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• W2019041567 doi "https://doi.org/10.1016/j.jneuroim.2015.01.008" @default.
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