FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2019043248> ?p ?o ?g. }

• W2019043248 endingPage "8639" @default.
• W2019043248 startingPage "8629" @default.
• W2019043248 abstract "δ Subunit-containing GABA A receptors are located predominantly at nonsynaptic sites in the dentate gyrus where they may play important roles in controlling neuronal excitability through tonic inhibition and responses to GABA spillover. Immunohistochemical methods were used to determine whether δ subunit expression was altered after pilocarpine-induced status epilepticus in C57BL/6 mice in ways that could increase excitability of the dentate gyrus. In pilocarpine-treated animals, the normal diffuse labeling of the δ subunit in the dentate molecular layer was decreased by 4 d after status epilepticus (latent period) and remained low throughout the period of chronic seizures. In contrast, diffuse labeling of α4 and γ2 subunits, potentially interrelated GABA A receptor subunits, was increased during the chronic period. Interestingly, δ subunit labeling of many interneurons progressively increased after pilocarpine treatment. Consistent with the observed changes in δ subunit labeling, physiological studies revealed increased excitability in the dentate gyrus of slices obtained from the pilocarpine-treated mice and demonstrated that physiological concentrations of the neurosteroid tetrahydrodeoxycorticosterone were less effective in reducing excitability in the pilocarpine-treated animals than in controls. The findings support the idea that alterations in nonsynaptic δ subunit-containing GABA A receptors in both principal cells and interneurons could contribute to increased seizure susceptibility in the hippocampal formation in a temporal lobe epilepsy model." @default.
• W2019043248 created "2016-06-24" @default.
• W2019043248 creator A5003372884 @default.
• W2019043248 creator A5011957042 @default.
• W2019043248 creator A5017700541 @default.
• W2019043248 creator A5057347749 @default.
• W2019043248 creator A5061089065 @default.
• W2019043248 date "2004-09-29" @default.
• W2019043248 modified "2023-10-17" @default.
• W2019043248 title "Altered Expression of the δ Subunit of the GABA_AReceptor in a Mouse Model of Temporal Lobe Epilepsy" @default.
• W2019043248 cites W1480770914 @default.
• W2019043248 cites W1533140355 @default.
• W2019043248 cites W1548516628 @default.
• W2019043248 cites W1550227666 @default.
• W2019043248 cites W1565381549 @default.
• W2019043248 cites W1607092694 @default.
• W2019043248 cites W1684501056 @default.
• W2019043248 cites W1921693572 @default.
• W2019043248 cites W1967380120 @default.
• W2019043248 cites W1974016987 @default.
• W2019043248 cites W1977052342 @default.
• W2019043248 cites W1980021607 @default.
• W2019043248 cites W1982890379 @default.
• W2019043248 cites W1989530188 @default.
• W2019043248 cites W2007778040 @default.
• W2019043248 cites W2009246103 @default.
• W2019043248 cites W2015236121 @default.
• W2019043248 cites W2021194790 @default.
• W2019043248 cites W2021952055 @default.
• W2019043248 cites W2022549781 @default.
• W2019043248 cites W2023132644 @default.
• W2019043248 cites W2023871512 @default.
• W2019043248 cites W2032093027 @default.
• W2019043248 cites W2035181705 @default.
• W2019043248 cites W2036939803 @default.
• W2019043248 cites W2039738625 @default.
• W2019043248 cites W2047243202 @default.
• W2019043248 cites W2049521887 @default.
• W2019043248 cites W2060589548 @default.
• W2019043248 cites W2061947653 @default.
• W2019043248 cites W2066902435 @default.
• W2019043248 cites W2072962057 @default.
• W2019043248 cites W2085556169 @default.
• W2019043248 cites W2088143216 @default.
• W2019043248 cites W2088296164 @default.
• W2019043248 cites W2091060078 @default.
• W2019043248 cites W2103946141 @default.
• W2019043248 cites W2104685361 @default.
• W2019043248 cites W2105418849 @default.
• W2019043248 cites W2109271430 @default.
• W2019043248 cites W2112425516 @default.
• W2019043248 cites W2119677026 @default.
• W2019043248 cites W2126962049 @default.
• W2019043248 cites W2136807926 @default.
• W2019043248 cites W2138788537 @default.
• W2019043248 cites W2139230578 @default.
• W2019043248 cites W2140256470 @default.
• W2019043248 cites W2143086898 @default.
• W2019043248 cites W2148169002 @default.
• W2019043248 cites W2154826398 @default.
• W2019043248 cites W2163363675 @default.
• W2019043248 cites W2170568072 @default.
• W2019043248 cites W2409013290 @default.
• W2019043248 cites W4293254491 @default.
• W2019043248 cites W4317524510 @default.
• W2019043248 doi "https://doi.org/10.1523/jneurosci.2877-04.2004" @default.
• W2019043248 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6729896" @default.
• W2019043248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15456836" @default.
• W2019043248 hasPublicationYear "2004" @default.
• W2019043248 type Work @default.
• W2019043248 sameAs 2019043248 @default.
• W2019043248 citedByCount "292" @default.
• W2019043248 countsByYear W20190432482012 @default.
• W2019043248 countsByYear W20190432482013 @default.
• W2019043248 countsByYear W20190432482014 @default.
• W2019043248 countsByYear W20190432482015 @default.
• W2019043248 countsByYear W20190432482016 @default.
• W2019043248 countsByYear W20190432482017 @default.
• W2019043248 countsByYear W20190432482018 @default.
• W2019043248 countsByYear W20190432482019 @default.
• W2019043248 countsByYear W20190432482020 @default.
• W2019043248 countsByYear W20190432482021 @default.
• W2019043248 countsByYear W20190432482022 @default.
• W2019043248 countsByYear W20190432482023 @default.
• W2019043248 crossrefType "journal-article" @default.
• W2019043248 hasAuthorship W2019043248A5003372884 @default.
• W2019043248 hasAuthorship W2019043248A5011957042 @default.
• W2019043248 hasAuthorship W2019043248A5017700541 @default.
• W2019043248 hasAuthorship W2019043248A5057347749 @default.
• W2019043248 hasAuthorship W2019043248A5061089065 @default.
• W2019043248 hasBestOaLocation W20190432481 @default.
• W2019043248 hasConcept C104292427 @default.
• W2019043248 hasConcept C104317684 @default.
• W2019043248 hasConcept C126322002 @default.
• W2019043248 hasConcept C134018914 @default.
• W2019043248 hasConcept C148762608 @default.
• W2019043248 hasConcept C168258287 @default.
• W2019043248 hasConcept C169760540 @default.

• next